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Interactions betwee...
Interactions between genome-wide significant genetic variants and circulating concentrations of 25-Hydroxyvitamin D in relation to prostate cancer risk in the National Cancer Institute BPC3
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- Dimitrakopoulou, Vasiliki I. (författare)
- Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Stavros Niarchos Avenue, Ioannina, Greece
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- Travis, Ruth C. (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Shui, Irene M. (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Mondul, Alison (författare)
- Department of Epidemiology, School of Public Health, University of Michigan, MI, Ann Arbor, United States
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- Albanes, Demetrius (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
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- Virtamo, Jarmo (författare)
- Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
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- Agudo, Antonio (författare)
- Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICOIDIBELL), Barcelona, Spain
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- Boeing, Heiner (författare)
- Department of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbrücke, Germany
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- Bueno-De-Mesquita, H. Bas (författare)
- Department for Determinants of Chronic Diseases, National Institute for Public Health and the Environment, Bilthoven, Netherlands; Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, Netherlands; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
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- Gunter, Marc J. (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Johansson, Mattias (författare)
- Umeå universitet,Enheten för biobanksforskning,Genetic Epidemiology Group, Genetics Section, International Agency for Research on Cancer, Lyon, France
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- Khaw, Kay-Tee (författare)
- Cambridge Institute of Public Health, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
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- Overvad, Kim (författare)
- Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark
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- Palli, Domenico (författare)
- Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute, Florence, Italy
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- Trichopoulou, Antonia (författare)
- Hellenic Health Foundation, Athens, Greece; Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece
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- Giovannucci, Edward (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Department of Medicine, Harvard Medical School, MA, Boston, United States
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- Hunter, David J. (författare)
- Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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- Lindström, Sara (författare)
- Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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- Willett, Walter (författare)
- Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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- Gaziano, J. Michael (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Department of Medicine, Harvard Medical School, MA, Boston, United States; Division of Aging, Department of Medicine, Brigham and Women's Hospital, MA, Boston, United States
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- Stampfer, Meir (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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- Berg, Christine (författare)
- Early Detection Research Group, Division of Cancer Prevention, National Cancer Institute, MD, Bethesda, United States
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- Berndt, Sonja I. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
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- Black, Amanda (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
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- Hoover, Robert N. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
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- Kraft, Peter (författare)
- Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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- Key, Timothy J. (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Tsilidis, Konstantinos K. (författare)
- Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Stavros Niarchos Avenue, Ioannina, Greece; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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(creator_code:org_t)
- 2017-02-17
- 2017
- Engelska.
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Ingår i: American Journal of Epidemiology. - : Oxford University Press (OUP). - 0002-9262 .- 1476-6256. ; 185:6, s. 452-464
- Relaterad länk:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Genome-wide association studies (GWAS) have identified over 100 single nucleotide polymorphisms (SNPs) associated with prostate cancer. However, information on the mechanistic basis for some associations is limited. Recent research has been directed towards the potential association of Vitamin D concentrations and prostate cancer, but little is known about whether the aforementioned genetic associations are modified by Vitamin D. We investigated the associations of 46 GWAS-identified SNPs, circulating concentrations of 25-hydroxyVitamin D (25 (OH)D), and prostate cancer (3,811 cases, 511 of whom died from the disease, compared with 2,980 controls- from 5 cohort studies that recruited participants over several periods beginning in the 1980s). We used logistic regression models with data from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3) to evaluate interactions on the multiplicative and additive scales. After allowing for multiple testing, none of the SNPs examined was significantly associated with 25(OH)D concentration, and the SNP-prostate cancer associations did not differ by these concentrations. A statistically significant interaction was observed for each of 2 SNPs in the 8q24 region (rs620861 and rs16902094), 25(OH)D concentration, and fatal prostate cancer on both multiplicative and additive scales (P ≥ 0.001). We did not find strong evidence that associations between GWASidentified SNPs and prostate cancer are modified by circulating concentrations of 25(OH)D. The intriguing interactions between rs620861 and rs16902094, 25(OH)D concentration, and fatal prostate cancer warrant replication.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- 25-hydroxyvitamin D
- BPC3
- gene-environment interactions
- genome-wide association studies
- prostate cancer
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Dimitrakopoulou, ...
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Travis, Ruth C.
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Shui, Irene M.
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Mondul, Alison
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Albanes, Demetri ...
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Virtamo, Jarmo
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visa fler...
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Agudo, Antonio
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Boeing, Heiner
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Bueno-De-Mesquit ...
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Gunter, Marc J.
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Johansson, Matti ...
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Khaw, Kay-Tee
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Overvad, Kim
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Palli, Domenico
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Trichopoulou, An ...
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Giovannucci, Edw ...
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Hunter, David J.
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Lindström, Sara
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Willett, Walter
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Gaziano, J. Mich ...
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Stampfer, Meir
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Berg, Christine
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Berndt, Sonja I.
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Black, Amanda
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Hoover, Robert N ...
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Kraft, Peter
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Key, Timothy J.
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Tsilidis, Konsta ...
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