Sökning: L773:0179 1958 OR L773:1432 1262
> (2010-2014) >
Downregulation of m...
Downregulation of microRNA-124 is an independent prognostic factor in patients with colorectal cancer
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- Wang, Mo-Jin (författare)
- Sichuan University, China
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- Li, Yuan (författare)
- Sichuan University, China
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- Wang, Rui (författare)
- Sichuan University, China
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- Wang, Cun (författare)
- Sichuan University, China
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- Yu, Yong-Yang (författare)
- Sichuan University, China
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- Yang, Lie (författare)
- Sichuan University, China
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- Zhang, Yi (författare)
- Sichuan University, China
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- Zhou, Bin (författare)
- Sichuan University, China
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- Zhou, Zong-Guang (författare)
- Sichuan University, China
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- Sun, Xiao-Feng (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US
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(creator_code:org_t)
- 2012-08-11
- 2013
- Engelska.
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Ingår i: International Journal of Colorectal Disease. - : Springer Verlag (Germany). - 0179-1958 .- 1432-1262. ; 28:2, s. 183-189
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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http://liu.diva-port...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- PurposeRecently, microRNA-124 (miR-124) has been demonstrated as a potential tumor suppressor in several types of cancers. However, the role of miR-124 in colorectal cancer remains unclear. This study was aimed at investigating the clinicopathological significance of miR-124 expression in colorectal cancer.MethodsQuantitative real-time PCR was used to analyze miR-124 expression in 96 colorectal cancers and individual-matched normal mucosa samples. The expression of miR-124 was assessed for associations with clinicopathological characteristics using chi-square test. The survival curves were calculated by the Kaplan–Meier method. The influence of each variable on survival was examined by the Cox multivariate regression analysis.ResultsThe miR-124 expression was significantly downregulated in colorectal cancer compared to normal mucosa (P = 0.001). In colorectal cancer, miR-124 decreased expression correlated significantly with the grade of differentiation (P = 0.021). Univariate survival analysis showed that the downregulated miR-124 was significantly correlated with worse prognosis, both in terms of overall survival (P = 0.017) and disease-free survival (DFS) (P = 0.014). Further, the downregulated miR-124 was demonstrated as a prognostic factor for overall survival (hazard ratio, HR = 4.634; 95 % confidence interval, CI, 1.731–12.404; P = 0.002) and DFS (HR = 4.533, 95 % CI 1.733–11.856, P = 0.002), independently of gender, age, location, maximum tumor size, depth of invasion, differentiation, and TNM stage.ConclusionsMiR-124 may play a certain role in the development of colorectal cancer. The downregulation expression of miR-124 is an independent prognostic factor in patients with colorectal cancer.
Nyckelord
- MicroRNA-124
- Colorectal cancer
- Quantitative real-time PCR
- Survival
- MEDICINE
- MEDICIN
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- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Wang, Mo-Jin
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Li, Yuan
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Wang, Rui
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Wang, Cun
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Yu, Yong-Yang
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Yang, Lie
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visa fler...
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Zhang, Yi
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Zhou, Bin
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Zhou, Zong-Guang
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Sun, Xiao-Feng
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visa färre...
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Linköpings universitet