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Search: L773:0179 1958 OR L773:1432 1262 > (2010-2014) > Association study i...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003727naa a2200505 4500
001oai:lup.lub.lu.se:3502227a-615b-4b5e-99a8-0e67e8379ea5
003SwePub
008160401s2013 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/36746202 URI
0247 a https://doi.org/10.1007/s00384-012-1541-42 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Lascorz, Jess4 aut
2451 0a Association study identifying polymorphisms in CD47 and other extracellular matrix pathway genes as putative prognostic markers for colorectal cancer
264 c 2012-07-28
264 1b Springer Science and Business Media LLC,c 2013
520 a We identified recently the extracellular matrix (ECM) receptor interaction pathway as a consistently overrepresented category among gene expression profiling studies on colorectal cancer (CRC) prognosis. Putative regulatory single nucleotide polymorphisms (SNPs) in genes from the ECM pathway were genotyped in 613 CRC patients from Northern Germany (PopGen cohort) and tested for association with disease progression and survival. The eSNP (SNP associated with expression) rs12695175 in CD47 associated with CRC specific survival (HR = 2.18, 95 % CI 1.10-4.33, CC versus AA) and with overall survival (HR = 1.99, 95 % CI 1.04-3.81, CC versus AA). This association remained significant after adjustment for age at diagnosis, tumour stage (T) and lymph node status (N). Three polymorphisms in CD47 were associated with distant metastasis in a dominant model: rs9879947 and rs3206652 in the 3'-UTR (OR = 1.64, 95 % CI 1.01-2.64 and OR = 1.88, 95 % CI 1.27-2.80, respectively) and the eSNP rs3804639 (OR = 1.73, 95 % CI 1.17-2.57). The novel associations of eSNPs in CD47 with worse survival and distant metastasis should be confirmed by additional studies, since increased expression of this gene has recently been shown to be an indicator of poor prognosis in cancer patients.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
653 a CD47
653 a Colorectal cancer
653 a Extracellular matrix
653 a Prognosis
653 a Survival
7001 a Bevier, Melanie4 aut
7001 a v. Schoenfels, Witigo4 aut
7001 a Kalthoff, Holger4 aut
7001 a Aselmann, Heiko4 aut
7001 a Beckmann, Jan4 aut
7001 a Egberts, Jan4 aut
7001 a Buch, Stephan4 aut
7001 a Becker, Thomas4 aut
7001 a Schreiber, Stefan4 aut
7001 a Hampe, Jochen4 aut
7001 a Hemminki, Kariu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-khk
7001 a Schafmayer, Clemens4 aut
7001 a Försti, Astau Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-asf
7102 a Allmänmedicin och klinisk epidemiologib Forskargrupper vid Lunds universitet4 org
7730 t International Journal of Colorectal Diseased : Springer Science and Business Media LLCg 28:2, s. 173-181q 28:2<173-181x 1432-1262x 0179-1958
8564 u http://dx.doi.org/10.1007/s00384-012-1541-4y FULLTEXT
8564 8u https://lup.lub.lu.se/record/3674620
8564 8u https://doi.org/10.1007/s00384-012-1541-4

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