Post-G WAS gene-environment interplay in breast cancer: results from the Breast and Prostate Cancer Cohort Consortium and a meta-analysis on 79 000 women

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Fältnamn	Indikatorer	Metadata
000		04505naa a2200769 4500
001		oai:DiVA.org:umu-96615
003		SwePub
008		141124s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-966152 URI
024	7	a https://doi.org/10.1093/hmg/ddu2232 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Barrdahl, Myrto4 aut
245	1 0	a Post-G WAS gene-environment interplay in breast cancer :b results from the Breast and Prostate Cancer Cohort Consortium and a meta-analysis on 79 000 women
264		c 2014-05-08
264	1	b Oxford University Press (OUP),c 2014
338		a print2 rdacarrier
520		a We studied the interplay between 39 breast cancer (BC) risk SNPs and established BC risk (body mass index, height, age at menarche, parity, age at menopause, smoking, alcohol and family history of BC) and prognostic factors (TNM stage, tumor grade, tumor size, age at diagnosis, estrogen receptor status and progesterone receptor status) as joint determinants of BC risk. We used a nested case-control design within the National Cancer Institute's Breast and Prostate Cancer Cohort Consortium (BPC3), with 16 285 BC cases and 19 376 controls. We performed stratified analyses for both the risk and prognostic factors, testing for heterogeneity for the risk factors, and case-case comparisons for differential associations of polymorphisms by subgroups of the prognostic factors. We analyzed multiplicative interactions between the SNPs and the risk factors. Finally, we also performed a meta-analysis of the interaction ORs from BPC3 and the Breast Cancer Association Consortium. After correction for multiple testing, no significant interaction between the SNPs and the established risk factors in the BPC3 study was found. The meta-analysis showed a suggestive interaction between smoking status and SLC4A7-rs4973768 (P-interaction = 8.84 x 10(-4)) which, although not significant after considering multiple comparison, has a plausible biological explanation. In conclusion, in this study of up to almost 79 000 women we can conclusively exclude any novel major interactions between genome-wide association studies hits and the epidemiologic risk factors taken into consideration, but we propose a suggestive interaction between smoking status and SLC4A7-rs4973768 that if further replicated could help our understanding in the etiology of BC.
700	1	a Canzian, Federico4 aut
700	1	a Joshi, Amit D.4 aut
700	1	a Travis, Ruth C.4 aut
700	1	a Chang-Claude, Jenny4 aut
700	1	a Auer, Paul L.4 aut
700	1	a Gapstur, Susan M.4 aut
700	1	a Gaudet, Mia4 aut
700	1	a Diver, W. Ryan4 aut
700	1	a Henderson, Brian E.4 aut
700	1	a Haiman, Christopher A.4 aut
700	1	a Schumacher, Fredrick R.4 aut
700	1	a Le Marchand, Loic4 aut
700	1	a Berg, Christine D.4 aut
700	1	a Chanock, Stephen J.4 aut
700	1	a Hoover, Robert N.4 aut
700	1	a Rudolph, Anja4 aut
700	1	a Ziegler, Regina G.4 aut
700	1	a Giles, Graham G.4 aut
700	1	a Baglietto, Laura4 aut
700	1	a Severi, Gianluca4 aut
700	1	a Hankinson, Susan E.4 aut
700	1	a Lindstroem, Sara4 aut
700	1	a Willet, Walter4 aut
700	1	a Hunter, David J.4 aut
700	1	a Buring, Julie E.4 aut
700	1	a Lee, I-Min4 aut
700	1	a Zhang, Shumin4 aut
700	1	a Dossus, Laure4 aut
700	1	a Cox, David G.4 aut
700	1	a Khaw, Kay-Tee4 aut
700	1	a Lund, Eiliv4 aut
700	1	a Naccarati, Alessio4 aut
700	1	a Peeters, Petra H.4 aut
700	1	a Ramon Quiros, J.4 aut
700	1	a Riboli, Elio4 aut
700	1	a Sund, Malin,d 1972-u Umeå universitet,Kirurgi4 aut0 (Swepub:umu)masu0021
700	1	a Trichopoulos, Dimitrios4 aut
700	1	a Prentice, Ross L.4 aut
700	1	a Kraft, Peter4 aut
700	1	a Kaaks, Rudolf4 aut
700	1	a Campa, Daniele4 aut
710	2	a Umeå universitetb Kirurgi4 org
773	0	t Human Molecular Geneticsd : Oxford University Press (OUP)g 23:19, s. 5260-5270q 23:19<5260-5270x 0964-6906x 1460-2083
856	4	u https://academic.oup.com/hmg/article-pdf/23/19/5260/17260677/ddu223.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-96615
856	4 8	u https://doi.org/10.1093/hmg/ddu223

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Av författaren/redakt...: Barrdahl, Myrto; Canzian, Federic ...; Joshi, Amit D.; Travis, Ruth C.; Chang-Claude, Je ...; Auer, Paul L.; visa fler...; Gapstur, Susan M ...; Gaudet, Mia; Diver, W. Ryan; Henderson, Brian ...; Haiman, Christop ...; Schumacher, Fred ...; Le Marchand, Loi ...; Berg, Christine ...; Chanock, Stephen ...; Hoover, Robert N ...; Rudolph, Anja; Ziegler, Regina ...; Giles, Graham G.; Baglietto, Laura; Severi, Gianluca; Hankinson, Susan ...; Lindstroem, Sara; Willet, Walter; Hunter, David J.; Buring, Julie E.; Lee, I-Min; Zhang, Shumin; Dossus, Laure; Cox, David G.; Khaw, Kay-Tee; Lund, Eiliv; Naccarati, Aless ...; Peeters, Petra H ...; Ramon Quiros, J.; Riboli, Elio; Sund, Malin, 197 ...; Trichopoulos, Di ...; Prentice, Ross L ...; Kraft, Peter; Kaaks, Rudolf; Campa, Daniele; visa färre...

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Av lärosätet: Umeå universitet

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