Sökning: WFRF:(Chatterjee Nilanjan) > Genome-wide associa...
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000 | 11676naa a2201225 4500 | |
001 | oai:DiVA.org:uu-422339 | |
003 | SwePub | |
008 | 201013s2012 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-60172 | |
009 | oai:prod.swepub.kib.ki.se:125557180 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4223392 URI |
024 | 7 | a https://doi.org/10.1007/s00439-012-1212-02 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-601722 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1255571802 URI |
040 | a (SwePub)uud (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Rajaraman, Preethau NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,DHHS, Bethesda, MD 20892 USA.;NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut |
245 | 1 0 | a Genome-wide association study of glioma and meta-analysis |
264 | c 2012-08-11 | |
264 | 1 | b SPRINGER,c 2012 |
338 | a print2 rdacarrier | |
520 | a Gliomas account for approximately 80 % of all primary malignant brain tumors and, despite improvements in clinical care over the last 20 years, remain among the most lethal tumors, underscoring the need for gaining new insights that could translate into clinical advances. Recent genome-wide association studies (GWAS) have identified seven new susceptibility regions. We conducted a new independent GWAS of glioma using 1,856 cases and 4,955 controls (from 14 cohort studies, 3 case-control studies, and 1 population-based case-only study) and found evidence of strong replication for three of the seven previously reported associations at 20q13.33 (RTEL), 5p15.33 (TERT), and 9p21.3 (CDKN2BAS), and consistent association signals for the remaining four at 7p11.2 (EGFR both loci), 8q24.21 (CCDC26) and 11q23.3 (PHLDB1). The direction and magnitude of the signal were consistent for samples from cohort and case-control studies, but the strength of the association was more pronounced for loci rs6010620 (20q,13.33; RTEL) and rs2736100 (5p15.33, TERT) in cohort studies despite the smaller number of cases in this group, likely due to relatively more higher grade tumors being captured in the cohort studies. We further examined the 85 most promising single nucleotide polymorphism (SNP) markers identified in our study in three replication sets (5,015 cases and 11,601 controls), but no new markers reached genome-wide significance. Our findings suggest that larger studies focusing on novel approaches as well as specific tumor subtypes or subgroups will be required to identify additional common susceptibility loci for glioma risk. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Melin, Beatrice Su Umeå universitet,Onkologi,Umea Univ, Dept Radiat Sci, Umea, Sweden.,Univ Texas MD Anderson Canc Ctr, Dept Biostat, Orlando, TX USA.4 aut0 (Swepub:umu)bema0010 |
700 | 1 | a Wang, Zhaomingu NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.;NCI, Core Genotyping Facil, SAIC Frederick Inc, Gaithersburg, MD USA.4 aut |
700 | 1 | a McKean-Cowdin, Robertau Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.4 aut |
700 | 1 | a Michaud, Dominique S.u Brown Univ, Div Biol & Med, Dept Epidemiol, Providence, RI 02912 USA.;Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England.4 aut |
700 | 1 | a Wang, Sophia S.u City Hope Natl Med Ctr, Div Canc Etiol, Dept Populat Sci, Duarte, CA USA.;City Hope Natl Med Ctr, Beckman Res Inst, Duarte, CA 91010 USA.4 aut |
