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Core-Shell Nanostructured Drug Delivery Platform Based on Biocompatible Metal-Organic Framework-Ligated Polyethyleneimine for Targeted Hepatocellular Carcinoma Therapy
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- Fytory, Mostafa (författare)
- Zewail City Sci & Technol, Ctr Mat Sci CMS, Nanomed Labs, Giza 12578, Egypt.;Beni Suef Univ, Fac Postgrad Studies Adv Sci PSAS, Mat Sci & Nanotechnol Dept, Bani Suwayf 62511, Egypt.
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- Mansour, Amira (författare)
- Zewail City Sci & Technol, Ctr Mat Sci CMS, Nanomed Labs, Giza 12578, Egypt.
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- El Rouby, Waleed M. A. (författare)
- Beni Suef Univ, Fac Postgrad Studies Adv Sci PSAS, Mat Sci & Nanotechnol Dept, Bani Suwayf 62511, Egypt.
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- Zewail City Sci & Technol, Ctr Mat Sci CMS, Nanomed Labs, Giza 12578, Egypt;Beni Suef Univ, Fac Postgrad Studies Adv Sci PSAS, Mat Sci & Nanotechnol Dept, Bani Suwayf 62511, Egypt. Zewail City Sci & Technol, Ctr Mat Sci CMS, Nanomed Labs, Giza 12578, Egypt. (creator_code:org_t)
- AMER CHEMICAL SOC, 2023
- 2023
- Engelska.
- Ingår i: ACS Omega. - : AMER CHEMICAL SOC. - 2470-1343. ; 8:23, s. 20779-20791
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Multifunctional nanosized metal-organic frameworks(NMOFs)have advanced rapidly over the past decade to develop drug deliverysystems (DDSs). These material systems still lack precise and selectivecellular targeting, as well as the fast release of the quantity ofdrugs that are simply adsorbed within and on the external surfaceof nanocarriers, which hinders their application in the drug delivery.Herein, we designed a biocompatible Zr-based NMOF with an engineeredcore and the hepatic tumor-targeting ligand, glycyrrhetinic acid graftedto polyethyleneimine (PEI) as the shell. The improved core-shellserves as a superior nanoplatform for efficient controlled and activedelivery of the anticancer drug doxorubicin (DOX) against hepaticcancer cells (HepG2 cells). In addition to their high loading capacityof 23%, the developed nanostructure DOX@NMOF-PEI-GA showed an acidicpH-stimulated response and extended the drug release time to 9 daysas well as enhanced the selectivity toward the tumor cells. Interestingly,the DOX-free nanostructures showed a minimal toxic effect on bothnormal human skin fibroblast (HSF) and hepatic cancer cell line (HepG2),but the DOX-loaded nanostructures exhibited a superior killing effecttoward the hepatic tumor, thus opening the way for the active drugdelivery and achieving efficient cancer therapy applications.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
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- Zhang, Xiaorong
- Bier, Frank
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