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High rate and large intercentre variability in retreatment of retinopathy of prematurity in infants born < 24 gestational weeks

Lundgren, Pia (författare)
Gothenburg University,Göteborgs universitet,Örebro University,The Sahlgrenska Centre for Pediatric Ophthalmology Research, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Clin Neurosci,Sahlgrenska Ctr Pediat Ophthal, Gothenburg, Sweden.;Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
Jacobson, Lena (författare)
Karolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.,Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
Hård, Anna-Lena (författare)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,The Sahlgrenska Centre for Pediatric Ophthalmology Research, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Al-Hawasi, Abbas (författare)
Linköping University,Linköpings universitet,Avdelningen för sinnesorgan och kommunikation,Medicinska fakulteten,Linköping Univ, Dept Clin & Expt Med, Linköping, Sweden.,Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
Larsson, Eva, 1961- (författare)
Uppsala universitet,Uppsala University,Harvard Medical School,Uppsala Univ, Sweden,Söderberg: Oftalmiatrik,Institution of Neuroscience/Ophthalmology, Uppsala University, Uppsala, Sweden
Gränse, Lotta (författare)
Lund University,Lunds universitet,Oftalmologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Ophthalmology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Skane Univ Hosp, Ophthalmol, Dept Clin Sci, Lund, Sweden.,Department of Clinical Sciences, Ophthalmology, Skåne University Hospital, Lund University, Lund, Sweden
Saric, Marie (författare)
Umeå universitet,Umeå University,Umeå Univ, Dept Clin Sci, Ophthalmol, Umeå, Sweden.,Oftalmiatrik
Sunnqvist, Birgitta (författare)
Lanssjukhuset Ryhov, Dept Ophthalmol, Jönköping, Sweden.,Ryhov County Hospital, Jönköping,Department of Ophthalmology, Länssjukhuset Ryhov, Jonkoping, Sweden
Tornqvist, Kristina (författare)
Lund University,Lunds universitet,Oftalmologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Ophthalmology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Skane Univ Hosp, Ophthalmol, Dept Clin Sci, Lund, Sweden.,Department of Clinical Sciences, Ophthalmology, Skåne University Hospital, Lund University, Lund, Sweden
Wallin, Agneta (författare)
St Erik Eye Hosp, Stockholm, Sweden.,St Erik Eye Hospital, Stockholm, Sweden
Holmström, Gerd, 1951- (författare)
Uppsala universitet,Uppsala University,Uppsala Univ, Sweden,Söderberg: Oftalmiatrik,Institution of Neuroscience/Ophthalmology, Uppsala University, Uppsala, Sweden
Le Smith, Lois (författare)
Harvard Med Sch, Boston Childrens Hosp, Dept Ophthalmol, Boston, MA 02115 USA.,Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, MA, Boston, United States
Morsing, Eva (författare)
Skane Univ Hosp Lund, Clin Sci Lund, Dept Pediat, Lund, Sweden.,Department of Pediatrics, Clinical Sciences Lund, Skåne University Hospital Lund, Lund, Sweden
Hellström, Ann (författare)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,The Sahlgrenska Centre for Pediatric Ophthalmology Research, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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 (creator_code:org_t)
2021-04-21
2021
Engelska.
Ingår i: BMJ Open Ophthalmology. - : BMJ Publishing Group Ltd. - 2397-3269. ; 6:1
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Objective Prematurity is a major risk factor for retinopathy of prematurity (ROP). We aimed to elucidate ROP prevalence, treatment and retreatment in infants born before 24 gestational age (GA) weeks in a Swedish cohort. Methods and analysis Infants with completed ROP screening, born at <24 GA weeks, 2007-2018 in Sweden were included. Data of GA, birth weight (BW), sex, neonatal morbidities, maximal ROP stage, aggressive posterior ROP (APROP), ROP treatments, treatment modality and treatment centre were retrieved. Results In total, 399 infants, with a mean GA of 23.2 weeks (range 21.9-23.9) and a mean BW of 567 g (range 340-874), were included. ROP was detected in 365 (91.5%) infants, 173 (43.4%) were treated for ROP and 68 of 173 (39.3%) were treated more than once. As the first treatment, 142 (82.0%) received laser and 29 (16.1%) received intravitreal injection of antivascular endothelial growth factor (anti-VEGF). Retreatment was performed after first laser in 46 of 142 (32.4%) and in 20 of 29 (69.0%) after first anti-VEGF treatment. Retreatment rate was not associated with GA, BW or sex but with APROP, treatment method (anti-VEGF) and treatment centre where the laser was performed (p<0.001). Twenty eyes progressed to retinal detachment, and two infants developed unilateral endophthalmitis after anti-VEGF treatment. Conclusion Infants, born at <24 weeks GA, had high rates of treatment-warranting ROP and retreatments. Treatment centre highly influenced the retreatment rate after laser indicating that laser treatment could be improved in some settings.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Pediatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Pediatrics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Oftalmologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Ophthalmology (hsv//eng)

Nyckelord

retina
retina
Ophthalmology

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