700 | 1 | a Bondy, Melissau Baylor Coll Med, Houston, TX 77030 USA.4 aut |
700 | 1 | a Houlston, Richardu Inst Canc Res, Div Genet & Epidemiol, Sutton, Surrey, England.4 aut |
700 | 1 | a Jenkins, Robert B.u Mayo Clin, Rochester, MN USA.4 aut |
700 | 1 | a Wrensch, Margaretu Univ Calif San Francisco, San Francisco, CA 94143 USA.4 aut |
700 | 1 | a Yeager, Meredithu NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.;NCI, Core Genotyping Facil, SAIC Frederick Inc, Gaithersburg, MD USA.4 aut |
700 | 1 | a Ahlbom, Andersu Karolinska Institutet4 aut |
700 | 1 | a Albanes, Demetriusu NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut |
700 | 1 | a Andersson, Ulrikau Umeå universitet,Onkologi,Umea Univ, Dept Radiat Sci, Umea, Sweden.4 aut0 (Swepub:umu)ulan0002 |
700 | 1 | a Freeman, Laura E. Beaneu NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut |
700 | 1 | a Buring, Julie E.u Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA USA.4 aut |
700 | 1 | a Butler, Mary Annu Ctr Dis Control & Prevent, Natl Inst Occupat Safety & Hlth, Cincinnati, OH USA.4 aut |
700 | 1 | a Braganza, Melissau NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut |
700 | 1 | a Carreon, Taniau Ctr Dis Control & Prevent, Natl Inst Occupat Safety & Hlth, Cincinnati, OH USA.4 aut |
700 | 1 | a Feychting, Mariau Karolinska Institutet4 aut |
700 | 1 | a Fleming, Sarah J.u Univ Leeds, Div Biostat, Leeds, W Yorkshire, England.4 aut |
700 | 1 | a Gapstur, Susan M.u Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.4 aut |
700 | 1 | a Gaziano, J. Michaelu Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA USA.;VA Boston Healthcare Syst, Massachusetts Vet Epidemiol, Res & Informat Ctr, Geriatr Res Educ & Clin Ctr, Boston, MA USA.4 aut |
700 | 1 | a Giles, Graham G.u Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia.4 aut |
700 | 1 | a Hallmans, Göranu Umeå universitet,Näringsforskning,Umea Univ, Dept Publ Hlth & Clin Med Nutr Res, Umea, Sweden.4 aut0 (Swepub:umu)goha0001 |
700 | 1 | a Henriksson, Rogeru Umeå universitet,Onkologi,Umea Univ, Dept Radiat Sci, Umea, Sweden.4 aut0 (Swepub:umu)rohe0003 |
700 | 1 | a Hoffman-Bolton, Judithu Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.4 aut |
700 | 1 | a Inskip, Peter D.u NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut |
700 | 1 | a Johansen, Christofferu Danish Canc Soc, Res Ctr, Unit Survivorship, Copenhagen, Denmark.4 aut |
700 | 1 | a Kitahara, Cari M.u NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut |
700 | 1 | a Lathrop, Marku IG CEA, Ctr Natl Genotypage, Evry, France.;Fdn Jean Dauset CEPH, Paris, France.4 aut |
700 | 1 | a Liu, Chenweiu NCI, Core Genotyping Facil, SAIC Frederick Inc, Gaithersburg, MD USA.4 aut |
700 | 1 | a Le Marchand, Loicu Univ Hawaii, Canc Res Ctr, Honolulu, HI 96822 USA.4 aut |
700 | 1 | a Linet, Martha S.u NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut |
700 | 1 | a Lonn, Stefanu Karolinska Institutet4 aut |
700 | 1 | a Peters, Ulrikeu Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.4 aut |
700 | 1 | a Purdue, Mark P.u NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut |
700 | 1 | a Rothman, Nathanielu NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut |
700 | 1 | a Ruder, Avima M.u Ctr Dis Control & Prevent, Natl Inst Occupat Safety & Hlth, Cincinnati, OH USA.4 aut |
700 | 1 | a Sanson, Marcu APHP, GH Pitie Salpetriere, Serv Neurol Mazarin, Paris, France.;CRICM, UMR INSERM UPMC 975, Paris, France.4 aut |
