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The association bet...
The association between familial risk and brain abnormalities is disease specific : an ENIGMA-relatives study of schizophrenia and bipolar disorder
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de Zwarte, Sonja M. C. (author)
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Brouwer, Rachel M. (author)
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- Agartz, Ingrid (author)
- Karolinska Institutet
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show more...
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Alda, Martin (author)
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Aleman, André (author)
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Alpert, Kathryn I. (author)
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Bearden, Carrie E. (author)
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Bertolino, Alessandro (author)
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Bois, Catherine (author)
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Bonvino, Aurora (author)
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Bramon, Elvira (author)
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Buimer, Elizabeth E. L. (author)
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Cahn, Wiepke (author)
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Cannon, Dara M. (author)
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Cannon, Tyrone D. (author)
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Caseras, Xavier (author)
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Castro-Fornieles, Josefina (author)
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Chen, Qiang (author)
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Chung, Yoonho (author)
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De la Serna, Elena (author)
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Di Giorgio, Annabella (author)
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Doucet, Gaelle E. (author)
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Eker, Mehmet Cagdas (author)
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Erk, Susanne (author)
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Fears, Scott C. (author)
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Foley, Sonya F. (author)
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Frangou, Sophia (author)
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Frankland, Andrew (author)
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Fullerton, Janice M. (author)
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Glahn, David C. (author)
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Goghari, Vina M. (author)
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Goldman, Aaron L. (author)
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Gonul, Ali Saffet (author)
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Gruber, Oliver (author)
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de Haan, Lieuwe (author)
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Hajek, Tomas (author)
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Hawkins, Emma L. (author)
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Heinz, Andreas (author)
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Hillegers, Manon H. J. (author)
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Hulshoff Pol, Hilleke E. (author)
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Hultman, Christina M. (author)
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- Ingvar, Martin (author)
- Karolinska Institutet
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- Johansson, Viktoria (author)
- Karolinska Institutet
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- Jönsson, Erik G. (author)
- Karolinska Institutet
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Kane, Fergus (author)
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Kempton, Matthew J. (author)
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Koenis, Marinka M. G. (author)
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Kopecek, Miloslav (author)
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Krabbendam, Lydia (author)
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Krämer, Bernd (author)
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Lawrie, Stephen M. (author)
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Lenroot, Rhoshel K. (author)
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Marcelis, Machteld (author)
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Marsman, Jan-Bernard C. (author)
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Mattay, Venkata S. (author)
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McDonald, Colm (author)
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Meyer-Lindenberg, Andreas (author)
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Michielse, Stijn (author)
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Mitchell, Philip B. (author)
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Moreno, Dolores (author)
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Murray, Robin M. (author)
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Mwangi, Benson (author)
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Najt, Pablo (author)
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Neilson, Emma (author)
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Newport, Jason (author)
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van Os, Jim (author)
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Overs, Bronwyn (author)
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Ozerdem, Aysegul (author)
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Picchioni, Marco M. (author)
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Richter, Anja (author)
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Roberts, Gloria (author)
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Aydogan, Aybala Saricicek (author)
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Schofield, Peter R. (author)
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Simsek, Fatma (author)
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Soares, Jair C. (author)
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Sugranyes, Gisela (author)
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Toulopoulou, Timothea (author)
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Tronchin, Giulia (author)
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Walter, Henrik (author)
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Wang, Lei (author)
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Weinberger, Daniel R. (author)
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Whalley, Heather C. (author)
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Yalin, Nefize (author)
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Andreassen, Ole A. (author)
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Ching, Christopher R. K. (author)
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van Erp, Theo G. M. (author)
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Turner, Jessica A. (author)
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Jahanshad, Neda (author)
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Thompson, Paul M. (author)
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Kahn, René S. (author)
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van Haren, Neeltje E. M. (author)
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(creator_code:org_t)
- Elsevier, 2019
- 2019
- English.
