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Sökning: WFRF:(Vivar Nancy) > Constraints for mon...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003488naa a2200457 4500
001oai:DiVA.org:uu-421686
003SwePub
008201012s2012 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:124082057
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4216862 URI
0247 a https://doi.org/10.1002/eji.2011419242 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1240820572 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Fekete, Tünde4 aut
2451 0a Constraints for monocyte-derived dendritic cell functions under inflammatory conditions.
264 c 2011-12-14
264 1b Wiley,c 2012
338 a print2 rdacarrier
520 a The activation of TLRs expressed by macrophages or DCs, in the long run, leads to persistently impaired functionality. TLR signals activate a wide range of negative feedback mechanisms; it is not known, however, which of these can lead to long-lasting tolerance for further stimulatory signals. In addition, it is not yet understood how the functionality of monocyte-derived DCs (MoDCs) is influenced in inflamed tissues by the continuous presence of stimulatory signals during their differentiation. Here we studied the role of a wide range of DC-inhibitory mechanisms in a simple and robust model of MoDC inactivation induced by early TLR signals during differentiation. We show that the activation-induced suppressor of cytokine signaling 1 (SOCS1), IL-10, STAT3, miR146a and CD150 (SLAM) molecules possessed short-term inhibitory effects on cytokine production but did not induce persistent DC inactivation. On the contrary, the LPS-induced IRAK-1 downregulation could alone lead to persistent MoDC inactivation. Studying cellular functions in line with the activation-induced negative feedback mechanisms, we show that early activation of developing MoDCs allowed only a transient cytokine production that was followed by the downregulation of effector functions and the preservation of a tissue-resident non-migratory phenotype.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
7001 a Szabo, Attila4 aut
7001 a Beltrame, Luca4 aut
7001 a Vivar, Nancy4 aut
7001 a Pivarcsi, Andoru Karolinska Institutet4 aut0 (Swepub:uu)andpi932
7001 a Lanyi, Arpad4 aut
7001 a Cavalieri, Duccio4 aut
7001 a Rajnavölgyi, Eva4 aut
7001 a Rethi, Benceu Karolinska Institutet4 aut
7102 a Karolinska Institutet4 org
7730 t European Journal of Immunologyd : Wileyg 42:2, s. 458-69q 42:2<458-69x 0014-2980x 1521-4141
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.201141924
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421686
8564 8u https://doi.org/10.1002/eji.201141924
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:124082057

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