WFRF:(von Euler Anne)
Search: WFRF:(von Euler Anne) > Synaptic expression...
- 2 of 12
- Previous record
- Next record
- To hitlist
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04030nam a2200373 4500 | |
| 001 | oai:DiVA.org:su-142315 | |
| 003 | SwePub | |
| 008 | 170428| | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1423152 URI |
| 040 | a (SwePub)su | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a vet2 swepub-contenttype |
| 072 | 7 | a ovr2 swepub-publicationtype |
| 100 | 1 | a Behm, Mikaela,d 1986-u Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut0 (Swepub:su)mibe7703 |
| 245 | 1 0 | a Synaptic expression and regulation of miRNA editing in the brain |
| 338 | a print2 rdacarrier | |
| 520 | a In the brain, sophisticated networks of RNA regulatory events tightly control gene expression in order to achieve proper brain function. We and others have previously shown that several miRNAs, encoded within the miR-379-410 cluster, are subjected to A-to-I RNA editing. In the present study we conclude these edited miRNAs to be transcribed as a single long consecutive transcript, however the maturation into functional forms of miRNAs is regulated individually. In seven of the miRNAs, subjected to editing, we analyze how editing relates to miRNA maturation. Of particular interest has been maturation of miR-381-3p and miR-376b-3p, both important for neuronal plasticity, dendrite outgrowth and neuronal homeostasis. Most of the edited miRNAs from the cluster, are highly edited in their unprocessed primary transcript, including miR-381-3p and miR-376b-3p. However, editing in miR-381-3p is almost entirely absent in the mature form, while editing is increased in the mature form of miR-376b-3p compared to the primary transcript. We propose that ADAR1 positively influences the maturation of pri-miR-381 in an editing independent manner. In pri-miR-376b we hypothesize that ADAR1 and ADAR2 competes for editing, and while ADAR2 inhibits miRNA maturation, ADAR1 editing is frequently present in the mature miR-376b-3p. We further show that miR-381-3p and miR-376b-3p regulate the dendritically expressed Pumilio 2 (Pum2) protein. By next generation RNA sequencing (NGS RNA-seq) on purified synaptoneurosomes, we show that miR-381-3p is highly expressed at the synapse, suggesting its functional role in locally regulating Pum2. Furthermore, we identify a set of highly expressed miRNAs at the synapse, which may act locally to target synaptic mRNAs. | |
| 650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
| 653 | a Molecular Biology | |
| 653 | a molekylärbiologi | |
| 700 | 1 | a Fritzell, Kajsau Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut0 (Swepub:su)kafr3086 |
| 700 | 1 | a Pessa, Heli4 aut |
| 700 | 1 | a Mackowiak, Sebastianu Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut0 (Swepub:su)smack |
| 700 | 1 | a Ekdahl, Ylva4 aut |
| 700 | 1 | a Kang, Wenjingu Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut0 (Swepub:su)wkang |
| 700 | 1 | a Biryukova, Innau Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut0 (Swepub:su)einna |
| 700 | 1 | a von Euler, Anneu Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut0 (Swepub:su)avone |
| 700 | 1 | a Visa, Neusu Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut0 (Swepub:su)neus |
| 700 | 1 | a Friedländer, Marcu Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut0 (Swepub:su)mfrie |
| 700 | 1 | a Öhman, Marieu Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut0 (Swepub:su)marohm |
| 710 | 2 | a Stockholms universitetb Institutionen för molekylär biovetenskap, Wenner-Grens institut4 org |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-142315 |
To the university's database
- 2 of 12
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Behm, Mikaela, 1 ...
- Fritzell, Kajsa
- Pessa, Heli
- Mackowiak, Sebas ...
- Ekdahl, Ylva
- Kang, Wenjing
- show more...
- Biryukova, Inna
- von Euler, Anne
- Visa, Neus
- Friedländer, Mar ...
- Öhman, Marie
- show less...
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- By the university
- Stockholm University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
