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AMNE:(MEDICAL AND HEALTH SCIENCES Clinical Medicine Radiology, Nuclear Medicine and Medical Imaging)
 

Sökning: AMNE:(MEDICAL AND HEALTH SCIENCES Clinical Medicine Radiology, Nuclear Medicine and Medical Imaging) > (2010-2014) > Quantitative evalua...

  • Virén, TuomasDepartment of Physics and Mathematics, University of Eastern Finland, Kuopio, Finland (författare)

Quantitative evaluation of spontaneously and surgically repaired rabbit articular cartilage using intra-articular ultrasound method in situ.

  • Artikel/kapitelEngelska2010

Förlag, utgivningsår, omfång ...

  • Elsevier,2010
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-105422
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-105422URI
  • https://doi.org/10.1016/j.ultrasmedbio.2010.02.015DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska &language:-1_t

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • During the last decade, a major effort has been devoted to developing surgical methods for repairing localized articular cartilage lesions. Despite some promising results no ultimate breakthrough in surgical cartilage repair has been achieved. Improvements in repair techniques would benefit from more sensitive and quantitative methods for long-term follow-up of cartilage healing. In this study, the potential of a new ultrasound technique for detecting the compositional and structural changes in articular cartilage after surgery, using recombinant human type II collagen gel and spontaneous repair was, investigated. Rabbit knee joints containing intact (n = 13) and surgically (n = 8) or spontaneously (n = 5) repaired tissue were imaged in situ at 6 months after the operation using a clinical intravascular high-frequency (40 MHz) ultrasound device. Based on the ultrasound raw data, ultrasound reflection coefficient (R), integrated ultrasound reflection coefficient (IRC), apparent integrated backscattering coefficient (AIB) and ultrasound roughness index (URI) were determined for each sample. URI was significantly higher in both repair groups than in intact cartilage (p < 0.05). The reflection parameters (R and IRC) were significantly lower in surgically repaired cartilage (p < 0.05) than in intact cartilage. Furthermore, AIB was significantly higher in surgically repaired cartilage than in intact tissue (p < 0.05). To conclude, the integrity of the rabbit articular cartilage repair could be quantitatively evaluated with the nondestructive ultrasound approach. In addition, clinically valuable qualitative information on the changes in cartilage integration, structure and composition could be extracted from the ultrasound images. In the present study, the structure and properties of repaired tissue were inferior to native tissue at 6 months after the operation. The applied ultrasound device and probes are FDA approved and, thus, applicable for the quantitative in vivo evaluation of human articular cartilage.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Saarakkala, SimoDepartment of Physics and Mathematics, University of Eastern Finland, Kuopio, Finland (författare)
  • Jurvelin, JukkaDepartment of Physics and Mathematics, University of Eastern Finland, Kuopio, Finland (författare)
  • Pulkkinen, HerttaSchool of Medicine Institute of Biomedicine, Anatomy, University of Eastern Finland, Kuopio, Finland (författare)
  • Tiitu, VirpiSchool of Medicine Institute of Biomedicine, Anatomy, University of Eastern Finland, Kuopio, Finland (författare)
  • Valonen, PiiaSchool of Medicine Institute of Biomedicine, Anatomy, University of Eastern Finland, Kuopio, Finland (författare)
  • Kiviranta, IlkkaDepartment of Orthopaedics and Traumatology, University of Helsinki, Helsinki, Finland (författare)
  • Lammi, Mikko,1961-Department of Biosciences, University of Eastern Finland, Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group(Swepub:umu)mila0077 (författare)
  • Töyräs, JuhaDepartment of Physics and Mathematics, University of Eastern Finland, Kuopio, Finland; Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland (författare)
  • Department of Physics and Mathematics, University of Eastern Finland, Kuopio, FinlandSchool of Medicine Institute of Biomedicine, Anatomy, University of Eastern Finland, Kuopio, Finland (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Ultrasound in Medicine and Biology: Elsevier36:5, s. 833-8391879-291X0301-5629

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