(WFRF:(Ahlbom Anders)) srt2:(2005-2009) pers:(Swerdlow Anthony)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04406naa a2200709 4500 | |
| 001 | oai:DiVA.org:umu-9063 | |
| 003 | SwePub | |
| 008 | 080228s2008 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:116733740 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-90632 URI |
| 024 | 7 | a https://doi.org/10.1093/jnci/djn0042 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1167337402 URI |
| 040 | a (SwePub)umud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Bethke, Lara4 aut |
| 245 | 1 0 | a Comprehensive analysis of DNA repair gene variants and risk of meningioma |
| 264 | c 2008-02-20 | |
| 264 | 1 | b Oxford University Press,c 2008 |
| 338 | a print2 rdacarrier | |
| 520 | a Background: Meningiomas account for up to 37% of all primary brain tumors. Genetic susceptibility to meningioma is well established, with the risk among relatives of meningioma patients being approximately threefold higher than that in the general population. A relationship between risk of meningioma and exposure to ionizing radiation is also well known and led us to examine whether variants in DNA repair genes contribute to disease susceptibility.Methods: We analyzed 1127 tagging single-nucleotide polymorphisms (SNPs) that were selected to capture most of the common variation in 136 DNA repair genes in five case–control series (631 case patients and 637 control subjects) from four countries in Europe. We also analyzed 388 putative functional SNPs in these genes for their association with meningioma. All statistical tests were two-sided.Results: The SNP rs4968451, which maps to intron 4 of the gene that encodes breast cancer susceptibility gene 1–interacting protein 1, was consistently associated with an increased risk of developing meningioma. Across the five studies, the association was highly statistically significant (trend odds ratio = 1.57, 95% confidence interval = 1.28 to 1.93; Ptrend = 8.95 × 10−6; P = .009 after adjusting for multiple testing).Conclusions: We have identified a novel association between rs4968451 and meningioma risk. Because approximately 28% of the European population are carriers of at-risk genotypes for rs4968451, the variant is likely to make a substantial contribution to the development of meningioma. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a genes | |
| 653 | a genetic predisposition to disease | |
| 653 | a genotype | |
| 653 | a introns | |
| 653 | a meningioma | |
| 653 | a single nucleotide polymorphism radiation | |
| 653 | a ionizing | |
| 653 | a breast cancer | |
| 653 | a primary brain tumors | |
| 653 | a dna repair gene | |
| 700 | 1 | a Murray, Anne4 aut |
| 700 | 1 | a Webb, Emily4 aut |
| 700 | 1 | a Schoemaker, Minouk4 aut |
| 700 | 1 | a Muir, Kenneth4 aut |
| 700 | 1 | a McKinney, Patricia4 aut |
| 700 | 1 | a Hepworth, Sarah4 aut |
| 700 | 1 | a Dimitropoulou, Polyxeni4 aut |
| 700 | 1 | a Lophatananon, Artitaya4 aut |
| 700 | 1 | a Feychting, Mariau Karolinska Institutet4 aut |
| 700 | 1 | a Lönn, Stefanu Karolinska Institutet4 aut |
| 700 | 1 | a Ahlbom, Andersu Karolinska Institutet4 aut |
| 700 | 1 | a Malmer, Beatriceu Umeå universitet,Onkologi4 aut0 (Swepub:umu)bema0010 |
| 700 | 1 | a Henriksson, Rogeru Umeå universitet,Onkologi4 aut0 (Swepub:umu)rohe0003 |
| 700 | 1 | a Auvinen, Anssi4 aut |
| 700 | 1 | a Kiuru, Anne4 aut |
| 700 | 1 | a Salminen, Tiina4 aut |
| 700 | 1 | a Johansen, Christoffer4 aut |
| 700 | 1 | a Collatz Christensen, Helle4 aut |
| 700 | 1 | a Kosteljanetz, Michael4 aut |
| 700 | 1 | a Swerdlow, Anthony4 aut |
| 700 | 1 | a Houlston, Richard4 aut |
| 710 | 2 | a Karolinska Institutetb Onkologi4 org |
| 773 | 0 | t Journal of the National Cancer Instituted : Oxford University Pressg 100:4, s. 270-276q 100:4<270-276x 0027-8874x 1460-2105 |
| 856 | 4 | u https://academic.oup.com/jnci/article-pdf/100/4/270/17309949/djn004.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-9063 |
| 856 | 4 8 | u https://doi.org/10.1093/jnci/djn004 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:116733740 |
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