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Sökning: (WFRF:(Heikkilä Hannele)) > Radiation-induced a...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006291naa a2200625 4500
001oai:DiVA.org:uu-428999
003SwePub
008201218s2020 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4289992 URI
0247 a https://doi.org/10.1093/nop/npaa0022 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Remes, Tiina Mariau Oulu Univ Hosp, Dept Pediat & Adolescence, PEDEGO Res Unit, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finland4 aut
2451 0a Radiation-induced accelerated aging of the brain vasculature in young adult survivors of childhood brain tumors
264 c 2020-02-07
264 1b Oxford University Press (OUP),c 2020
338 a electronic2 rdacarrier
520 a BackgroundCranial radiotherapy may damage the cerebral vasculature. The aim of this study was to understand the prevalence and risk factors of cerebrovascular disease (CVD) and white matter hyperintensities (WMHs) in childhood brain tumors (CBT) survivors treated with radiotherapy.MethodsSeventy CBT survivors who received radiotherapy were enrolled in a cross-sectional study at a median 20 years after radiotherapy cessation. The prevalence of and risk factors for CVD were investigated using MRI, MRA, and laboratory testing. Tumors, their treatment, and stroke-related data were retrieved from patients’ files.ResultsForty-four individuals (63%) had CVD at a median age of 27 years (range, 16-43 years). The prevalence rates at 20 years for CVD, small-vessel disease, and large-vessel disease were 52%, 38%, and 16%, respectively. Ischemic infarcts were diagnosed in 6 survivors, and cerebral hemorrhage in 2. Lacunar infarcts were present in 7, periventricular or deep WMHs in 34 (49%), and mineralizing microangiopathy in 21 (30%) survivors. Multiple pathologies were detected in 44% of the participants, and most lesions were located in a high-dose radiation area. Higher blood pressure was associated with CVD and a presence of WMHs. Higher cholesterol levels increased the risk of ischemic infarcts and WMHs, and lower levels of high-density lipoprotein and higher waist circumference increased the risk of lacunar infarcts.ConclusionsTreating CBTs with radiotherapy increases the risk of early CVD and WMHs in young adult survivors. These results suggest an urgent need for investigating CVD prevention in CBT patients.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653 a brain tumor
653 a cerebrovascular disease
653 a radiotherapy
653 a stroke
653 a survivor
7001 a Suo-Palosaari, Maria Helenau Univ Oulu, Res Unit Med Imaging Phys & Technol, Fac Med, Oulu, Finland; Univ Oulu, Med Res Ctr Oulu, Oulu, Finland4 aut
7001 a Koskenkorva, Päivi K. T.u Kuopio Univ Hosp, Dept Clin Radiol, Kuopio, Finland4 aut
7001 a Sutela, Anna K.u Kuopio Univ Hosp, Dept Clin Radiol, Kuopio, Finland4 aut
7001 a Toiviainen-Salo, Sanna-Mariau Univ Helsinki, HUS Med Imaging Ctr, Dept Pediat Radiol, Radiol, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland4 aut
7001 a Arikoski, Pekka M.u Univ Eastern Finland, Kuopio Univ Hosp, Dept Pediat & Adolescence, Kuopio, Finland4 aut
7001 a Arola, Mikko O.u Tampere Univ Hosp, Dept Pediat, Tampere, Finland; Univ Tampere, Tampere, Finland4 aut
7001 a Heikkilä, Vesa-Pekkau Oulu Univ Hosp, Dept Oncol & Radiotherapy, Oulu, Finland4 aut
7001 a Kapanen, Mikau Tampere Univ Hosp, Dept Oncol, Tampere, Finland; Tampere Univ Hosp, Dept Med Phys, Tampere, Finland4 aut
7001 a Lähteenmäki, Päivi Mariau Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland; Turku Univ, Turku, Finland4 aut
7001 a Lönnqvist, Tuula R. I.u Helsinki Univ Hosp, Helsinki, Finland; Univ Helsinki, Childrens Hosp, Dept Child Neurol, Helsinki, Finland4 aut
7001 a Niiniviita, Hanneleu Turku Univ Hosp, Dept Med Phys, Div Med Imaging, Turku, Finland4 aut
7001 a Pokka, Tytti M.-L.u Oulu Univ Hosp, Dept Pediat & Adolescence, PEDEGO Res Unit, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finland4 aut
7001 a Porra, Liisau Helsinki Univ Hosp, Helsinki, Finland; Univ Helsinki, Dept Oncol, Helsinki, Finland4 aut
7001 a Riikonen, V. Pekkau Univ Eastern Finland, Kuopio Univ Hosp, Dept Pediat & Adolescence, Kuopio, Finland4 aut
7001 a Seppälä, Janu Kuopio Univ Hosp, Ctr Oncol, Kuopio, Finland4 aut
7001 a Sirkiä, Kirsti H.u Helsinki Univ Hosp, Helsinki, Finland; Univ Helsinki, Dept Pediat & Adolescence, Helsinki, Finland4 aut
7001 a Vanhanen, Anttiu Tampere Univ Hosp, Dept Oncol, Tampere, Finland; Tampere Univ Hosp, Dept Med Phys, Tampere, Finland4 aut
7001 a Rantala, Heikki M. J.u Oulu Univ Hosp, Dept Pediat & Adolescence, PEDEGO Res Unit, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finland4 aut
7001 a Harila-Saari, Arja H.u Uppsala universitet,Barnneurologi/Barnonkologi4 aut0 (Swepub:uu)arjha456
7001 a Ojaniemi, Marja K.u Oulu Univ Hosp, Dept Pediat & Adolescence, PEDEGO Res Unit, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finland4 aut
7102 a Oulu Univ Hosp, Dept Pediat & Adolescence, PEDEGO Res Unit, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finlandb Univ Oulu, Res Unit Med Imaging Phys & Technol, Fac Med, Oulu, Finland; Univ Oulu, Med Res Ctr Oulu, Oulu, Finland4 org
7730 t Neuro-Oncology Practiced : Oxford University Press (OUP)g 7:4, s. 415-427q 7:4<415-427x 2054-2577x 2054-2585
8564 u https://doi.org/10.1093/nop/npaa002y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1511446/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://doi.org/10.1093/nop/npaa002
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-428999
8564 8u https://doi.org/10.1093/nop/npaa002

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