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FältnamnIndikatorerMetadata
00006712naa a2200805 4500
001oai:lup.lub.lu.se:8dad66d1-99ab-44dc-8ec8-f3dc96a4470f
003SwePub
008190222s2019 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-162023
0247 a https://lup.lub.lu.se/record/8dad66d1-99ab-44dc-8ec8-f3dc96a4470f2 URI
0247 a https://doi.org/10.1016/j.parkreldis.2019.01.0192 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1620232 URI
040 a (SwePub)lud (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Riso, Lukasu German Cancer Research Centre4 aut
2451 0a General and abdominal adiposity and the risk of Parkinson's disease : A prospective cohort study
264 1b Elsevier BV,c 2019
520 a Introduction: Due to demographic change, an increase in the frequency of Parkinson's disease (PD) patients is expected in the future and, thus, the identification of modifiable risk factors is urgently needed. We aimed to examine the associations of body mass index (BMI) and waist circumference (WC) with incident PD. Methods: In 13 of the 23 centers of the European Prospective Investigation into Cancer and Nutrition (EPIC) study, a total of 734 incident cases of PD were identified between 1992 and 2012 with a mean follow-up of 12 years. Cox proportional hazards regression was used to calculate hazard ratios (HR) with 95% confidence intervals (CI). We modelled anthropometric variables as continuous and categorical exposures and performed subgroup analyses by potential effect modifiers including sex and smoking. Results: We found no association between BMI, WC and incident PD, neither among men nor among women. Among never and former smokers, BMI and waist circumference were also not associated with PD risk. For male smokers, however, we observed a statistically significant inverse association between BMI and PD risk (HR 0.51, 95%CI: 0.30, 0.84) and the opposite for women, i.e. a significant direct association of BMI (HR 1.79, 95%CI: 1.04, 3.08) and waist circumference (HR 1.64, 95%CI: 1.03, 2.61) with risk of PD. Conclusion: Our data revealed no association between excess weight and PD risk but a possible interaction between anthropometry, sex and smoking.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Allmänmedicin0 (SwePub)302242 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex General Practice0 (SwePub)302242 hsv//eng
653 a BMI
653 a Cohort
653 a EPIC
653 a Overweight
653 a Parkinson
653 a Smoking
653 a Parkinson
7001 a Kaaks, Rudolfu German Cancer Research Centre4 aut
7001 a Kühn, Tilmanu German Cancer Research Centre4 aut
7001 a Sookthai, Disornu German Cancer Research Centre4 aut
7001 a Forsgren, Larsu Umeå universitet,Umeå University,Klinisk neurovetenskap,Enheten för biobanksforskning4 aut0 (Swepub:umu)lafo0001
7001 a Trupp, Milesu Umeå universitet,Umeå University,Klinisk neurovetenskap,Enheten för biobanksforskning4 aut0 (Swepub:umu)mitr0006
7001 a Trichopoulou, Antoniau Hellenic Health Foundation, Athens4 aut
7001 a La Vecchia, Carlou Hellenic Health Foundation, Athens,University of Milan4 aut
7001 a Karakatsani, Annau National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens4 aut
7001 a Gavrila, Dianau Murcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP)4 aut
7001 a Ferrari, Pietrou International Agency for Research on Cancer, World Health Organization4 aut
7001 a Freisling, Heinzu International Agency for Research on Cancer, World Health Organization4 aut
7001 a Petersson, Jesperu Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)neur-jpe
7001 a Lewan, Susanneu Lund University4 aut
7001 a Vermeulen, Roel CHu University Medical Center Utrecht,Utrecht University4 aut
7001 a Panico, Salvatoreu University of Naples Federico II4 aut
7001 a Masala, Giovannau Cancer Research and Prevention Institute (ISPO)4 aut
7001 a Ardanaz, Evau CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)4 aut0 (Swepub:lu)extLU-05
7001 a Krogh, Vittoriou Istituto Nazionale dei Tumori4 aut
7001 a Perneczky, Robert G.u Imperial College London,University Hospital Munich,German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut
7001 a Middleton, Lefkos T.u Imperial College London4 aut
7001 a Mokoroa, Olatzu Biodonostia Health Research Institute4 aut
7001 a Sacerdote, Carlottau Citta' della Salute e della Scienza Hospital-University of Turin,Centre for Cancer Epidemiology and Prevention (CPO Piemonte)4 aut
7001 a Sieri, Sabrinau Istituto Nazionale dei Tumori4 aut
7001 a Hayat, Shabina A.u University of Cambridge4 aut
7001 a Brayne, Carolu University of Cambridge4 aut
7001 a Riboli, Eliou Imperial College London4 aut
7001 a Vineis, Paolou Imperial College London4 aut
7001 a Gallo, Valentinau Imperial College London,Queen Mary University4 aut
7001 a Katzke, Verena A.u German Cancer Research Centre4 aut
7102 a Umeå Universityb German Cancer Research Centre4 org
7730 t Parkinsonism and Related Disordersd : Elsevier BVg 62, s. 98-104q 62<98-104x 1353-8020x 1873-5126
8564 u http://dx.doi.org/10.1016/j.parkreldis.2019.01.019y FULLTEXT
8564 u https://qmro.qmul.ac.uk/xmlui/bitstream/123456789/55363/6/Gallo_GENERAL%20AND%20ABDOMINAL%20ADIPOSITY_accepted%20manuscript_2019.pdf
8564 8u https://lup.lub.lu.se/record/8dad66d1-99ab-44dc-8ec8-f3dc96a4470f
8564 8u https://doi.org/10.1016/j.parkreldis.2019.01.019
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-162023

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