Dental pulp capping: effect of Emdogain Gel on experimentally exposed human pulps

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Fältnamn	Indikatorer	Metadata
000		04964naa a2200541 4500
001		oai:DiVA.org:mau-15846
003		SwePub
008		200330s2005 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:09e5a5d9-fe80-4803-8ac7-69bbf18715c1
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-158462 URI
024	7	a https://doi.org/10.1111/j.1365-2591.2004.00932.x2 DOI
024	7	a https://lup.lub.lu.se/record/1352332 URI
040		a (SwePub)maud (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Olsson, Helenau Malmö högskola,Odontologiska fakulteten (OD)4 aut0 (Swepub:mau)odheol
245	1 0	a Dental pulp capping :b effect of Emdogain Gel on experimentally exposed human pulps
264	1	b John Wiley & Sons,c 2005
338		a print2 rdacarrier
520		a AIM: To investigate the effect of Emdogain Gel (Biora AB, Malmo, Sweden), consisting of a enamel matrix derivative (EMD) in a propylene glycol alginate (PGA) vehicle, on experimentally exposed human pulps and to register postoperative symptoms. METHODOLOGY: Nine pairs of contralateral premolars scheduled for extraction on orthodontic indications were included. Following a superficial pulp amputation performed with a small (016) diamond bur, either EMDgel or a mix of calcium hydroxide and sterile saline was placed at random in contact with the pulp wound. The subjects made records of symptoms and were also interviewed about pain/discomfort by a blinded examiner. After 12 weeks the teeth were extracted, prepared and subjected to light microscopic examination in which the inflammation and newly formed hard tissue in the pulp were analysed. Immunohistochemistry was performed using affinity-purified rabbit anti-EMD polyclonal antibodies. RESULTS: Postoperative symptoms were less frequent in the EMDgel-treated than in the calcium hydroxide-treated teeth, especially during the first six weeks. In the EMDgel-treated teeth, new tissue partly filled the space initially occupied by the gel and hard tissue was formed alongside the exposed dentine surfaces and in patches in the adjacent pulp tissue. EMD was detected in the areas where new hard tissue had been formed. The wound area of the EMDgel-treated teeth exhibited inflammation in the majority of the teeth whereas less inflammation was seen in the calcium hydroxide-treated teeth where the hard tissue was formed as a bridge. CONCLUSIONS: In the EMDgel-treated teeth, postoperative symptoms were less frequent and the amount and pattern of hard tissue formation were markedly different than in the teeth treated with calcium hydroxide. However, the operative procedure and the formulation with EMD in a PGA vehicle do not seem to be effective for the formation of a hard tissue barrier.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Odontologi0 (SwePub)302162 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dentistry0 (SwePub)302162 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskap0 (SwePub)3032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciences0 (SwePub)3032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaper0 (SwePub)3012 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicine0 (SwePub)3012 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Annan klinisk medicin0 (SwePub)302992 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Other Clinical Medicine0 (SwePub)302992 hsv//eng
653		a randomized controlled trial
653		a calcium hydroxide
653		a dental pulp exposure
653		a dentinogenesis
653		a histology
653		a immunohistochemistry
700	1	a Davies, Juliau Malmö högskola,Odontologiska fakulteten (OD)4 aut0 (Swepub:mau)odjuda
700	1	a Holst, KE4 aut
700	1	a Schröder, Ullau Malmö högskola,Odontologiska fakulteten (OD)4 aut
700	1	a Petersson, Kerstinu Malmö högskola,Odontologiska fakulteten (OD)4 aut0 (Swepub:mau)odkepe
700	1	a Lindkvist, Karinu Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine4 aut0 (Swepub:lu)mbfy-kpe
710	2	a Malmö högskolab Odontologiska fakulteten (OD)4 org
773	0	t International Endodontic Journald : John Wiley & Sonsg 38:3, s. 186-194q 38:3<186-194x 0143-2885x 1365-2591
856	4	u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15743422&dopt=Abstracty FULLTEXT
856	4	u http://dx.doi.org/10.1111/j.1365-2591.2004.00932.xy FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-15846
856	4 8	u https://doi.org/10.1111/j.1365-2591.2004.00932.x
856	4 8	u https://lup.lub.lu.se/record/135233

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Av författaren/redakt...: Olsson, Helena; Davies, Julia; Holst, KE; Schröder, Ulla; Petersson, Kerst ...; Lindkvist, Karin

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Odontologi

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Annan klinisk me ...

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Av lärosätet: Malmö universitet; Lunds universitet

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