Research Priorities in Pediatric Asthma : Results of a Global Survey of Multiple Stakeholder Groups by the Pediatric Asthma in Real Life (PeARL) Think Tank

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Research Priorities in Pediatric Asthma : Results of a Global Survey of Multiple Stakeholder Groups by the Pediatric Asthma in Real Life (PeARL) Think Tank

Mathioudakis, Alexander G. (författare): University of Manchester,Wythenshawe Hospital

Custovic, Adnan (författare): Imperial College London

Deschildre, Antoine (författare): University of Lille,Lille University Hospital

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Ducharme, Francine M. (författare): University Of Quebec In Montreal

Kalayci, Omer (författare): Hacettepe University

Murray, Clare (författare): Wythenshawe Hospital,University of Manchester

Garcia, Antonio Nieto (författare): University and Polytechnic Hospital la Fe

Phipatanakul, Wanda (författare): Boston Children's Hospital

Price, David (författare): Observational and Pragmatic Research Institute Pte Ltd,University of Aberdeen

Sheikh, Aziz (författare): University of Edinburgh

Agache, Ioana (författare): Transylvania University Brasov

Bacharier, Leonard (författare): Washington University in St. Louis

Bonini, Matteo (författare): Catholic University of the Sacred Heart, Rome,Policlinico Universitario Agostino Gemelli,Imperial College London

Castro-Rodriguez, Jose A. (författare): Pontifical Catholic University of Chile

De Carlo, Giuseppe (författare): EFA European Federation of Allergy and Airways Diseases Patients' Associations

Craig, Timothy (författare): Pennsylvania State University

Diamant, Zuzana (författare): Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,University of Groningen,Thomayer Hospital,Charles University in Prague,University Medical Center Groningen

Feleszko, Wojciech (författare): Children's Hospital of Medical University of Warsaw

Ierodiakonou, Despo (författare): University of Crete

Gern, James E. (författare): University of Wisconsin-Madison

Grigg, Jonathan (författare): Queen Mary University

Hedlin, Gunilla (författare): Karolinska Institutet,Karolinska Institute

Hossny, Elham M. (författare): Children's Hospital of Ain Shams University

Jartti, Tuomas (författare): University of Turku,Turku University Hospital

Kaplan, Alan (författare): University of Toronto

Lemanske, Robert F. (författare): University of Wisconsin-Madison

Le Souef, Peter (författare): University of Western Australia, Crawley

Makela, Mika J. (författare): Skin and Allergy Hospital,University of Helsinki

Matricardi, Paolo M. (författare): Charité - University Medicine Berlin

Miligkos, Michael (författare): National and Kapodistrian University of Athens,Aghia Sophia Children's Hospital

Morais-Almeida, Mário (författare): Hospital CUF-Descobertas

Pite, Helena (författare): Hospital CUF-Descobertas,NOVA University Lisbon,CUF Infante Santo Hospital

Pitrez, Paulo M.C. (författare): Pontifical Catholic University of Rio Grande do Sul

Pohunek, Petr (författare): University Hospital Motol,Charles University in Prague

Roberts, Graham (författare): St Mary's Hospital, Newport,University of Southampton,University Hospital Southampton

Sanchez-Garcia, Sylvia (författare): Hospital Infantil Universitario Niño Jesús

Tsiligianni, Ioanna (författare): University of Crete

Turner, Steve (författare): University of Aberdeen,Royal Aberdeen Children's Hospital

Winders, Tonya A. (författare): Global Allergy and Asthma Platform (GAAPP),Allergy & Asthma Network

Wong, Gary (författare): Chinese University of Hong Kong

Xepapadaki, Paraskevi (författare): National and Kapodistrian University of Athens

Zar, Heather J. (författare): Red Cross War Memorial Children’s Hospital, Cape Town,University of Cape Town

Papadopoulos, Nikolaos G. (författare): University of Manchester,National and Kapodistrian University of Athens

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Elsevier BV, 2020
2020
Engelska.
Ingår i: Journal of Allergy and Clinical Immunology: In Practice. - : Elsevier BV. - 2213-2198 .- 2213-2201. ; 8:6, s. 9-1960

Relaterad länk:: http://dx.doi.org/10...; visa fler...; https://pure.rug.nl/...; https://lup.lub.lu.s...; https://doi.org/10.1...; http://kipublication...; visa färre...

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Background: Pediatric asthma remains a public health challenge with enormous impact worldwide. Objective: The aim of this study was to identify and prioritize unmet clinical needs in pediatric asthma, which could be used to guide future research and policy activities. Methods: We first identified unmet needs through an open-question survey administered to international experts in pediatric asthma who were members of the Pediatric Asthma in Real Life Think Tank. Prioritization of topics was then achieved through a second, extensive survey with global reach, of multiple stakeholders (leading experts, researchers, clinicians, patients, policy makers, and the pharmaceutical industry). Differences across responder groups were compared. Results: A total of 57 unmet clinical need topics identified by international experts were prioritized by 412 participants from 5 continents and 60 countries. Prevention of disease progression and prediction of future risk, including persistence into adulthood, emerged as the most urgent research questions. Stratified care, based on biomarkers, clinical phenotypes, the children's age, and demographics were also highly rated. The identification of minimum diagnostic criteria in different age groups, cultural perceptions of asthma, and best treatment by age group were priorities for responders from low-middle-income countries. There was good agreement across different stakeholder groups in all domains with some notable exceptions that highlight the importance of involving the whole range of stakeholders in formulation of recommendations. Conclusions: Different stakeholders agree in the majority of research and strategic (eg, prevention, personalized approach) priorities for pediatric asthma. Stakeholder diversity is crucial for highlighting divergent issues that future guidelines should consider.

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Av författaren/redakt...: Mathioudakis, Al ...; Custovic, Adnan; Deschildre, Anto ...; Ducharme, Franci ...; Kalayci, Omer; Murray, Clare; visa fler...; Garcia, Antonio ...; Phipatanakul, Wa ...; Price, David; Sheikh, Aziz; Agache, Ioana; Bacharier, Leona ...; Bonini, Matteo; Castro-Rodriguez ...; De Carlo, Giusep ...; Craig, Timothy; Diamant, Zuzana; Feleszko, Wojcie ...; Ierodiakonou, De ...; Gern, James E.; Grigg, Jonathan; Hedlin, Gunilla; Hossny, Elham M.; Jartti, Tuomas; Kaplan, Alan; Lemanske, Robert ...; Le Souef, Peter; Makela, Mika J.; Matricardi, Paol ...; Miligkos, Michae ...; Morais-Almeida, ...; Pite, Helena; Pitrez, Paulo M. ...; Pohunek, Petr; Roberts, Graham; Sanchez-Garcia, ...; Tsiligianni, Ioa ...; Turner, Steve; Winders, Tonya A ...; Wong, Gary; Xepapadaki, Para ...; Zar, Heather J.; Papadopoulos, Ni ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Lungmedicin och ...

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Av lärosätet: Lunds universitet; Karolinska Institutet

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Research Priorities in Pediatric Asthma : Results of a Global Survey of Multiple Stakeholder Groups by the Pediatric Asthma in Real Life (PeARL) Think Tank

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