Progression of white matter hyperintensities and incidence of new lacunes over a 3-year period: the Leukoaraiosis and Disability study.

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Fältnamn	Indikatorer	Metadata
000		05347naa a2201033 4500
001		oai:gup.ub.gu.se/98800
003		SwePub
008		240528s2008 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:116999472
024	7	a https://gup.ub.gu.se/publication/988002 URI
024	7	a https://doi.org/10.1161/STROKEAHA.107.4985352 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1169994722 URI
040		a (SwePub)gud (SwePub)ki
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Gouw, Alida A4 aut
245	1 0	a Progression of white matter hyperintensities and incidence of new lacunes over a 3-year period: the Leukoaraiosis and Disability study.
264	1	c 2008
520		a BACKGROUND AND PURPOSE: We studied the natural course of white matter hyperintensities (WMH) and lacunes, the main MRI representatives of small vessel disease, over time and evaluated possible predictors for their development. METHODS: Baseline and repeat MRI (3-year follow-up) were collected within the multicenter, multinational Leukoaraiosis and Disability study (n=396). Baseline WMH were scored on MRI by the Fazekas scale and the Scheltens scale. WMH progression was assessed using the modified Rotterdam Progression scale (absence/presence of progression in 9 brain regions). Baseline and new lacunes were counted per region. WMH and lacunes at baseline and vascular risk factors were evaluated as predictors of WMH progression and new lacunes. RESULTS: WMH progressed (mean+/-SD=1.9+/-1.8) mostly in the subcortical white matter, where WMH was also most prevalent at baseline. The majority of new lacunes, which were found in 19% of the subjects (maximum=9), also appeared in the subcortical white matter, mainly of the frontal lobes, whereas most baseline lacunes were located in the basal ganglia. Baseline WMH and lacunes predicted both WMH progression and new lacunes. Furthermore, previous stroke, diabetes, and blood glucose were risk factors for WMH progression. Male sex, hypertension, systolic blood pressure, previous stroke, body mass index, high-density lipoprotein, and triglyceride levels were risk factors for new lacunes. CONCLUSIONS: WMH and lacunes progressed over time, predominantly in the subcortical white matter. Progression was observed especially in subjects with considerable WMH and lacunes at baseline. Moreover, the presence of vascular risk factors at baseline predicted WMH progression and new lacunes over a 3-year period.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
653		a Aged
653		a Aged
653		a 80 and over
653		a Basal Ganglia
653		a blood supply
653		a pathology
653		a physiopathology
653		a Brain
653		a blood supply
653		a pathology
653		a physiopathology
653		a Brain Infarction
653		a epidemiology
653		a pathology
653		a physiopathology
653		a Brain Ischemia
653		a epidemiology
653		a pathology
653		a physiopathology
653		a Cardiovascular Diseases
653		a epidemiology
653		a Cerebral Arteries
653		a pathology
653		a physiopathology
653		a Comorbidity
653		a Disease Progression
653		a Female
653		a Follow-Up Studies
653		a Frontal Lobe
653		a blood supply
653		a pathology
653		a physiopathology
653		a Humans
653		a Hyperlipidemias
653		a epidemiology
653		a Incidence
653		a Leukoaraiosis
653		a epidemiology
653		a pathology
653		a physiopathology
653		a Magnetic Resonance Imaging
653		a Male
653		a Nerve Fibers
653		a Myelinated
653		a pathology
653		a Prevalence
653		a Risk Factors
653		a Time Factors
700	1	a van der Flier, Wiesje M4 aut
700	1	a Fazekas, Franz4 aut
700	1	a van Straaten, Elisabeth C W4 aut
700	1	a Pantoni, Leonardo4 aut
700	1	a Poggesi, Anna4 aut
700	1	a Inzitari, Domenico4 aut
700	1	a Erkinjuntti, Timo4 aut
700	1	a Wahlund, Lars Ou Karolinska Institutet4 aut
700	1	a Waldemar, Gunhild4 aut
700	1	a Schmidt, Reinhold4 aut
700	1	a Scheltens, Philip4 aut
700	1	a Barkhof, Frederik4 aut
700	1	a Wallin, Anders,d 1950u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xwaand
710	2	a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org
773	0	t Stroke; a journal of cerebral circulationg 39:5, s. 1414-20q 39:5<1414-20x 1524-4628
856	4 8	u https://gup.ub.gu.se/publication/98800
856	4 8	u https://doi.org/10.1161/STROKEAHA.107.498535
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:116999472

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