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Alcohol intake in r...
Alcohol intake in relation to non-fatal and fatal coronary heart disease and stroke : EPIC-CVD case-cohort study
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- Ricci, Cristian (författare)
- Nutritional Methodology and Biostatistics Group, International Agency for Research on Cancer, World Health Organization, 150 cours Albert Thomas, 69372 Lyon CEDEX 08, France; Centre of Excellence for Nutrition, North-West University, Potchefstroom, South Africa
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- Wood, Angela (författare)
- Medical Research Council, British Heart Foundation, Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
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- Muller, David (författare)
- Department Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
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- Gunter, Marc J. (författare)
- Nutritional Epidemiology Group, Nutrition and Metabolism Section, International Agency for Research on Cancer, Lyon, France,International Agency for Research on Cancer, World Health Organization
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- Agudo, Antonio (författare)
- Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology, Barcelona, Spain,Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment, Bilthoven, Netherlands,National Institute for Public Health and the Environment (RIVM)
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- Boeing, Heiner (författare)
- Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany
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- van der Schouw, Yvonne T. (författare)
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
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- Warnakula, Samantha (författare)
- Medical Research Council, British Heart Foundation, Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
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- Saieva, Calogero (författare)
- Cancer Risk Factors and Lifestyle Epidemiology Unit, Cancer Research and Prevention Institute, Florence, Italy,Cancer Research and Prevention Institute (ISPO)
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- Spijkerman, Annemieke (författare)
- Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment, Bilthoven, Netherlands,National Institute for Public Health and the Environment (RIVM)
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- Sluijs, Ivonne (författare)
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
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- Tjonneland, Anne (författare)
- Danish Cancer Society Research Center, Copenhagen, Denmark
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- Kyro, Cecilie (författare)
- Danish Cancer Society Research Center, Copenhagen, Denmark
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- Weiderpass, Elisabete (författare)
- Karolinska Institutet,UiT The Arctic University of Norway, Tromsø,University of Helsinki
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- Kuehn, Tilman (författare)
- Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
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- Kaaks, Rudolf (författare)
- Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
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- Sanchez, Maria-Jose (författare)
- Andaluzian School of Public Health, University of Granada, Granada, Spain; Biomedical Research Networking Center for Epidemiology and Public Health (CIBERESP), Madrid, Spain
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- Panico, Salvatore (författare)
- Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy
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- Agnoli, Claudia (författare)
- Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
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- Palli, Domenico (författare)
- Karolinska Institute,Cancer Research and Prevention Institute (ISPO)
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- Tumino, Rosario (författare)
- Cancer Registry and Histopathology Department, Civic M P Arezzo Hospital, Ragusa, Italy
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- Engström, Gunnar (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Melander, Olle (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Bonnet, Fabrice (författare)
- Rennes University Hospital, Rennes, France
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Boer, Jolanda M. A. (författare)
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- Key, Timothy J. (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
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- Travis, Ruth C. (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
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- Overvad, Kim (författare)
- Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark; Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark
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- Verschuren, W. M. Monique (författare)
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands; Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment, Bilthoven, Netherlands,National Institute for Public Health and the Environment (RIVM)
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- Quiros, J. Ramon (författare)
- Public Health Directorate of Asturias, Oviedo, Spain
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- Trichopoulou, Antonia (författare)
- Hellenic Health Foundation, Athens, Greece; WHO Collaborating Centre for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, University of Athens Medical School, Athens, Greece,National and Kapodistrian University of Athens
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- Papatesta, Eleni-Maria (författare)
- WHO Collaborating Centre for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, University of Athens Medical School, Athens, Greece,National and Kapodistrian University of Athens
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- Peppa, Eleni (författare)
- Hellenic Health Foundation, Athens, Greece
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- Iribas, Conchi Moreno (författare)
- Navarre Public Health Institute, Institute for Health Research (IdiSNA), Pamplona, Spain; Research Network in Health Services in Chronic Diseases (REDISSEC), Pamplona, Spain
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- Gavrila, Diana (författare)
- Biomedical Research Networking Center for Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain
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- Forslund, Ann-Sofie (författare)
- Umeå University,Umeå universitet,Avdelningen för medicin,Department of Public Health and Clinical Medicine, Sunderby Research Unit, Umeå University, Umeå, Sweden
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- Jansson, Jan-Håkan (författare)
- Umeå University,Umeå universitet,Avdelningen för medicin,Department of Public Health and Clinical Medicine, Skellefteå Research Unit, Department of Medicine, Umeå University, Umeå, Sweden
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- Matullo, Giuseppe (författare)
- Department Medical Sciences, University of Torino, Italian Institute for Genomic Medicine -IIGM/HuGeF, Torino, Italy
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- Arriola, Larraitz (författare)
- Public Health Division of Gipuzkoa, Instituto BIO-Donostia, Basque Government, Gipuzkoa, Spain,Biodonostia Health Research Institute
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- Freisling, Heinz (författare)
- Nutritional Methodology and Biostatistics Group, International Agency for Research on Cancer, World Health Organization, 150 cours Albert Thomas, 69372 Lyon CEDEX 08, France
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- Lassale, Camille (författare)
- Department Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK; Department of Epidemiology and Public Health, University College London, London, UK
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- Tzoulaki, Ioanna (författare)
- Department Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece
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- Sharp, Stephen J. (författare)
- Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK
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- Forouhi, Nita G. (författare)
- Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK
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- Langenberg, Claudia (författare)
- Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK
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- Saracci, Rodolfo (författare)
- Nutritional Methodology and Biostatistics Group, International Agency for Research on Cancer, World Health Organization, 150 cours Albert Thomas, 69372 Lyon CEDEX 08, France
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- Sweeting, Michael (författare)
- Medical Research Council, British Heart Foundation, Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
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- Brennan, Paul (författare)
- Genetic Epidemiology Group, Genetics Section, International Agency for Research on Cancer, Lyon, France,International Agency for Research on Cancer, World Health Organization
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- Butterworth, Adam S. (författare)
- Medical Research Council, British Heart Foundation, Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
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- Riboli, Elio (författare)
- Department Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
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Wareham, Nick J. (författare)
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- Danesh, John (författare)
- Medical Research Council, British Heart Foundation, Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
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- Ferrari, Pietro (författare)
- Nutritional Methodology and Biostatistics Group, International Agency for Research on Cancer, World Health Organization, 150 cours Albert Thomas, 69372 Lyon CEDEX 08, France
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(creator_code:org_t)
- 2018-05-29
- 2018
- Engelska.
