Brain uptake and safety of Flutemetamol F 18 injection in Japanese subjects with probable Alzheimer's disease, subjects with amnestic mild cognitive impairment and healthy volunteers

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Zanette Michelle) > Brain uptake and sa...

Brain uptake and safety of Flutemetamol F 18 injection in Japanese subjects with probable Alzheimer's disease, subjects with amnestic mild cognitive impairment and healthy volunteers

Miki, Takami (författare): Osaka City Univ Hosp, Dept Geriatr, Abeno Ku, 5-7 Asahi Machi 1 Chome, Osaka, Japan.;Izumiotsu Municipal Hosp, Shimojyo Chou 16-1, Izumiotsu, Osaka 5950027, Japan.

Shimada, Hiroyuki (författare): Osaka City Univ Hosp, Dept Geriatr, Abeno Ku, 5-7 Asahi Machi 1 Chome, Osaka, Japan.

Kim, Jae-Seung (författare): Asan Med Ctr, Dept Nucl Med, 388-1 Pungnap 2 Dong, Seoul, South Korea.

visa fler...

Yamamoto, Yasuji (författare): Kobe Univ Hosp, Neuropsychiat Dept, Chuo Ku, 5-2 Kusunoki Cho 7 Chome, Kobe, Hyogo, Japan.

Sugino, Masakazu (författare): Aino Hosp, Ctr Geriatr Somatopsychol Care, 11-18 Takada Cho, Ibaraki, Osaka, Japan.

Kowa, Hisatomo (författare): Kobe Univ Hosp, Dept Neurol, Chuo Ku, 5-2 Kusunoki Cho 7 Chome, Kobe, Hyogo, Japan.

Heurling, Kerstin, 1982- (författare): Uppsala universitet,Radiologi,GE Healthcare, Uppsala, Sweden

Zanette, Michelle (författare): GE Healthcare, Marlborough, MA USA.

Sherwin, Paul F. (författare): GE Healthcare, Marlborough, MA USA.

Senda, Michio (författare): Inst Biomed Res & Innovat Hosp, Positron Med Dept, Chuo Ku, 2 Minatojima Minami Machi 2 Chome, Kobe, Hyogo, Japan.

visa färre...

Osaka City Univ Hosp, Dept Geriatr, Abeno Ku, 5-7 Asahi Machi 1 Chome, Osaka, Japan;Izumiotsu Municipal Hosp, Shimojyo Chou 16-1, Izumiotsu, Osaka 5950027, Japan. Osaka City Univ Hosp, Dept Geriatr, Abeno Ku, 5-7 Asahi Machi 1 Chome, Osaka, Japan. (creator_code:org_t)

2017-02-08
2017
Engelska.
Ingår i: Annals of Nuclear Medicine. - : Springer Science and Business Media LLC. - 0914-7187 .- 1864-6433. ; 31:3, s. 260-272

Relaterad länk:: https://link.springe...; visa fler...; https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Objective This Phase 2 study assessed the performance of positron emission tomography (PET) brain images made with Flutemetamol F 18 Injection in detecting beta-amyloid neuritic plaques in Japanese subjects. Methods Seventy subjects (25 with probable Alzheimer's disease (pAD), 20 with amnestic mild cognitive impairment (aMCI), and 25 cognitively normal healthy volunteers[HVs]) underwent PET brain imaging after intravenous Flutemetamol F 18 Injection (185 MBq). Images were interpreted as normal or abnormal for neuritic plaque density by each of five non-Japanese and five Japanese readers who were blinded to clinical data. The primary efficacy analysis (based on HV and pAD data) was the agreement of the non-Japanese readers' image interpretations with the clinical diagnosis, resulting in estimates of positive percent agreement (PPA; based on AD subjects; similar to sensitivity) and negative percent agreement (NPA; based on HVs; similar to specificity). Secondary analyses included PPA and NPA for the Japanese readers; inter-reader agreement (IRA); intra-reader reproducibility (IRR); quantitative image interpretations (standardized uptake value ratios [SUVRs]) by diagnostic subgroup; test-retest variability in five pAD subjects; and safety. Results PPA was 92% for all non-Japanese readers and ranged from 88 to 92% for the Japanese readers. NPA ranged from 96 to 100% for both the non-Japanese readers and the Japanese readers. The majority image interpretations (the interpretations made independently by ae3 of 5 readers) resulted in PPA values of 92 and 92% and NPA values of 100 and 96% for the non-Japanese and Japanese readers, respectively. IRA and IRR were strong. Composite SUVR values (mean of multiple regional values) allowed clear differentiation between pAD subjects and HVs. Test-retest variability ranged from 1.14 to 2.27%, and test-retest agreement of the blinded visual interpretations was 100% for all readers. Flutemetamol F 18 Injection was generally well tolerated. Conclusion The detection of brain neuritic plaques in Japanese subjects using [F-18]Flutemetamol PET images gave results highly consistent with clinical diagnosis, with non-Japanese and Japanese readers giving similar results. Inter-reader agreement and intra-reader reproducibility were high for both sets of readers. Visual delineation of abnormal and normal scans was corroborated by quantitative assessment, with low test-retest variability.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)

Nyckelord

[F-18] Flutemetamol
Alzheimer's disease
Radiotracer
beta-Amyloid

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Annals of Nuclear Medicine (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Miki, Takami; Shimada, Hiroyuk ...; Kim, Jae-Seung; Yamamoto, Yasuji; Sugino, Masakazu; Kowa, Hisatomo; visa fler...; Heurling, Kersti ...; Zanette, Michell ...; Sherwin, Paul F.; Senda, Michio; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Radiologi och bi ...

Artiklar i publikationen: Annals of Nuclea ...

Av lärosätet: Uppsala universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se