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Demonstration of im...
Demonstration of immunoglobulin G with affinity for dopamine in cerebrospinal fluid from psychotic patients.
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- Bergquist, Jonas (author)
- Department of Clinical Neuroscience, Section of Psychiatry and Neurochemistry, University of Göteborg
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- Bergquist, S (author)
- Department of Psychiatry and Neurochemistry, University of Lund
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- Axelsson, R (author)
- Department of Psychiatry, Sahlgren Hospital, University of Göteborg
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- Ekman, R (author)
- Department of Clinical Neuroscience, Section of Psychiatry and Neurochemistry, University of Göteborg
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(creator_code:org_t)
- 1993
- 1993
- English.
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In: Clinica Chimica Acta. - 0009-8981 .- 1873-3492. ; 217:2, s. 129-42
- Related links:
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https://urn.kb.se/re...
Abstract
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- Using an enzyme-linked immunosorbent assay, significantly raised concentrations of immunoglobulin G with affinity for the neurotransmitter dopamine were demonstrated in cerebrospinal fluid from psychotic patients. We have varied the antigen presentation in order to find a conjugate with low unspecific binding. The conjugation of dopamine to carbodiimide-activated poly-L-glutamic acid and that to activated succinimide ester of biotin are described. The use of glutaraldehyde conjugation is not recommended because of the risk of formation of tetrahydroisoquinolines. A strong correlation (r = 0.94, P < 0.001) between the results obtained with dopamine conjugated to poly-L-glutamic acid and dopamine conjugated to biotin was observed. Forty-two human cerebrospinal fluid samples from 20 psychotic patients, (12 with a bipolar disorder and 8 with schizophrenia) and 22 control patients, with various neurological diseases but no apparent psychiatric diseases were investigated. A significantly higher incidence (P < 0.001) of antibodies with affinity for dopamine were found in the group of psychotic patients compared with the neurological control group.
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