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Evidence for two in...
Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12
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Sun, Jielin (author)
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Zheng, Siqun Lilly (author)
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- Wiklund, Fredrik (author)
- Karolinska Institutet
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Isaacs, Sarah D. (author)
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Purcell, Lina D. (author)
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Gao, Zhengrong (author)
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Hsu, Fang-Chi (author)
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Kim, Seong-Tae (author)
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Liu, Wennuan (author)
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Zhu, Yi (author)
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- Stattin, Pär (author)
- Umeå universitet,Urologi och andrologi
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- Adami, Hans-Olov (author)
- Karolinska Institutet
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Wiley, Kathleen E. (author)
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Dimitrov, Latchezar (author)
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Sun, Jishan (author)
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Li, Tao (author)
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Turner, Aubrey R. (author)
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Adams, Tamara S. (author)
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- Adolfsson, Jan (author)
- Karolinska Institutet
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- Johansson, Jan-Erik (author)
- Örebro universitet,Hälsoakademin
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Lowey, James (author)
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Trock, Bruce J. (author)
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Partin, Alan W. (author)
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Walsh, Patrick C. (author)
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Trent, Jeffrey M. (author)
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Duggan, David (author)
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Carpten, John (author)
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Chang, Bao-Li (author)
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- Grönberg, Henrik (author)
- Karolinska Institutet
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Isaacs, William B. (author)
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Xu, Jianfeng (author)
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(creator_code:org_t)
- 2008-08-31
- 2008
- English.
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In: Nature Genetics. - London : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 40:10, s. 1153-1155
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https://europepmc.or...
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Abstract
Subject headings
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- We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, 26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 10-9 for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- Aged
- Chromosome Mapping
- Chromosomes; Human; Pair 17/*genetics
- Genetic Predisposition to Disease/*genetics
- Haplotypes/*genetics
- Hepatocyte Nuclear Factor 1-beta/*genetics
- Humans
- Linkage (Genetics)
- Male
- Middle Aged
- Polymorphism; Single Nucleotide/*genetics
- Prostatic Neoplasms/*genetics/pathology
- Risk Factors
- MEDICINE
- MEDICIN
- Clinical genetics
- Klinisk genetik
- Medical Genetics
- Medicinsk genetik
Publication and Content Type
- vet (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Sun, Jielin
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Zheng, Siqun Lil ...
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Wiklund, Fredrik
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Isaacs, Sarah D.
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Purcell, Lina D.
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Gao, Zhengrong
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show more...
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Hsu, Fang-Chi
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Kim, Seong-Tae
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Liu, Wennuan
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Zhu, Yi
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Stattin, Pär
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Adami, Hans-Olov
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Wiley, Kathleen ...
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Dimitrov, Latche ...
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Sun, Jishan
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Li, Tao
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Turner, Aubrey R ...
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Adams, Tamara S.
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Adolfsson, Jan
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Johansson, Jan-E ...
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Lowey, James
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Trock, Bruce J.
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Partin, Alan W.
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Walsh, Patrick C ...
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Trent, Jeffrey M ...
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Duggan, David
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Carpten, John
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Chang, Bao-Li
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Grönberg, Henrik
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Isaacs, William ...
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Xu, Jianfeng
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Nature Genetics
- By the university
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Örebro University
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Umeå University
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Karolinska Institutet