WFRF:(Weis S)
Sökning: WFRF:(Weis S) > (1995-1999) > Chromatin condensat...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02504naa a2200301 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:1944113 | |
| 003 | SwePub | |
| 008 | 240701s1996 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19441132 URI |
| 024 | 7 | a https://doi.org/10.1042/bj31807492 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Kass, GEN4 aut |
| 245 | 1 0 | a Chromatin condensation during apoptosis requires ATP |
| 264 | 1 | b Portland Press Ltd.c 1996 |
| 520 | a The processes leading to morphological changes of the chromatin in cells that undergo apoptosis are presently unclear. We have recently shown that chromatin fragmentation and the nuclear morphological changes typically seen in apoptosis were reproduced in an in vitro system comprised of isolated rat thymocyte nuclei incubated in the presence of a lysate from Fas/APO-1-stimulated JURKAT cells [Chow, Weis, Kass, Holmström, Eriksson and Orrenius (1995) FEBS Lett. 364, 134–138]. Using this in vitro system, we now report that the presence of ATP is necessary for chromatin condensation, its movement to the nuclear periphery and apoptotic body formation. In clear contrast, chromatin cleavage into high-molecular-mass and oligonucleosomal-length DNA fragments induced by lysates derived from Fas/APO-1-activated JURKAT cells did not require the presence of ATP. The induction of these morphological changes by ATP could not be substituted by the analogues, adenosine 5´-[β,γ-methylene]triphosphate and adenosine 5´-[α,β-methylene]-triphosphate, AMP, cAMP and UTP. However, adenosine 5´-[γ-thio]triphosphate, and to a lesser degree GTP and ADP, could partially replace ATP in inducing nuclear apoptotic morphological changes. It is concluded that ATP is essential for the morphological changes occurring in nuclei during apoptosis, but not for DNA fragmentation. | |
| 700 | 1 | a Eriksson, JE4 aut |
| 700 | 1 | a Weis, M4 aut |
| 700 | 1 | a Orrenius, Su Karolinska Institutet4 aut |
| 700 | 1 | a Chow, SC4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t The Biochemical journald : Portland Press Ltd.g 318318 ( Pt 3), s. 749-752q 318318 ( Pt 3)<749-752x 0264-6021x 1470-8728 |
| 856 | 4 | u https://europepmc.org/articles/pmc1217681?pdf=render |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1944113 |
| 856 | 4 8 | u https://doi.org/10.1042/bj3180749 |
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