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Sex differences in the prognostic role of achieving target doses of heart failure medications: Data from the Swedish Heart Failure Registry
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- Ferrari, Amerigo (författare)
- Karolinska Inst, Sweden; St Anna Sch Adv Studies, Italy
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- Stolfo, Davide (författare)
- Karolinska Inst, Sweden; Azienda Sanit Univ Integrata Trieste, Italy
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- Uijl, Alicia (författare)
- Karolinska Inst, Sweden; Amsterdam Univ Med Ctr, Netherlands
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- Orsini, Nicola (författare)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Benson, Lina (författare)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Sinagra, Gianfranco (författare)
- Azienda Sanit Univ Integrata Trieste, Italy
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- Mol, Peter (författare)
- Univ Med Ctr Groningen, Netherlands
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- de Vries, Sieta T. (författare)
- Univ Med Ctr Groningen, Netherlands
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- Dahlström, Ulf (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Rosano, Giuseppe (författare)
- IRCCS San Raffaele, Italy; St Georges Univ London, England
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- Lund, Lars H. (författare)
- Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Savarese, Gianluigi (författare)
- Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden; Karolinska Univ Hosp, Sweden
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: European Journal of Heart Failure. - : WILEY. - 1388-9842 .- 1879-0844.
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Aims Guidelines recommend target doses (TD) of heart failure (HF) with reduced ejection fraction (HFrEF) medications regardless of sex. Differences in pharmacokinetics and pharmacodynamics may explain heterogeneity in treatment response, adverse reactions, and tolerability issues across sexes. The aim of this study was to explore sex-based differences in the association between TD achievement and mortality/morbidity in HFrEF. Methods and results Patients with HFrEF and HF duration >= 6 months registered in the Swedish HF Registry between May 2000 and December 2020 (follow-up until December 2021) were analysed. Treatments of interest were renin-angiotensin system inhibitors (RASI) or angiotensin receptor-neprilysin inhibitors (ARNI), and beta-blockers. Multivariable Cox regression models were performed to explore the risk of cardiovascular mortality or hospitalization for HF across dose categories in females versus males. A total of 17 912 patients were analysed (median age 77.0 years, interquartile range [IQR] 70.0-83.0), 29% were female. Over a median follow-up of 1.33 years (IQR 0.29-3.22), for RASI/ARNI there was no significant difference in outcome for females achieving 50-99% versus 100% of TD (hazard ratio 0.92, 95% confidence interval 0.83-1.03), whereas males showed a gradual lowering in risk together with the achievement of higher % of TD (p-interaction = 0.030). For beta-blockers the achievement of TD was associated with the lowest risk of outcome regardless of sex. Conclusions Our findings suggest that females and males might differently benefit from the same dose of RASI/ARNI, and do represent a general call for randomized controlled trials to consider sex-specific up-titration schemes when testing HFrEF treatments in need of up-titration.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Heart failure with reduced ejection fraction; Treatment; Sex; Renin-angiotensin system inhibitors; Beta-blocker; SwedeHF
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Ferrari, Amerigo
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Stolfo, Davide
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Uijl, Alicia
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Orsini, Nicola
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Benson, Lina
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Sinagra, Gianfra ...
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Mol, Peter
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de Vries, Sieta ...
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Dahlström, Ulf
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Rosano, Giuseppe
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Lund, Lars H.
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Savarese, Gianlu ...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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och Kardiologi
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Linköpings universitet
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