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Loci influencing bl...
Loci influencing blood pressure identified using a cardiovascular gene-centric array
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Ganesh, Santhi K. (author)
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Tragante, Vinicius (author)
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Guo, Wei (author)
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show more...
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Guo, Yiran (author)
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Lanktree, Matthew B. (author)
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Smith, Erin N. (author)
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Johnson, Toby (author)
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Castillo, Berta Almoguera (author)
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Barnard, John (author)
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Baumert, Jens (author)
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Chang, Yen-Pei Christy (author)
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Elbers, Clara C. (author)
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Farrall, Martin (author)
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Fischer, Mary E. (author)
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Franceschini, Nora (author)
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Gaunt, Tom R. (author)
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Gho, Johannes M. I. H. (author)
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Gieger, Christian (author)
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Gong, Yan (author)
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Isaacs, Aaron (author)
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Kleber, Marcus E. (author)
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Leach, Irene Mateo (author)
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McDonough, Caitrin W. (author)
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Meijs, Matthijs F. L. (author)
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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Molony, Cliona M. (author)
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Nolte, Ilja M. (author)
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Padmanabhan, Sandosh (author)
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Price, Tom S. (author)
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Rajagopalan, Ramakrishnan (author)
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Shaffer, Jonathan (author)
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Shah, Sonia (author)
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Shen, Haiqing (author)
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Soranzo, Nicole (author)
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van der Most, Peter J. (author)
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Van Iperen, Erik P. A. (author)
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Van Setten, Jessic A. (author)
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Vonk, Judith M. (author)
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Zhang, Li (author)
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Beitelshees, Amber L. (author)
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Berenson, Gerald S. (author)
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Bhatt, Deepak L. (author)
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Boer, Jolanda M. A. (author)
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Boerwinkle, Eric (author)
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Burkley, Ben (author)
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Burt, Amber (author)
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Chakravarti, Aravinda (author)
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Chen, Wei (author)
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Cooper-DeHoff, Rhonda M. (author)
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Curtis, Sean P. (author)
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Dreisbach, Albert (author)
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Duggan, David (author)
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Ehret, Georg B. (author)
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Fabsitz, Richard R. (author)
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Fornage, Myriam (author)
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Fox, Ervin (author)
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Furlong, Clement E. (author)
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Gansevoort, Ron T. (author)
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Hofker, Marten H. (author)
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Hovingh, G. Kees (author)
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Kirkland, Susan A. (author)
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Kottke-Marchant, Kandice (author)
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Kutlar, Abdullah (author)
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LaCroix, Andrea Z. (author)
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Langaee, Taimour Y. (author)
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Li, Yun R. (author)
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Lin, Honghuang (author)
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Liu, Kiang (author)
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Maiwald, Steffi (author)
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Malik, Rainer (author)
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Murugesan, Gurunathan (author)
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Newton-Cheh, Christopher (author)
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OConnell, Jeffery R. (author)
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Onland-Moret, N. Charlotte (author)
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Ouwehand, Willem H. (author)
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Palmas, Walter (author)
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Penninx, Brenda W. (author)
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Pepine, Carl J. (author)
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Pettinger, Mary (author)
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Polak, Joseph F. (author)
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Ramachandran, Vasan S. (author)
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Ranchalis, Jane (author)
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Redline, Susan (author)
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Ridker, Paul M. (author)
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Rose, Lynda M. (author)
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Scharnag, Hubert (author)
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Schork, Nicholas J. (author)
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Shimbo, Daichi (author)
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Shuldiner, Alan R. (author)
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Srinivasan, Sathanur R. (author)
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Stolk, Ronald P. (author)
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Taylor, Herman A. (author)
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Thorand, Barbara (author)
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Trip, Mieke D. (author)
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van Duijn, Cornelia M. (author)
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Verschuren, W. Monique (author)
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Wijmenga, Cisca (author)
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Winkelmann, Bernhard R. (author)
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Wyatt, Sharon (author)
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Young, J. Hunter (author)
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Boehm, Bernhard O. (author)
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Caulfield, Mark J. (author)
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Chasman, Daniel I. (author)
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Davidson, Karina W. (author)
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Doevendans, Pieter A. (author)
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FitzGerald, Garret A. (author)
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Gums, John G. (author)
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Hakonarson, Hakon (author)
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Hillege, Hans L. (author)
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Illig, Thomas (author)
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Jarvik, Gail P. (author)
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Johnson, Julie A. (author)
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Kastelein, John J. P. (author)
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Koenig, Wolfgang (author)
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Maerz, Winfried (author)
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Mitchell, Braxton D. (author)
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Murray, Sarah S. (author)
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Oldehinkel, Albertine J. (author)
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Rader, Daniel J. (author)
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Reilly, Muredach P. (author)
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Reiner, Alex P. (author)
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Schadt, Eric E. (author)
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Silverstein, Roy L. (author)
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Snieder, Harold (author)
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Stanton, Alice V. (author)
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Uitterlinden, Andre G. (author)
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van der Harst, Pim (author)
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van der Schouw, Yvonne T. (author)
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Samani, Nilesh J. (author)
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Johnson, Andrew D. (author)
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Munroe, Patricia B. (author)
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de Bakker, Paul I. W. (author)
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Zhu, Xiaofeng (author)
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Levy, Daniel (author)
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Keating, Brendan J. (author)
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Asselbergs, Folkert W. (author)
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(creator_code:org_t)
- 2013-01-08
- 2013
- English.
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In: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 22:8, s. 1663-1678
- Related links:
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http://dx.doi.org/10...