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In: Biological Psychiatry. - : Elsevier. - 0006-3223 .- 1873-2402. ; 86:7, s. 545-556
- Related links:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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http://www.biologica...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- BACKGROUND: Schizophrenia and bipolar disorder share genetic liability, and some structural brain abnormalities are common to both conditions. First-degree relatives of patients with schizophrenia (FDRs-SZ) show similar brain abnormalities to patients, albeit with smaller effect sizes. Imaging findings in first-degree relatives of patients with bipolar disorder (FDRs-BD) have been inconsistent in the past, but recent studies report regionally greater volumes compared with control subjects.METHODS: We performed a meta-analysis of global and subcortical brain measures of 6008 individuals (1228 FDRs-SZ, 852 FDRs-BD, 2246 control subjects, 1016 patients with schizophrenia, 666 patients with bipolar disorder) from 34 schizophrenia and/or bipolar disorder family cohorts with standardized methods. Analyses were repeated with a correction for intracranial volume (ICV) and for the presence of any psychopathology in the relatives and control subjects.RESULTS: FDRs-BD had significantly larger ICV (d = +0.16, q < .05 corrected), whereas FDRs-SZ showed smaller thalamic volumes than control subjects (d = -0.12, q < .05 corrected). ICV explained the enlargements in the brain measures in FDRs-BD. In FDRs-SZ, after correction for ICV, total brain, cortical gray matter, cerebral white matter, cerebellar gray and white matter, and thalamus volumes were significantly smaller; the cortex was thinner (d < -0.09, q < .05 corrected); and third ventricle was larger (d = +0.15, q < .05 corrected). The findings were not explained by psychopathology in the relatives or control subjects.CONCLUSIONS: Despite shared genetic liability, FDRs-SZ and FDRs-BD show a differential pattern of structural brain abnormalities, specifically a divergent effect in ICV. This may imply that the neurodevelopmental trajectories leading to brain anomalies in schizophrenia or bipolar disorder are distinct.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Bipolar disorder
- Familial risk
- Imaging
- Meta-analysis
- Neurodevelopment
- Schizophrenia
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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de Zwarte, Sonja ...
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Brouwer, Rachel ...
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Agartz, Ingrid
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Alda, Martin
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Aleman, André
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Alpert, Kathryn ...
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show more...
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Bearden, Carrie ...
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Bertolino, Aless ...
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Bois, Catherine
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Bonvino, Aurora
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Bramon, Elvira
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Buimer, Elizabet ...
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Cahn, Wiepke
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Cannon, Dara M.
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Cannon, Tyrone D ...
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Caseras, Xavier
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Castro-Fornieles ...
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Chen, Qiang
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Chung, Yoonho
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De la Serna, Ele ...
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Di Giorgio, Anna ...
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Doucet, Gaelle E ...
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Eker, Mehmet Cag ...
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Erk, Susanne
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Fears, Scott C.
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Foley, Sonya F.
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Frangou, Sophia
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Frankland, Andre ...
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Fullerton, Janic ...
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Glahn, David C.
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Goghari, Vina M.
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Goldman, Aaron L ...
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Gonul, Ali Saffe ...
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Gruber, Oliver
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de Haan, Lieuwe
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Hajek, Tomas
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Hawkins, Emma L.
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Heinz, Andreas
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Hillegers, Manon ...
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Hulshoff Pol, Hi ...
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Hultman, Christi ...
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Ingvar, Martin
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Johansson, Vikto ...
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Jönsson, Erik G.
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Kane, Fergus
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Kempton, Matthew ...
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Koenis, Marinka ...
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Kopecek, Milosla ...
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Krabbendam, Lydi ...
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Krämer, Bernd
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Lawrie, Stephen ...
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Lenroot, Rhoshel ...
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Marcelis, Machte ...
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Marsman, Jan-Ber ...
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Mattay, Venkata ...
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McDonald, Colm
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Meyer-Lindenberg ...
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Michielse, Stijn
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Mitchell, Philip ...
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Moreno, Dolores
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Murray, Robin M.
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Mwangi, Benson
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Najt, Pablo
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Neilson, Emma
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Newport, Jason
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van Os, Jim
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Overs, Bronwyn
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Ozerdem, Aysegul
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Picchioni, Marco ...
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Richter, Anja
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Roberts, Gloria
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Aydogan, Aybala ...
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Schofield, Peter ...
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Simsek, Fatma
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Soares, Jair C.
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Sugranyes, Gisel ...
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Toulopoulou, Tim ...
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Tronchin, Giulia
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Walter, Henrik
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Wang, Lei
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Weinberger, Dani ...
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Whalley, Heather ...
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Yalin, Nefize
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Andreassen, Ole ...
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Ching, Christoph ...
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van Erp, Theo G. ...
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Turner, Jessica ...
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Jahanshad, Neda
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Thompson, Paul M ...
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Kahn, René S.
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van Haren, Neelt ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Biological Psych ...
- By the university
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Umeå University
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Karolinska Institutet