Sökning: WFRF:(Yaras Tutku) > Associations Betwee...
Fältnamn | Indikatorer | Metadata |
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000 | 04569naa a2200505 4500 | |
001 | oai:DiVA.org:uu-531607 | |
003 | SwePub | |
008 | 240618s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5316072 URI |
024 | 7 | a https://doi.org/10.29399/npa.281272 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Tetik, Melikeu Dokuz Eylul Univ, Hlth Sci Inst, Dept Neurosci, Izmir, Turkiye.4 aut |
245 | 1 0 | a Associations Between Blood Levels of NLRP3 Inflammasome Components and Obsessive Compulsive Disorder |
264 | 1 | b Turk Noropsikiyatri Dernegi,c 2023 |
338 | a print2 rdacarrier | |
520 | a Introduction: Even though the effect of inflammation on pathogenesis of obsessive compulsive disorder (OCD) is known, information regarding the underlying mechanisms are yet to be revealed. The NLRP3 inflammasome complex is an important component of the innate immune system that initiates and mediates inflammatory response to a variety of stimuli. This study aims to inquire into a possible association between NLRP3 inflammasome complex and OCD. Methods: This case-control study included 103 participants (51 cases with OCD and 52 healthy controls). All participants were evaluated with the Yale Brown Obsessive Compulsive Scale, Hamilton Depression Scale, and Hewitt Multidimensional Perfectionism Scale. RNA and proteins were extracted from peripheral blood mononuclear cells. Expression of NLRP3 inflammasome components were determined using quantitative real-time polymerase chain reaction (PCR) and Western blotting. Levels of Serum IL-1beta and IL-18 cytokine were determined by ELISA. Results: NEK7 and CASP1 mRNA levels were significantly higher in OCD patients, compared to controls. Pro-caspase-1 protein levels were elevated, as well. Regression analysis showed that NEK7 mRNA and procaspase-1 protein levels can differentiate OCD and healthy control groups. Conclusion: Our results provide insight into the molecular alterations that could explain the inflammation-OCD association. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
653 | a ASC | |
653 | a caspase-1 | |
653 | a inflammasome | |
653 | a NEK7 | |
653 | a NLRP3 | |
653 | a obsessive-compulsive disorder | |
700 | 1 | a Direk, Neseu Istanbul Univ, Fac Med, Dept Psychiat, Istanbul, Turkiye.4 aut |
700 | 1 | a Uzgan, Betul Onderu Canakkale Onsekiz Mart Univ, Dept Biol, Canakkale, Turkiye.4 aut |
700 | 1 | a Aykac, Cansuu Dokuz Eylul Univ, Dept Psychiat, Fac Med, Izmir, Turkiye.4 aut |
700 | 1 | a Ekinci, Burcuu Dokuz Eylul Univ, Izmir Int Biomed & Genome Inst, Izmir, Turkiye.;Izmir Biomed & Genome Ctr, Izmir, Turkiye.4 aut |
700 | 1 | a Yaras, Tutkuu Dokuz Eylul Univ, Izmir Int Biomed & Genome Inst, Izmir, Turkiye.;Izmir Biomed & Genome Ctr, Izmir, Turkiye.4 aut |
700 | 1 | a Kuruoglu, Aykutu Dokuz Eylul Univ, Izmir Int Biomed & Genome Inst, Izmir, Turkiye.;Izmir Biomed & Genome Ctr, Izmir, Turkiye.4 aut |
700 | 1 | a Özel, Fatihu Uppsala universitet,Fysiologi och miljötoxikologi4 aut0 (Swepub:uu)fatoz136 |
700 | 1 | a Ermis, Cagatayu Dokuz Eylul Univ, Fac Med, Dept Child & Adolescent Psychiat, Izmir, Turkiye.4 aut |
700 | 1 | a Alkin, Tuncu Dokuz Eylul Univ, Hlth Sci Inst, Dept Neurosci, Izmir, Turkiye.;Dokuz Eylul Univ, Dept Psychiat, Fac Med, Izmir, Turkiye.4 aut |
700 | 1 | a Oktay, Yavuzu Dokuz Eylul Univ, Izmir Int Biomed & Genome Inst, Izmir, Turkiye.;Izmir Biomed & Genome Ctr, Izmir, Turkiye.;Dokuz Eylul Univ, Fac Med, Dept Med Biol, Izmir, Turkiye.4 aut |
710 | 2 | a Dokuz Eylul Univ, Hlth Sci Inst, Dept Neurosci, Izmir, Turkiye.b Istanbul Univ, Fac Med, Dept Psychiat, Istanbul, Turkiye.4 org |
773 | 0 | t Nöropsikiyatri Arşivid : Turk Noropsikiyatri Dernegig 60:1, s. 28-36q 60:1<28-36x 1300-0667 |
773 | 0 | t Archives of Neuropsychiatryd : Turk Noropsikiyatri Dernegig 60:1, s. 28-36q 60:1<28-36x 1309-4866 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-531607 |
856 | 4 8 | u https://doi.org/10.29399/npa.28127 |
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