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Differences in surv...
Omega-3 and omega-6 polyunsaturated fatty acid biomarkers and sleep a pooled analysis of cohort studies On behalf of the Fatty Acids and Outcomes Research Consortium (FORCE).
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Murphy, Rachel A (författare)
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Tintle, Nathan (författare)
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Harris, William S (författare)
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visa fler...
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Darvishian, Maryam (författare)
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Marklund, Matti (författare)
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Virtanen, Jyrki K (författare)
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Hantunen, Sari (författare)
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de Mello, Vanessa D (författare)
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Tuomilehto, Jaakko (författare)
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Lindström, Jaana (författare)
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Bolt, Matthew A (författare)
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Brouwer, Ingeborg A (författare)
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Wood, Alexis C (författare)
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Senn, Mackenzie (författare)
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Redline, Susan (författare)
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Tsai, Michael Y (författare)
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Gudnason, Vilmundur (författare)
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Eiriksdottir, Gudny (författare)
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Lindberg, Eva (författare)
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Shadyab, Aladdin H (författare)
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Liu, Buyun (författare)
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Carnethon, Mercedes (författare)
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Uusitupa, Matti (författare)
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Djousse, Luc (författare)
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Risérus, Ulf, 1967- (författare)
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Lind, Lars (författare)
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van Dam, Rob M (författare)
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Koh, Woon-Puay (författare)
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Shi, Peilin (författare)
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Siscovick, David (författare)
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Lemaitre, Rozenn N (författare)
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Mozaffarian, Dariush (författare)
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(utgivare)
- Oxford University Press (OUP), 2022
- 2022
- Engelska.
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Ingår i: American Journal of Clinical Nutrition. - 0002-9165. ; 115:3, 864-876
Abstract
Ämnesord
Stäng
- BACKGROUND: n-3 and n-6 polyunsaturated fatty acids (PUFAs) have physiologic roles in sleep processes, but little is known regarding circulating n-3 and n-6 PUFA and sleep parameters. OBJECTIVES: To assess associations between biomarkers of n-3 and n-6 PUFA intake with self-reported sleep duration and difficulty falling sleeping in the Fatty Acids and Outcome Research Consortium. METHODS: Harmonized, de novo, individual-level analyses were performed and pooled across 12 cohorts. Participants were between 35 to 96 years old and from 5 nations. Circulating measures included alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), docosahexaenoic acid (DHA), EPA + DPA + DHA, linoleic acid and arachidonic acid. Sleep duration (10 cohorts, N = 18,791) was categorized as short (≤6 hours), 7-8 hours (reference) or long (9 + hours). Difficulty falling sleeping (8 cohorts, N = 12,500) was categorized as yes or no. Associations between PUFAs, sleep duration, and difficulty falling sleeping were assessed by cross-sectional multinomial logistic regression using standardized protocols and covariates. Cohort-specific multivariable-adjusted odds ratios (ORs) per quintile of PUFAs were pooled with inverse-variance weighted meta-analysis. RESULTS: In pooled analysis adjusted for sociodemographics and health status, participants with higher very long-chain n-3 PUFAs were less likely to have long sleep duration. Comparing top vs. bottom quintiles, the multivariable-adjusted OR (95% confidence interval, CI) for long-sleep was 0.78 (0.65, 0.95) for DHA and for EPA + DPA + DHA, 0.76 (0.63, 0.93). Significant associations were not identified for ALA and n-6 PUFA with short sleep duration, or difficulty falling sleeping. CONCLUSIONS: Participants with higher levels of very long-chain n-3 PUFAs were less likely to have long sleep duration. While objective biomarkers reduce recall bias and misclassification, the cross-sectional design limits assessment of the temporal nature of this relationship. These novel findings across 12 cohorts highlight the need for experimental and biological assessments of very long-chain n-3 PUFAs and sleep duration.
Ämnesord
- Medical and Health Sciences (hsv)
- Health Sciences (hsv)
- Nutrition and Dietetics (hsv)
- Medicin och hälsovetenskap (hsv)
- Hälsovetenskaper (hsv)
- Näringslära (hsv)
Genre
- government publication (marcgt)
Nyckelord
- biomarkers
- diet
- fatty acids
- omega-3
- public health
- sleep quality
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