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Sökning: WFRF:(Yazdanbakhsh Maria) > (2010) > Vitamin A supplemen...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004146naa a2200433 4500
001oai:lup.lub.lu.se:4753be4d-e39e-4c9d-950d-115291cf19ae
003SwePub
008160401s2010 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/15891402 URI
0247 a https://doi.org/10.1136/bmj.c11012 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Benn, Christine Stabell4 aut
2451 0a Vitamin A supplementation and BCG vaccination at birth in low birthweight neonates: two by two factorial randomised controlled trial
264 c 2010-03-09
264 1b BMJ,c 2010
520 a Objective To investigate the effect of vitamin A supplementation and BCG vaccination at birth in low birthweight neonates. Design Randomised, placebo controlled, two by two factorial trial. Setting Bissau, Guinea-Bissau. Participants 1717 low birthweight neonates born at the national hospital. Intervention Neonates who weighed less than 2.5 kg were randomly assigned to 25 000 IU vitamin A or placebo, as well as to early BCG vaccine or the usual late BCG vaccine, and were followed until age 12 months. Main outcome measure Mortality, calculated as mortality rate ratios (MRRs), after follow-up to 12 months of age for infants who received vitamin A supplementation compared with those who received placebo. Results No interaction was observed between vitamin A supplementation and BCG vaccine allocation (P=0.73). Vitamin A supplementation at birth was not significantly associated with mortality: the MRR of vitamin A supplementation compared with placebo, controlled for randomisation to "early BCG" versus "no early BCG" was 1.08 (95% CI 0.79 to 1.47). Stratification by sex revealed a significant interaction between vitamin A supplementation and sex (P=0.046), the MRR of vitamin A supplementation being 0.74 ( 95% CI 0.45 to 1.22) in boys and 1.42 (95% CI 0.94 to 2.15) in girls. When these data were combined with data from a complementary trial among normal birthweight neonates in Guinea-Bissau, the combined estimate of the effect of neonatal vitamin A supplementation on mortality was 1.08 ( 95% CI 0.87 to 1.33); 0.80 ( 95% CI 0.58 to 1.10) in boys and 1.41 ( 95% CI 1.04 to 1.90) in girls (P=0.01 for interaction between neonatal vitamin A and sex). Conclusions The combined results of this trial and the complementary trial among normal birthweight neonates have now shown that, overall, it would not be beneficial to implement a neonatal vitamin A supplementation policy in Guinea-Bissau. Worryingly, the trials show that vitamin A supplementation at birth can be harmful in girls. Previous studies and future trials should investigate the possibility that vitamin A supplementation has sex differential effects.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng
7001 a Fisker, Ane Baerent4 aut
7001 a Napirna, Bitiguida Mutna4 aut
7001 a Roth, Adamu Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)med-amr
7001 a Diness, Birgitte Rode4 aut
7001 a Lausch, Karen Rokkedal4 aut
7001 a Ravn, Henrik4 aut
7001 a Yazdanbakhsh, Maria4 aut
7001 a Rodrigues, Amabelia4 aut
7001 a Whittle, Hilton4 aut
7001 a Aaby, Peter4 aut
7102 a Klinisk mikrobiologi, Malmöb Forskargrupper vid Lunds universitet4 org
7730 t BMJ: British Medical Journald : BMJg 340q 340x 1756-1833
7730 t BMJd : BMJg 340q 340x 0959-8138x 1468-5833
8564 u http://dx.doi.org/10.1136/bmj.c1101x freey FULLTEXT
8564 u https://www.bmj.com/content/340/bmj.c1101.full.pdf
8564 8u https://lup.lub.lu.se/record/1589140
8564 8u https://doi.org/10.1136/bmj.c1101

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