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(WFRF:(Kamble Rammurti T.)) srt2:(2020) pers:(Ganguly Siddhartha)
 

Sökning: (WFRF:(Kamble Rammurti T.)) srt2:(2020) pers:(Ganguly Siddhartha) > Weighty choices :

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007350naa a2200721 4500
001oai:DiVA.org:uu-408257
003SwePub
008200406s2020 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:143219837
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4082572 URI
0247 a https://doi.org/10.1182/bloodadvances.20190009232 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1432198372 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Farhadfar, Noshau Shands HealthCare & Univ Florida, Dept Med, Div Hematol & Oncol, Gainesville, FL USA4 aut
2451 0a Weighty choices :b selecting optimal G-CSF doses for stem cell mobilization to optimize yield
264 c 2020-02-24
264 1b AMER SOC HEMATOLOGY,c 2020
338 a print2 rdacarrier
520 a There are limited data on the effect of donor body mass index (BMI) on peripheral blood stem cell (PBSC) mobilization response to granulocyte colony-stimulating factor (G-CSF), especially in unrelated donors. Obesity has been associated with persistent leukocytosis, elevated circulating progenitor cells, and enhanced stem cell mobilization. Therefore, we hypothesized that adequate collection of CD34(+) cells may be achieved with lower doses (per kilogram of body weight) of G-CSF in donors with higher BMI compared with donors with lower BMI. Using the Center for International Blood and Marrow Transplant Research database, we evaluated the impact of donor BMI on G-CSF-mobilized PBSC yield in healthy unrelated donors. We examined 20 884 PBSC donations collected at National Marrow Donor Program centers between 2006 and 2016. We found significantly higher collection yields in obese and severely obese donors compared with normal and overweight donors. An increase in average daily G-CSF dose was associated with an increase in stem cell yield in donors with normal or overweight BMI. In contrast, an increase in average daily G-CSF dose beyond 780 mu g per day in obese and 900 mg per day in severely obese donors did not increase cell yield. Pain and toxicities were assessed at baseline, during G-CSF administration, and postcollection. Obesity was associated with higher levels of self-reported donation-related pain and toxicities in the pericollection and early postdonation recovery periods. This study suggests a maximum effective G-CSF dose for PBSC mobilization in obese and severely obese donors, beyond which higher doses of G-CSF add no increased yield.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng
7001 a Hsu, Jack W.u Shands HealthCare & Univ Florida, Dept Med, Div Hematol & Oncol, Gainesville, FL USA4 aut
7001 a Logan, Brent R.u CIBMTR, Dept Med, Milwaukee, WI 53226 USA;Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA4 aut
7001 a Sees, Jennifer A.u CIBMTR, Natl Marrow Donor Program Be Match, Minneapolis, MN USA4 aut
7001 a Chitphakdithai, Pintipu CIBMTR, Natl Marrow Donor Program Be Match, Minneapolis, MN USA4 aut
7001 a Sugrue, Michele W.u Shands HealthCare & Univ Florida, Dept Med, Div Hematol & Oncol, Gainesville, FL USA4 aut
7001 a Abdel-Azim, Hishamu Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA4 aut
7001 a Anderlini, Paolo N.u Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Houston, TX 77030 USA4 aut
7001 a Bredeson, Christopheru Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, Canada;Ottawa Hosp, Res Inst, Ottawa, ON, Canada4 aut
7001 a Chhabra, Saurabhu Med Coll Wisconsin, Dept Med, Div Hematol Oncol, Milwaukee, WI 53226 USA4 aut
7001 a Diaz, Miguel Angelu Hosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain4 aut
7001 a Ganguly, Siddharthau Univ Kansas Hlth Syst, Div Hematol Malignancy & Cellular Therapeut, Kansas City, KS USA4 aut
7001 a Hematti, Peimanu Univ Wisconsin Hosp & Clin, Dept Med, Div Hematol Oncol Bone Marrow Transplantat, Madison, WI 53792 USA4 aut
7001 a Kamble, Rammurti T.u Baylor Coll Med, Ctr Cell & Gene Therapy, Div Hematol & Oncol, Houston, TX 77030 USA4 aut
7001 a Kasow, Kimberly A.u Univ N Carolina, Pediat Hematol Oncol Program, Chapel Hill, NC 27515 USA4 aut
7001 a Lazarus, Hillard M.u Univ Hosp Cleveland, Med Ctr, Seidman Canc Ctr, Cleveland, OH 44106 USA4 aut
7001 a Lynch, Debra Kellyu Shands HealthCare & Univ Florida, Dept Med, Div Hematol & Oncol, Gainesville, FL USA4 aut
7001 a Murthy, Hemant S.u Shands HealthCare & Univ Florida, Dept Med, Div Hematol & Oncol, Gainesville, FL USA4 aut
7001 a Olsson, Richardu Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Div Therapeut Immunol, Stockholm, Sweden;4 aut0 (Swepub:uu)riols677
7001 a Papari, Monau ITxM Clin Serv Cord Blood Lab, Rosemont, IL USA4 aut
7001 a Przepiorka, Donnau US FDA, Ctr Biol Evaluat & Res, North Potomac, MD USA4 aut
7001 a Savani, Bipin N.u Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA4 aut
7001 a Schears, Raquelu Mayo Clin & Mayo Grad Sch Med, Dept Emergency Med, Rochester, MN USA4 aut
7001 a Seo, Sachikou Dokkyo Med Univ, Dept Hematol & Oncol, Mibu, Tochigi, Japan4 aut
7001 a Solh, Melhem M.u Northside Hosp, Blood & Marrow Transplant Program, Atlanta, GA USA4 aut
7001 a Spitzer, Thomasu Massachusetts Gen Hosp, Boston, MA 02114 USA4 aut
7001 a Yared, Jean A.u Univ Maryland, Dept Med, Greenebaum Canc Ctr, Blood & Marrow Transplantat Program,Div Hematol O, Baltimore, MD 21201 USA4 aut
7001 a Pulsipher, Michael A.u Childrens Hosp Los Angeles, USC Keck Sch Med, Div Hematol Blood & Marrow Transplantat, Los Angeles, CA 90027 USA4 aut
7001 a Shah, Nirali N.u NCI, Pediat Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA4 aut
7001 a Switzer, Galen E.u Univ Pittsburgh, Dept Med, Pittsburgh, PA USA4 aut
7001 a Confer, Dennis L.u CIBMTR, Natl Marrow Donor Program Be Match, Minneapolis, MN USA;Natl Marrow Donor Program Be Match, Minneapolis, MN USA4 aut
7001 a Shaw, Bronwen E.u CIBMTR, Dept Med, Milwaukee, WI 53226 USA4 aut
7001 a Wingard, John R.u Shands HealthCare & Univ Florida, Dept Med, Div Hematol & Oncol, Gainesville, FL USA4 aut
7102 a Shands HealthCare & Univ Florida, Dept Med, Div Hematol & Oncol, Gainesville, FL USAb CIBMTR, Dept Med, Milwaukee, WI 53226 USA;Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA4 org
7730 t Blood Advancesd : AMER SOC HEMATOLOGYg 4:4, s. 706-716q 4:4<706-716x 2473-9529x 2473-9537
8564 u https://ashpublications.org/bloodadvances/article-pdf/4/4/706/1717406/advancesadv2019000923.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-408257
8564 8u https://doi.org/10.1182/bloodadvances.2019000923
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:143219837

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