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Ingår i: The BMJ. - : BMJ PUBLISHING GROUP. - 1756-1833 .- 0959-8138. ; 361
- Relaterad länk:
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https://umu.diva-por... (primary) (Raw object)
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https://www.bmj.com/...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- OBJECTIVE To investigate the association between alcohol consumption (at baseline and over lifetime) and non-fatal and fatal coronary heart disease (CHD) and stroke. DESIGN Multicentre case-cohort study. SETTING A study of cardiovascular disease (CVD) determinants within the European Prospective Investigation into Cancer and nutrition cohort (EPIC-CVD) from eight European countries. PARTICIPANTS 32 549 participants without baseline CVD, comprised of incident CVD cases and a subcohort for comparison. MAIN OUTCOME MEASURES Non-fatal and fatal CHD and stroke (including ischaemic and haemorrhagic stroke). RESULTS There were 9307 non-fatal CHD events, 1699 fatal CHD, 5855 non-fatal stroke, and 733 fatal stroke. Baseline alcohol intake was inversely associated with non-fatal CHD, with a hazard ratio of 0.94 (95% confidence interval 0.92 to 0.96) per 12 g/day higher intake. There was a J shaped association between baseline alcohol intake and risk of fatal CHD. The hazard ratios were 0.83 (0.70 to 0.98), 0.65 (0.53 to 0.81), and 0.82 (0.65 to 1.03) for categories 5.0-14.9 g/day, 15.0-29.9 g/day, and 30.0-59.9 g/day of total alcohol intake, respectively, compared with 0.1-4.9 g/ day. In contrast, hazard ratios for non-fatal and fatal stroke risk were 1.04 (1.02 to 1.07), and 1.05 (0.98 to 1.13) per 12 g/day increase in baseline alcohol intake, respectively, including broadly similar findings for ischaemic and haemorrhagic stroke. Associations with cardiovascular outcomes were broadly similar with average lifetime alcohol consumption as for baseline alcohol intake, and across the eight countries studied. There was no strong evidence for interactions of alcohol consumption with smoking status on the risk of CVD events. CONCLUSIONS Alcohol intake was inversely associated with non-fatal CHD risk but positively associated with the risk of different stroke subtypes. This highlights the opposing associations of alcohol intake with different CVD types and strengthens the evidence for policies to reduce alcohol consumption.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
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Ricci, Cristian
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Wood, Angela
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Muller, David
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Gunter, Marc J.
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Agudo, Antonio
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Boeing, Heiner
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van der Schouw, ...
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Warnakula, Saman ...
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Saieva, Calogero
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Spijkerman, Anne ...
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Sluijs, Ivonne
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Tjonneland, Anne
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Kyro, Cecilie
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Weiderpass, Elis ...
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Kuehn, Tilman
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Kaaks, Rudolf
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Sanchez, Maria-J ...
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Panico, Salvator ...
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Agnoli, Claudia
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Palli, Domenico
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Tumino, Rosario
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Engström, Gunnar
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Melander, Olle
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Bonnet, Fabrice
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Boer, Jolanda M. ...
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Key, Timothy J.
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Travis, Ruth C.
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Overvad, Kim
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Verschuren, W. M ...
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Quiros, J. Ramon
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Trichopoulou, An ...
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Papatesta, Eleni ...
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Peppa, Eleni
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Iribas, Conchi M ...
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Gavrila, Diana
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Forslund, Ann-So ...
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Jansson, Jan-Håk ...
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Matullo, Giusepp ...
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Arriola, Larrait ...
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Freisling, Heinz
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Lassale, Camille
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Tzoulaki, Ioanna
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Sharp, Stephen J ...
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Forouhi, Nita G.
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Langenberg, Clau ...
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Saracci, Rodolfo
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Sweeting, Michae ...
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Brennan, Paul
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Butterworth, Ada ...
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Riboli, Elio
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Wareham, Nick J.
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Danesh, John
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Ferrari, Pietro
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Arbetsmedicin oc ...
- Artiklar i publikationen
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The BMJ
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BMJ
- Av lärosätet
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Umeå universitet
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Luleå tekniska universitet
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Karolinska Institutet
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Lunds universitet