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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03532naa a2200337 4500 | |
| 001 | oai:lup.lub.lu.se:47c2ba35-04dd-465a-832b-ad6e0f40e6d0 | |
| 003 | SwePub | |
| 008 | 170227s2008 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/47c2ba35-04dd-465a-832b-ad6e0f40e6d02 URI |
| 024 | 7 | a https://doi.org/10.1186/1477-9560-6-162 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Malm, Karlu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)plas-kma |
| 245 | 1 0 | a Human activated protein C variants in a rat model of arterial thrombosis |
| 264 | c 2008-10-29 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2008 |
| 520 | a BACKGROUND: Activated protein C (APC) inhibits coagulation by degrading activated factor V (FVa) and factor VIII (FVIIIa), protein S (PS) functioning as a cofactor to APC.METHODS: By mutagenesis of the vitamin K-dependent Gla domain of APC, we have recently created an APC variant having enhanced anticoagulant activity due to increased affinity for negatively charged phospholipid membranes. In the present study, the potential antithrombotic effects of this APC variant, and of a variant APC that is additionally mutated in the serine protease domain, have been evaluated in a blind randomized study in a rat model of arterial thrombosis. In this model, we have previously found the combination of bovine APC and PS to be highly antithrombotic. Four treatment groups each containing 10 rats were, in a blind random fashion, given intravenous bolus injections of wild-type or mutant variants of APC (0.8 mg/kg) together with human PS (0.6 mg/kg) or human PS (0.6 mg/kg) alone. A control group with 20 animals where given vehicle only.RESULTS: A trend to increased patency rates was noted in a group receiving one of the APC variants, but it did not reach statistical significance.CONCLUSION: In conclusion, administration of human APC variants having enhanced anticoagulant efficacy together with human PS in a rat model of arterial thrombosis did not give an efficient antithrombotic effect. The lack of effect may be due to species-specific differences between the human protein C system and the rat hemostatic system. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Läkemedelskemi0 (SwePub)301032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medicinal Chemistry0 (SwePub)301032 hsv//eng |
| 653 | a Journal Article | |
| 700 | 1 | a Arnljots, Björnu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)plas-bar |
| 700 | 1 | a Dahlbäck, Björnu Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)klke-bda |
| 710 | 2 | a Kirurgib Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Thrombosis Journald : Springer Science and Business Media LLCg 6q 6x 1477-9560 |
| 856 | 4 | u http://dx.doi.org/10.1186/1477-9560-6-16x freey FULLTEXT |
| 856 | 4 | u https://doi.org/10.1186/1477-9560-6-16 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/47c2ba35-04dd-465a-832b-ad6e0f40e6d0 |
| 856 | 4 8 | u https://doi.org/10.1186/1477-9560-6-16 |
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