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Sökning: (WFRF:(Anne M.)) srt2:(2010-2014) > (2014) > Polymorphisms of He...

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FältnamnIndikatorerMetadata
00006479naa a2200997 4500
001oai:lup.lub.lu.se:a5e6fcfa-7f18-4383-ac8c-f4012d900737
003SwePub
008160401s2014 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:127671992
009oai:gup.ub.gu.se/188108
0247 a https://lup.lub.lu.se/record/42042162 URI
0247 a https://doi.org/10.1002/ijc.283572 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1276719922 URI
0247 a https://gup.ub.gu.se/publication/1881082 URI
040 a (SwePub)lud (SwePub)kid (SwePub)gu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Companioni, Osmel4 aut
2451 0a Polymorphisms of Helicobacter pylori signaling pathway genes and gastric cancer risk in the European Prospective Investigation into Cancer-Eurgast cohort
264 c 2013-08-13
264 1b Wiley,c 2014
520 a Helicobacter pylori is a recognized causal factor of noncardia gastric cancer (GC). Lipopolysaccharide and peptidoglycan of this bacterium are recognized by CD14, TLR4 and NOD2 human proteins, while NFKB1 activates the transcription of pro-inflammatory cytokines to elicit an immune response. Single nucleotide polymorphisms (SNPs) in these genes have been associated with GC in different populations. We genotyped 30 SNPs of these genes, in 365 gastric adenocarcinomas and 1,284 matched controls from the European Prospective Investigation into Cancer cohort. The association with GC and its histological and anatomical subtypes was analyzed by logistic regression and corrected for multiple comparisons. Using a log-additive model, we found a significant association between SNPs in CD14, NOD2 and TLR4 with GC risk. However, after applying the multiple comparisons tests only the NOD2 region remained significant (p=0.009). Analysis according to anatomical subtypes revealed NOD2 and NFKB1 SNPs associated with noncardia GC and CD14 SNPs associated with cardia GC, while analysis according to histological subtypes showed that CD14 was associated with intestinal but not diffuse GC. The multiple comparisons tests confirmed the association of NOD2 with noncardia GC (p=0.0003) and CD14 with cardia GC (p=0.01). Haplotype analysis was in agreement with single SNP results for NOD2 and CD14 genes. From these results, we conclude that genetic variation in NOD2 associates with noncardia GC while variation in CD14 is associated with cardia GC. What's new? Variations in immune genes appear to play an important role in determining susceptibility to gastric cancer linked to Helicobacter pylori colonization of gastric mucosa. However, little is known about the influence of variation on anatomical localization and histological subtype of this malignancy. The results of this study first confirm that NOD2 and CD14, which encode proteins that recognize H. pylori lipopolysaccharide and peptidoglycan, are significantly associated with gastric cancer risk and second indicate that NOD2 associates with noncardia and CD14 with cardia gastric cancer. The differential effects of variation on the anatomical localization of disease warrant further investigation.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653 a gastric cancer
653 a genetic susceptibility
653 a Helicobacter pylori
653 a NOD2
653 a CD14
653 a gastric cancer;genetic susceptibility;Helicobacter pylori;NOD2;CD14
7001 a Bonet, Catalina4 aut
7001 a Munoz, Xavier4 aut
7001 a Weiderpass, Elisabeteu Karolinska Institutet4 aut
7001 a Panico, Salvatore4 aut
7001 a Tumino, Rosario4 aut
7001 a Palli, Domenico4 aut
7001 a Agnoli, Claudia4 aut
7001 a Vineis, Paolo4 aut
7001 a Boutron-Ruault, Marie-Christine4 aut
7001 a Racine, Antoine4 aut
7001 a Clavel-Chapelon, Francoise4 aut
7001 a Travis, Ruth C.4 aut
7001 a Khaw, Kay-Tee4 aut
7001 a Riboli, Elio4 aut
7001 a Murphy, Neil4 aut
7001 a Vergnaud, Anne-Claire4 aut
7001 a Trichopoulou, Antonia4 aut
7001 a Benetou, Vassiliki4 aut
7001 a Trichopoulos, Dimitrios4 aut
7001 a Lund, Eiliv4 aut
7001 a Johansen, Dortheu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine4 aut0 (Swepub:lu)kirm-djo
7001 a Lindkvist, Björnu Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xlibjo
7001 a Johansson, Mattias4 aut
7001 a Sund, Malin4 aut
7001 a Ardanaz, Eva4 aut
7001 a Sanchez-Cantalejo, Emilio4 aut
7001 a Huerta, Jose M.4 aut
7001 a Dorronsoro, Miren4 aut
7001 a Ramon Quiros, Jose4 aut
7001 a Tjonneland, Anne4 aut
7001 a Mortensen, Lotte Maxild4 aut
7001 a Overvad, Kim4 aut
7001 a Chang-Claude, Jenny4 aut
7001 a Rizzato, Cosmeri4 aut
7001 a Boeing, Heiner4 aut
7001 a De Mesquita, H. Bas Bueno4 aut
7001 a Siersema, Peter4 aut
7001 a Peeters, Petra H. M.4 aut
7001 a Numans, Mattijs E.4 aut
7001 a Carneiro, Fatima4 aut
7001 a Licaj, Idlir4 aut
7001 a Freisling, Heinz4 aut
7001 a Sala, Nuria4 aut
7001 a Gonzalez, Carlos A.4 aut
7102 a Karolinska Institutetb Institutionen för kliniska vetenskaper, Malmö4 org
7730 t International Journal of Cancerd : Wileyg 134:1, s. 92-101q 134:1<92-101x 0020-7136x 1097-0215
8564 u http://dx.doi.org/10.1002/ijc.28357x freey FULLTEXT
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.28357
8564 8u https://lup.lub.lu.se/record/4204216
8564 8u https://doi.org/10.1002/ijc.28357
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:127671992
8564 8u https://gup.ub.gu.se/publication/188108

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