Cryo-XPS for surface characterization of nanomedicines

Nanoparticles used for medical applications commonly possess coatings or surface functionalities intended to provide specific behavior in vivo, for example, the use of PEG to provide stealth properties. Direct, quantitative measurement of the surface chemistry and composition of such systems in a hydrated environment has thus far not been demonstrated, yet such measurements are of great importance for the development of nanomedicine systems. Here we demonstrate the first use of cryo-XPS for the measurement of two PEG-functionalized nanomedicines: a polymeric drug delivery system and a lipid nanoparticle mRNA carrier. The observed differences between cryo-XPS and standard XPS measurements indicate the potential of cryo-XPS for providing quantitative measurements of such nanoparticle systems in hydrated conditions.

Pei, YiwenNational Physical Laboratory, Teddington, UK (författare)
Shchukarev, AndreyUmeå universitet,Kemiska institutionen(Swepub:umu)ansh0001 (författare)
Ramstedt, MadeleineUmeå universitet,Kemiska institutionen(Swepub:umu)maerat95 (författare)
Marques, Sara S.Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal (författare)
Segundo, Marcela A.Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal (författare)
Parot, JeremieDepartment of Biotechnology and Nanomedicine, SINTEF Industry, Trondheim, Norway (författare)
Molska, AlicjaDepartment of Biotechnology and Nanomedicine, SINTEF Industry, Trondheim, Norway (författare)
Borgos, Sven E.Department of Biotechnology and Nanomedicine, SINTEF Industry, Trondheim, Norway (författare)
Shard, Alexander G.National Physical Laboratory, Teddington, UK (författare)
Minelli, CaterinaNational Physical Laboratory, Teddington, UK (författare)
National Physical Laboratory, Teddington, UKKemiska institutionen (creator_code:org_t)

Ingår i:Journal of Physical Chemistry A: American Chemical Society (ACS)127:39, s. 8220-82271089-56391520-5215

Av författaren/redakt...: Cant, David J. H ...; Pei, Yiwen; Shchukarev, Andr ...; Ramstedt, Madele ...; Marques, Sara S.; Segundo, Marcela ...; visa fler...; Parot, Jeremie; Molska, Alicja; Borgos, Sven E.; Shard, Alexander ...; Minelli, Caterin ...; visa färre...

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