The endogenous opioid system in human alcoholics: molecular adaptations in brain areas involved in cognitive control of addiction

The endogenous opioid system in human alcoholics : molecular adaptations in brain areas involved in cognitive control of addiction

Bazov, Igor (author): Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Molecular neuropsychopharmacology,Uppsala University, Uppsala, Sweden

Kononenko, Olga (author): Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Molecular neuropsychopharmacology,Uppsala University, Uppsala, Sweden; Bogomoletz Institute of Physiology, Kiev, Ukrain

Watanabe, Hiroyuki (author): Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Molecular neuropsychopharmacology,Uppsala University, Uppsala, Sweden

Sarkisyan, Daniil (author): Financial University under the Government of the Russian Federation, Moscow, Russian Federation

Taqi, Malik Mumtaz (author): Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Molecular neuropsychopharmacology,Uppsala University, Uppsala, Sweden

Hussain, Muhammad Zubair (author): Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Molecular neuropsychopharmacology,Uppsala University, Uppsala, Sweden

Nyberg, Fred (author): Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Uppsala University, Uppsala, Sweden

Yakovleva, Tatjana (author): Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Molecular neuropsychopharmacology,Uppsala University, Uppsala, Sweden

Bakalkin, Georgy (author): Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Uppsala University, Uppsala, Sweden

(creator_code:org_t)

2011-09-28
2013
English.
In: Addiction Biology. - : Wiley. - 1355-6215 .- 1369-1600. ; 18:1, s. 161-169

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; https://urn.kb.se/re...; show less...

Abstract Subject headings

The endogenous opioid system (EOS) plays a critical role in addictive processes. Molecular dysregulations in this system may be specific for different stages of addiction cycle and neurocircuitries involved and therefore may differentially contribute to the initiation and maintenance of addiction. Here we evaluated whether the EOS is altered in brain areas involved in cognitive control of addiction including the dorsolateral prefrontal cortex (dl-PFC), orbitofrontal cortex (OFC) and hippocampus in human alcohol-dependent subjects. Levels of EOS mRNAs were measured by quantitative reverse transcription-polymerase chain reaction (qRT-PCR), and levels of dynorphins by radioimmunoassay (RIA) in post-mortem specimens obtained from 14 alcoholics and 14 controls. Prodynorphin mRNA and dynorphins in dl-PFC, κ-opioid receptor mRNA in OFC and dynorphins in hippocampus were up-regulated in alcoholics. No significant changes in expression of proenkephalin, and µ- and δ-opioid receptors were evident; pro-opiomelanocortin mRNA levels were below the detection limit. Activation of the κ-opioid receptor by up-regulated dynorphins in alcoholics may underlie in part neurocognitive dysfunctions relevant for addiction and disrupted inhibitory control.

By the author/editor: Bazov, Igor; Kononenko, Olga; Watanabe, Hiroyu ...; Kuntić, Vesna; Sarkisyan, Danii ...; Taqi, Malik Mumt ...; show more...; Hussain, Muhamma ...; Nyberg, Fred; Yakovleva, Tatja ...; Bakalkin, Georgy; show less...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Biochemistry and ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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