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https://academic.oup...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Blood pressure (BP) is a heritable determinant of risk for cardiovascular disease (CVD). To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP) and pulse pressure (PP), we genotyped 50 000 single-nucleotide polymorphisms (SNPs) that capture variation in 2100 candidate genes for cardiovascular phenotypes in 61 619 individuals of European ancestry from cohort studies in the USA and Europe. We identified novel associations between rs347591 and SBP (chromosome 3p25.3, in an intron of HRH1) and between rs2169137 and DBP (chromosome1q32.1 in an intron of MDM4) and between rs2014408 and SBP (chromosome 11p15 in an intron of SOX6), previously reported to be associated with MAP. We also confirmed 10 previously known loci associated with SBP, DBP, MAP or PP (ADRB1, ATP2B1, SH2B3/ATXN2, CSK, CYP17A1, FURIN, HFE, LSP1, MTHFR, SOX6) at array-wide significance (P 2.4 10(6)). We then replicated these associations in an independent set of 65 886 individuals of European ancestry. The findings from expression QTL (eQTL) analysis showed associations of SNPs in the MDM4 region with MDM4 expression. We did not find any evidence of association of the two novel SNPs in MDM4 and HRH1 with sequelae of high BP including coronary artery disease (CAD), left ventricular hypertrophy (LVH) or stroke. In summary, we identified two novel loci associated with BP and confirmed multiple previously reported associations. Our findings extend our understanding of genes involved in BP regulation, some of which may eventually provide new targets for therapeutic intervention.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Ganesh, Santhi K ...
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Tragante, Vinici ...
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Guo, Wei
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Guo, Yiran
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Lanktree, Matthe ...
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Smith, Erin N.
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show more...
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Johnson, Toby
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Castillo, Berta ...
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Barnard, John
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Baumert, Jens
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Chang, Yen-Pei C ...
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Elbers, Clara C.
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Farrall, Martin
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Fischer, Mary E.
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Franceschini, No ...
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Gaunt, Tom R.
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Gho, Johannes M. ...
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Gieger, Christia ...
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Gong, Yan
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Isaacs, Aaron
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Kleber, Marcus E ...
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Leach, Irene Mat ...
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McDonough, Caitr ...
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Meijs, Matthijs ...
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Melander, Olle
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Molony, Cliona M ...
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Nolte, Ilja M.
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Padmanabhan, San ...
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Price, Tom S.
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Rajagopalan, Ram ...
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Shaffer, Jonatha ...
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Shah, Sonia
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Shen, Haiqing
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Soranzo, Nicole
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van der Most, Pe ...
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Van Iperen, Erik ...
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Van Setten, Jess ...
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Vonk, Judith M.
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Zhang, Li
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Beitelshees, Amb ...
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Berenson, Gerald ...
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Bhatt, Deepak L.
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Boer, Jolanda M. ...
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Boerwinkle, Eric
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Burkley, Ben
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Burt, Amber
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Chakravarti, Ara ...
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Chen, Wei
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Cooper-DeHoff, R ...
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Curtis, Sean P.
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Dreisbach, Alber ...
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Duggan, David
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Ehret, Georg B.
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Fabsitz, Richard ...
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Fornage, Myriam
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Fox, Ervin
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Furlong, Clement ...
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Gansevoort, Ron ...
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Hofker, Marten H ...
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Hovingh, G. Kees
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Kirkland, Susan ...
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Kottke-Marchant, ...
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Kutlar, Abdullah
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LaCroix, Andrea ...
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Langaee, Taimour ...
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Li, Yun R.
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Lin, Honghuang
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Liu, Kiang
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Maiwald, Steffi
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Malik, Rainer
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Murugesan, Gurun ...
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Newton-Cheh, Chr ...
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OConnell, Jeffer ...
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Onland-Moret, N. ...
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Ouwehand, Willem ...
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Palmas, Walter
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Penninx, Brenda ...
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Pepine, Carl J.
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Pettinger, Mary
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Polak, Joseph F.
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Ramachandran, Va ...
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Ranchalis, Jane
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Redline, Susan
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Ridker, Paul M.
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Rose, Lynda M.
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Scharnag, Hubert
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Schork, Nicholas ...
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Shimbo, Daichi
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Shuldiner, Alan ...
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Srinivasan, Sath ...
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Stolk, Ronald P.
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Taylor, Herman A ...
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Thorand, Barbara
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Trip, Mieke D.
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van Duijn, Corne ...
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Verschuren, W. M ...
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Wijmenga, Cisca
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Winkelmann, Bern ...
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Wyatt, Sharon
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Young, J. Hunter
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Boehm, Bernhard ...
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Caulfield, Mark ...
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Chasman, Daniel ...
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Davidson, Karina ...
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Doevendans, Piet ...
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FitzGerald, Garr ...
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Gums, John G.
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Hakonarson, Hako ...
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Hillege, Hans L.
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Illig, Thomas
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Jarvik, Gail P.
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Johnson, Julie A ...
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Kastelein, John ...
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Koenig, Wolfgang
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Maerz, Winfried
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Mitchell, Braxto ...
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Murray, Sarah S.
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Oldehinkel, Albe ...
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Rader, Daniel J.
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Reilly, Muredach ...
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Reiner, Alex P.
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Schadt, Eric E.
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Silverstein, Roy ...
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Snieder, Harold
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Stanton, Alice V ...
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Uitterlinden, An ...
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van der Harst, P ...
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van der Schouw, ...
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Samani, Nilesh J ...
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Johnson, Andrew ...
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Munroe, Patricia ...
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de Bakker, Paul ...
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Zhu, Xiaofeng
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Levy, Daniel
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Keating, Brendan ...
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Asselbergs, Folk ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Human Molecular ...
- By the university
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Lund University