WFRF:(Westphal O)
Sökning: WFRF:(Westphal O) > (1995-1999) > Improved final heig...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04713naa a2200577 4500 | |
| 001 | oai:DiVA.org:umu-45339 | |
| 003 | SwePub | |
| 008 | 110704s1996 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:113602991 | |
| 009 | oai:DiVA.org:uu-59554 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-453392 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1136029912 URI |
| 024 | 7 | a https://doi.org/10.1210/jcem.81.2.86362812 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-595542 URI |
| 040 | a (SwePub)umud (SwePub)kid (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Nilsson, K O4 aut |
| 245 | 1 0 | a Improved final height in girls with Turner's syndrome treated with growth hormone and oxandrolone. |
| 264 | 1 | b The Endocrine Society,c 1996 |
| 338 | a print2 rdacarrier | |
| 520 | a The spontaneous growth process in Turner's syndrome is characterized by a progressive decline in height velocity during childhood and no pubertal growth spurt. Therefore, therapy aimed at improving height during childhood as well as increasing final height is desirable for most girls with Turner's syndrome. Forty-five girls with Turner's syndrome, 9-16 yr of age (mean age, 12.2 yr), were allocated to three study groups. Group 1 (n = 13) was initially treated with oxandrolone alone; after 1 yr of treatment, GH without (group 1a; n = 6) or with (group 1b; n = 7) ethinyl estradiol was added. Group 2 (n = 17) was treated with GH plus oxandrolone. Group 3 (n = 15) was treated with GH, oxandrolone, and ethinyl estradiol. The dosage were: GH, 0.1 IU/kg.day; oxandrolone, 0.05 mg/kg.day; and ethinyl estradiol, 100 ng/kg.day. A height of 150 cm or more was achieved in 61%, 75%, and 60% of the girls in groups 1, 2, and 3, respectively. The most impressive increase in height was seen in group 2. In this group the mean final height was 154.2 cm (SD = 6.6), which is equivalent to a mean net gain of 8.5 cm (SD = 4.6) over the projected final height. In group 3, in which ethinyl estradiol was included from the start of therapy, the initially good height velocity decelerated after 1-2 yr of treatment. Their mean final height was 151.1 (SD = 4.6) cm, equivalent to a mean net gain of 3.0 cm (SD = 3.8). A similar growth-decelerating effect of ethinyl estradiol was seen in group 1b. We conclude that in girls with Turner's syndrome who are older than 9 yr of age, treatment with GH in combination with oxandrolone results in significant growth acceleration, imitating that in normal puberty, leading to a more favorable height during childhood. This mode of treatment also results in a significantly increased final height, permitting a great number of the girls to attain a final height of more than 150 cm. However, early addition of estrogen decelerates the height velocity and reduces the gain in height. | |
| 700 | 1 | a Albertsson-Wikland, K4 aut |
| 700 | 1 | a Alm, J4 aut |
| 700 | 1 | a Aronson, S4 aut |
| 700 | 1 | a Gustafsson, Ju Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/Tuvemo4 aut |
| 700 | 1 | a Hagenäs, Lu Karolinska Institutet4 aut |
| 700 | 1 | a Häger, A4 aut |
| 700 | 1 | a Ivarsson, S A4 aut |
| 700 | 1 | a Karlberg, J4 aut |
| 700 | 1 | a Kriström, Beritu Umeå universitet,Pediatrik4 aut0 (Swepub:umu)bekr0001 |
| 700 | 1 | a Marcus, Cu Karolinska Institutet4 aut |
| 700 | 1 | a Moell, C4 aut |
| 700 | 1 | a Ritzen, Mu Karolinska Institutet4 aut |
| 700 | 1 | a Tuvemo, Tu Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/Tuvemo4 aut |
| 700 | 1 | a Wattsgård, C4 aut |
| 700 | 1 | a Westgren, U4 aut |
| 700 | 1 | a Westphal, O4 aut |
| 700 | 1 | a Aman, Ju Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/Tuvemo4 aut |
| 700 | 1 | a AlbertssonWikland, K4 aut |
| 700 | 1 | a Ivarsson, SI4 aut |
| 710 | 2 | a Uppsala universitetb Institutionen för kvinnors och barns hälsa4 org |
| 773 | 0 | t Journal of Clinical Endocrinology and Metabolismd : The Endocrine Societyg 81, s. 635-q 81:2<635-40x 0021-972Xx 1945-7197 |
| 773 | 0 | t J Clin Endocrinol Metabold : The Endocrine Societyg 81, s. 635-q 81<635- |
| 856 | 4 | u https://academic.oup.com/jcem/article-pdf/81/2/635/10506833/jcem0635.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-45339 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:113602991 |
| 856 | 4 8 | u https://doi.org/10.1210/jcem.81.2.8636281 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-59554 |
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