700 | 1 | a Sesso, Howard D.u Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA USA.4 aut |
700 | 1 | a Severi, Gianlucau Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia.4 aut |
700 | 1 | a Shu, Xiao-Ouu Vanderbilt Univ, Med Ctr, Nashville, TN USA.4 aut |
700 | 1 | a Simon, Matthiasu Neurochirurg Univklin, Bonn, Germany.4 aut |
700 | 1 | a Stampfer, Meiru Harvard Univ, Sch Med, Channing Lab, Brigham & Womens Hosp, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.4 aut |
700 | 1 | a Stevens, Victoria L.u Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.4 aut |
700 | 1 | a Visvanathan, Kalau Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.;Johns Hopkins Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA.4 aut |
700 | 1 | a White, Emilyu Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.4 aut |
700 | 1 | a Wolk, Alicjau Karolinska Inst, Inst Environm Med, Div Nutr Epidemiol, S-10401 Stockholm, Sweden.4 aut |
700 | 1 | a Zeleniuch-Jacquotte, Anneu NYU, Sch Med, Div Epidemiol, Dept Environm Med, New York, NY USA.4 aut |
700 | 1 | a Zheng, Weiu Vanderbilt Univ, Med Ctr, Nashville, TN USA.4 aut |
700 | 1 | a Decker, Paulu Mayo Clin, Rochester, MN USA.4 aut |
700 | 1 | a Enciso-Mora, Victoru Inst Canc Res, Div Genet & Epidemiol, Sutton, Surrey, England.4 aut |
700 | 1 | a Fridley, Brookeu Mayo Clin, Rochester, MN USA.4 aut |
700 | 1 | a Gao, Yu-Tangu Shanghai Jiao Tong Univ, Sch Med, Shanghai Canc Inst, Dept Epidemiol,Renji Hosp, Shanghai 200030, Peoples R China.4 aut |
700 | 1 | a Kosel, Matthewu Mayo Clin, Rochester, MN USA.4 aut |
700 | 1 | a Lachance, Daniel H.u Mayo Clin, Rochester, MN USA.4 aut |
700 | 1 | a Lau, Chingu Baylor Coll Med, Houston, TX 77030 USA.4 aut |
700 | 1 | a Rice, Terriu Univ Calif San Francisco, San Francisco, CA 94143 USA.4 aut |
700 | 1 | a Swerdlow, Anthonyu Inst Canc Res, Div Genet & Epidemiol, Sutton, Surrey, England.;Inst Canc Res, Div Breast Canc Res, London SW3 6JB, England.4 aut |
700 | 1 | a Wiemels, Joseph L.u Univ Calif San Francisco, San Francisco, CA 94143 USA.4 aut |
700 | 1 | a Wiencke, John K.u Univ Calif San Francisco, San Francisco, CA 94143 USA.4 aut |
700 | 1 | a Shete, Sanjayu Univ Texas MD Anderson Canc Ctr, Dept Biostat, Orlando, TX USA.4 aut |
700 | 1 | a Xiang, Yong-Bingu Shanghai Jiao Tong Univ, Sch Med, Shanghai Canc Inst, Dept Epidemiol,Renji Hosp, Shanghai 200030, Peoples R China.4 aut |
700 | 1 | a Xiao, Yuanyuanu Univ Calif San Francisco, San Francisco, CA 94143 USA.4 aut |
700 | 1 | a Hoover, Robert N.4 aut |
700 | 1 | a Fraumeni, Joseph F., Jr.4 aut |
700 | 1 | a Chatterjee, Nilanjan4 aut |
700 | 1 | a Hartge, Patriciau NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut |
700 | 1 | a Chanock, Stephen J.u NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.;NCI, Core Genotyping Facil, SAIC Frederick Inc, Gaithersburg, MD USA.4 aut |
710 | 2 | a NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,DHHS, Bethesda, MD 20892 USA.;NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.b Onkologi4 org |
773 | 0 | t Human Geneticsd : SPRINGERg 131:12, s. 1877-1888q 131:12<1877-1888x 0340-6717x 1432-1203 |
856 | 4 | u https://europepmc.org/articles/pmc3761216?pdf=render |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-422339 |
856 | 4 8 | u https://doi.org/10.1007/s00439-012-1212-0 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-60172 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:125557180 |
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