Sökning: WFRF:(Wjst M) > (2015-2017) > The locus C11orf30 ...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 02795naa a2200421 4500 | |
001 | oai:DiVA.org:uu-245740 | |
003 | SwePub | |
008 | 150227s2015 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2457402 URI |
024 | 7 | a https://doi.org/10.1111/all.125572 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Amaral, A F S4 aut |
245 | 1 0 | a The locus C11orf30 increases susceptibility to poly-sensitization |
264 | c 2014-12-24 | |
264 | 1 | b Wiley,c 2015 |
338 | a print2 rdacarrier | |
520 | a A number of genetic variants have been associated with allergic sensitization, but whether these are allergen specific or increase susceptibility to poly-sensitization is unknown. Using data from the large multicentre population-based European Community Respiratory Health Survey, we assessed the association between 10 loci and specific IgE and skin prick tests to individual allergens and poly-sensitization. We found that the 10 loci associate with sensitization to different allergens in a nonspecific manner and that one in particular, C11orf30-rs2155219, doubles the risk of poly-sensitization (specific IgE/4 allergens: OR = 1.81, 95% CI 0.80-4.24; skin prick test/4+ allergens: OR = 2.27, 95% CI 1.34-3.95). The association of rs2155219 with higher levels of expression of C11orf30, which may be involved in transcription repression of interferon-stimulated genes, and its association with sensitization to multiple allergens suggest that this locus is highly relevant for atopy. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
700 | 1 | a Minelli, C4 aut |
700 | 1 | a Guerra, S4 aut |
700 | 1 | a Wjst, M4 aut |
700 | 1 | a Probst-Hensch, N4 aut |
700 | 1 | a Pin, I4 aut |
700 | 1 | a Svanes, C4 aut |
700 | 1 | a Janson, Christeru Uppsala universitet,Lungmedicin och allergologi4 aut0 (Swepub:uu)chrisjn |
700 | 1 | a Heinrich, J4 aut |
700 | 1 | a Jarvis, D L4 aut |
710 | 2 | a Uppsala universitetb Lungmedicin och allergologi4 org |
773 | 0 | t Allergy. European Journal of Allergy and Clinical Immunologyd : Wileyg 70:3, s. 328-333q 70:3<328-333x 0105-4538x 1398-9995 |
856 | 4 | u https://doi.org/10.1111/all.12557y Fulltext |
856 | 4 | u http://spiral.imperial.ac.uk/bitstream/10044/1/21574/6/Amaral_Allergy_revised_unmarked_forSPIRAL_11-3-2015.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-245740 |
856 | 4 8 | u https://doi.org/10.1111/all.12557 |
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