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Sökning: (WFRF:(Haberg AK)) pers:(Espeseth T) > Brain scans from 21...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05630naa a2200985 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:145820287 | |
| 003 | SwePub | |
| 008 | 240701s2020 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:umu-169597 | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1458202872 URI |
| 024 | 7 | a https://doi.org/10.1038/s41380-018-0262-72 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1695972 URI |
| 040 | a (SwePub)kid (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a van der Meer, D4 aut |
| 245 | 1 0 | a Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes |
| 264 | c 2018-10-02 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2020 |
| 520 | a The hippocampus is a heterogeneous structure, comprising histologically distinguishable subfields. These subfields are differentially involved in memory consolidation, spatial navigation and pattern separation, complex functions often impaired in individuals with brain disorders characterized by reduced hippocampal volume, including Alzheimer’s disease (AD) and schizophrenia. Given the structural and functional heterogeneity of the hippocampal formation, we sought to characterize the subfields’ genetic architecture. T1-weighted brain scans (n = 21,297, 16 cohorts) were processed with the hippocampal subfields algorithm in FreeSurfer v6.0. We ran a genome-wide association analysis on each subfield, co-varying for whole hippocampal volume. We further calculated the single-nucleotide polymorphism (SNP)-based heritability of 12 subfields, as well as their genetic correlation with each other, with other structural brain features and with AD and schizophrenia. All outcome measures were corrected for age, sex and intracranial volume. We found 15 unique genome-wide significant loci across six subfields, of which eight had not been previously linked to the hippocampus. Top SNPs were mapped to genes associated with neuronal differentiation, locomotor behaviour, schizophrenia and AD. The volumes of all the subfields were estimated to be heritable (h2 from 0.14 to 0.27, all p < 1 × 10–16) and clustered together based on their genetic correlations compared with other structural brain features. There was also evidence of genetic overlap of subicular subfield volumes with schizophrenia. We conclude that hippocampal subfields have partly distinct genetic determinants associated with specific biological processes and traits. Taking into account this specificity may increase our understanding of hippocampal neurobiology and associated pathologies. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 700 | 1 | a Rokicki, J4 aut |
| 700 | 1 | a Kaufmann, T4 aut |
| 700 | 1 | a Cordova-Palomera, A4 aut |
| 700 | 1 | a Moberget, T4 aut |
| 700 | 1 | a Alnaes, D4 aut |
| 700 | 1 | a Bettella, F4 aut |
| 700 | 1 | a Frei, O4 aut |
| 700 | 1 | a Doan, NT4 aut |
| 700 | 1 | a Sonderby, IE4 aut |
| 700 | 1 | a Smeland, OB4 aut |
| 700 | 1 | a Agartz, Iu Karolinska Institutet4 aut |
| 700 | 1 | a Bertolino, A4 aut |
| 700 | 1 | a Bralten, J4 aut |
| 700 | 1 | a Brandt, CL4 aut |
| 700 | 1 | a Buitelaar, JK4 aut |
| 700 | 1 | a Djurovic, S4 aut |
| 700 | 1 | a van Donkelaar, M4 aut |
| 700 | 1 | a Dorum, ES4 aut |
| 700 | 1 | a Espeseth, T4 aut |
| 700 | 1 | a Faraone, SV4 aut |
| 700 | 1 | a Fernandez, G4 aut |
| 700 | 1 | a Fisher, SE4 aut |
| 700 | 1 | a Franke, B4 aut |
| 700 | 1 | a Haatveit, B4 aut |
| 700 | 1 | a Hartman, CA4 aut |
| 700 | 1 | a Hoekstra, PJ4 aut |
| 700 | 1 | a Haberg, AK4 aut |
| 700 | 1 | a Jonsson, EGu Karolinska Institutet4 aut |
| 700 | 1 | a Kolskar, KK4 aut |
| 700 | 1 | a Le Hellard, S4 aut |
| 700 | 1 | a Lund, MJ4 aut |
| 700 | 1 | a Lundervold, AJ4 aut |
| 700 | 1 | a Lundervold, A4 aut |
| 700 | 1 | a Melle, I4 aut |
| 700 | 1 | a Sanchez, JM4 aut |
| 700 | 1 | a Norbom, LC4 aut |
| 700 | 1 | a Nordvik, JE4 aut |
| 700 | 1 | a Nyberg, Lars,d 1966-u Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för integrativ medicinsk biologi (IMB)4 aut0 (Swepub:umu)lany0001 |
| 700 | 1 | a Oosterlaan, J4 aut |
| 700 | 1 | a Papalino, M4 aut |
| 700 | 1 | a Papassotiropoulos, A4 aut |
| 700 | 1 | a Pergola, G4 aut |
| 700 | 1 | a de Quervain, DJF4 aut |
| 700 | 1 | a Richard, G4 aut |
| 700 | 1 | a Sanders, AM4 aut |
| 700 | 1 | a Selvaggi, P4 aut |
| 700 | 1 | a Shumskaya, E4 aut |
| 700 | 1 | a Steen, VM4 aut |
| 700 | 1 | a Tonnesen, S4 aut |
| 700 | 1 | a Ulrichsen, KM4 aut |
| 700 | 1 | a Zwiers, MP4 aut |
| 700 | 1 | a Andreassen, OA4 aut |
| 700 | 1 | a Westlye, LT4 aut |
| 710 | 2 | a Karolinska Institutetb Diagnostisk radiologi4 org |
| 773 | 0 | t Molecular psychiatryd : Springer Science and Business Media LLCg 25:11, s. 3053-3065q 25:11<3053-3065x 1476-5578x 1359-4184 |
| 856 | 4 | u https://www.nature.com/articles/s41380-018-0262-7.pdf |
| 856 | 4 | u https://doi.org/10.1038/s41380-018-0262-7y Fulltext |
| 856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1422643/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:145820287 |
| 856 | 4 8 | u https://doi.org/10.1038/s41380-018-0262-7 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169597 |
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- Brandt, CL
- Buitelaar, JK
- Djurovic, S
- van Donkelaar, M
- Dorum, ES
- Espeseth, T
- Faraone, SV
- Fernandez, G
- Fisher, SE
- Franke, B
- Haatveit, B
- Hartman, CA
- Hoekstra, PJ
- Haberg, AK
- Jonsson, EG
- Kolskar, KK
- Le Hellard, S
- Lund, MJ
- Lundervold, AJ
- Lundervold, A
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