Smoking, secondhand smoke, and cotinine levels in a subset of EPIC cohort

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Fältnamn	Indikatorer	Metadata
000		04663naa a2200829 4500
001		oai:DiVA.org:umu-45261
003		SwePub
008		110629s2011 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-452612 URI
024	7	a https://doi.org/10.1158/1055-9965.EPI-10-12352 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Baltar, Valéria Troncoso4 aut
245	1 0	a Smoking, secondhand smoke, and cotinine levels in a subset of EPIC cohort
264	1	b American Association for Cancer Research,c 2011
338		a print2 rdacarrier
520		a Background: Several countries are discussing new legislation regarding the ban on smoking in public places, based on the growing evidence of the hazards of secondhand smoke (SHS) exposure. The objective of the present study is to quantitatively assess the relationship between smoking, SHS, and serum cotinine levels in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: From a study on lung cancer in the EPIC cohort, questionnaire information on smoking was collected at enrolment, and cotinine was measured in serum. Three statistical models were applied by using samples available in a cross-section design: (i) cotinine levels by categories combining smoking and SHS (n = 859); (ii) the effect of hours of passive smoking exposure in nonsmokers only (n = 107); (iii) the effect of the number of cigarettes consumed per day in current smokers only (n = 832). All models were adjusted for country, sex, age, and body mass index. Results: Among nonsmokers, passive smokers presented significant differences in cotinine compared with nonexposed, with a marked (but not significant) difference among former-smokers. A one hour per day increment of SHS gave rise to a significant 2.58 nmol/L (0.45 ng/mL) increase in mean serum cotinine (P < 0.001). In current smokers, a one cigarette per day increment gave rise to a significant 22.44 nmol/L (3.95 ng/mL) increase in cotinine mean (P < 0.001). Conclusions: There is clear evidence that not only tobacco smoking but also involuntary exposure increases cotinine levels. Impact: This study strengthens the evidence for the benefits of a smoking ban in public places.
700	1	a Xun, Wei W4 aut
700	1	a Chuang, Shu-Chun4 aut
700	1	a Relton, Caroline4 aut
700	1	a Ueland, Per Magne4 aut
700	1	a Vollset, Stein Emil4 aut
700	1	a Midttun, Øivind4 aut
700	1	a Johansson, Mattias4 aut
700	1	a Slimani, Nadia4 aut
700	1	a Jenab, Mazda4 aut
700	1	a Clavel-Chapelon, Françoise4 aut
700	1	a Boutron-Ruault, Marie-Christine4 aut
700	1	a Fagherazzi, Guy4 aut
700	1	a Kaaks, Rudolf4 aut
700	1	a Rohrmann, Sabine4 aut
700	1	a Boeing, Heiner4 aut
700	1	a Weikert, Cornelia4 aut
700	1	a Bueno-de-Mesquita, H Bas4 aut
700	1	a Boshuizen, Hendriek C4 aut
700	1	a van Gils, Carla H4 aut
700	1	a Peeters, Petra H M4 aut
700	1	a Agudo, Antonio4 aut
700	1	a Barricarte, Aurelio4 aut
700	1	a Navarro, Carmen4 aut
700	1	a Rodríguez, Laudina4 aut
700	1	a Castaño, José Maria Huerta4 aut
700	1	a Larrañaga, Nerea4 aut
700	1	a Pérez, Maria José Sánchez4 aut
700	1	a Khaw, Kay-Tee4 aut
700	1	a Wareham, Nick4 aut
700	1	a Allen, Naomi E4 aut
700	1	a Crowe, Francesca4 aut
700	1	a Gallo, Valentina4 aut
700	1	a Norat, Teresa4 aut
700	1	a Tagliabue, Giovanna4 aut
700	1	a Masala, Giovanna4 aut
700	1	a Panico, Salvatore4 aut
700	1	a Sacerdote, Carlota4 aut
700	1	a Tumino, Rosario4 aut
700	1	a Trichopoulou, Antonia4 aut
700	1	a Lagiou, Pagona4 aut
700	1	a Bamia, Christina4 aut
700	1	a Rasmuson, Torgnyu Umeå universitet,Onkologi4 aut0 (Swepub:umu)tora0001
700	1	a Hallmans, Göranu Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001
700	1	a Roswall, Nina4 aut
700	1	a Tjønneland, Anne4 aut
700	1	a Riboli, Elio4 aut
700	1	a Brennan, Paul4 aut
700	1	a Vineis, Paolo4 aut
710	2	a Umeå universitetb Onkologi4 org
773	0	t Cancer Epidemiology, Biomarkers and Preventiond : American Association for Cancer Researchg 20:5, s. 869-875q 20:5<869-875x 1055-9965x 1538-7755
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-45261
856	4 8	u https://doi.org/10.1158/1055-9965.EPI-10-1235

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Av författaren/redakt...: Baltar, Valéria ...; Xun, Wei W; Chuang, Shu-Chun; Relton, Caroline; Ueland, Per Magn ...; Vollset, Stein E ...; visa fler...; Midttun, Øivind; Johansson, Matti ...; Slimani, Nadia; Jenab, Mazda; Clavel-Chapelon, ...; Boutron-Ruault, ...; Fagherazzi, Guy; Kaaks, Rudolf; Rohrmann, Sabine; Boeing, Heiner; Weikert, Corneli ...; Bueno-de-Mesquit ...; Boshuizen, Hendr ...; van Gils, Carla ...; Peeters, Petra H ...; Agudo, Antonio; Barricarte, Aure ...; Navarro, Carmen; Rodríguez, Laudi ...; Castaño, José Ma ...; Larrañaga, Nerea; Pérez, Maria Jos ...; Khaw, Kay-Tee; Wareham, Nick; Allen, Naomi E; Crowe, Francesca; Gallo, Valentina; Norat, Teresa; Tagliabue, Giova ...; Masala, Giovanna; Panico, Salvator ...; Sacerdote, Carlo ...; Tumino, Rosario; Trichopoulou, An ...; Lagiou, Pagona; Bamia, Christina; Rasmuson, Torgny; Hallmans, Göran; Roswall, Nina; Tjønneland, Anne; Riboli, Elio; Brennan, Paul; Vineis, Paolo; visa färre...

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Av lärosätet: Umeå universitet

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