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DNA methylation met...
DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia
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Hannon, Eilis (author)
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Dempster, Emma L. (author)
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Mansell, Georgina (author)
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Burrage, Joe (author)
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Bass, Nick (author)
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Bohlken, Marc M. (author)
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Corvin, Aiden (author)
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Curtis, Charles J. (author)
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Dempster, David (author)
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Di Forti, Marta (author)
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Dinan, Timothy G. (author)
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Donohoe, Gary (author)
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Gaughran, Fiona (author)
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Gill, Michael (author)
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Gillespie, Amy (author)
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Gunasinghe, Cerisse (author)
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Hulshoff, Hilleke E. (author)
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Hultman, Christina M. (author)
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- Johansson, Viktoria (author)
- Karolinska Institutet
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Kahn, René S. (author)
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Kaprio, Jaakko (author)
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Kenis, Gunter (author)
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- Kowalec, Kaarina (author)
- Karolinska Institutet
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MacCabe, James (author)
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McDonald, Colm (author)
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McQuillin, Andrew (author)
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Morris, Derek W. (author)
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Murphy, Kieran C. (author)
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Mustard, Colette J. (author)
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Nenadic, Igor (author)
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O'Donovan, Michael C. (author)
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Quattrone, Diego (author)
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Richards, Alexander L. (author)
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Rutten, Bart P.F. (author)
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St Clair, David (author)
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Therman, Sebastian (author)
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Toulopoulou, Timothea (author)
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Van Os, Jim (author)
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Waddington, John L. (author)
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- Sullivan, Patrick (author)
- Karolinska Institutet
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Vassos, Evangelos (author)
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Breen, Gerome (author)
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Collier, David Andrew (author)
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Murray, Robin M. (author)
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Schalkwyk, Leonard S. (author)
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Mill, Jonathan (author)
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(creator_code:org_t)
- eLife Sciences Publications, 2021
- 2021
- English.
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In: eLIFE. - : eLife Sciences Publications. - 2050-084X. ; 10
- Related links:
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https://doi.org/10.7...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.7...
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http://kipublication...
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Abstract
Subject headings
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- We performed a systematic analysis of blood DNA methylation profiles from 4483 participants from seven independent cohorts identifying differentially methylated positions (DMPs) associated with psychosis, schizophrenia, and treatment-resistant schizophrenia. Psychosis cases were characterized by significant differences in measures of blood cell proportions and elevated smoking exposure derived from the DNA methylation data, with the largest differences seen in treatment-resistant schizophrenia patients. We implemented a stringent pipeline to meta-analyze epigenome-wide association study (EWAS) results across datasets, identifying 95 DMPs associated with psychosis and 1048 DMPs associated with schizophrenia, with evidence of colocalization to regions nominated by genetic association studies of disease. Many schizophrenia-associated DNA methylation differences were only present in patients with treatment-resistant schizophrenia, potentially reflecting exposure to the atypical antipsychotic clozapine. Our results highlight how DNA methylation data can be leveraged to identify physiological (e.g., differential cell counts) and environmental (e.g., smoking) factors associated with psychosis and molecular biomarkers of treatment-resistant schizophrenia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- DNA methylation
- clozapine
- epigenetics
- genetics
- genomics
- human
- psychosis
- schizophrenia
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hannon, Eilis
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Dempster, Emma L ...
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Mansell, Georgin ...
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Burrage, Joe
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Bass, Nick
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Bohlken, Marc M.
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show more...
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Corvin, Aiden
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Curtis, Charles ...
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Dempster, David
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Di Forti, Marta
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Dinan, Timothy G ...
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Donohoe, Gary
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Gaughran, Fiona
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Gill, Michael
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Gillespie, Amy
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Gunasinghe, Ceri ...
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Hulshoff, Hillek ...
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Hultman, Christi ...
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Johansson, Vikto ...
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Kahn, René S.
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Kaprio, Jaakko
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Kenis, Gunter
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Kowalec, Kaarina
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MacCabe, James
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McDonald, Colm
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McQuillin, Andre ...
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Morris, Derek W.
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Murphy, Kieran C ...
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Mustard, Colette ...
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Nenadic, Igor
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O'Donovan, Micha ...
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Quattrone, Diego
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Richards, Alexan ...
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Rutten, Bart P.F ...
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St Clair, David
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Therman, Sebasti ...
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Toulopoulou, Tim ...
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Van Os, Jim
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Waddington, John ...
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Sullivan, Patric ...
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Vassos, Evangelo ...
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Breen, Gerome
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Collier, David A ...
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Murray, Robin M.
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Schalkwyk, Leona ...
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Mill, Jonathan
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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eLIFE
- By the university
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Umeå University
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Karolinska Institutet