A variant in FTO shows association with melanoma risk not due to BMI

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Fältnamn	Indikatorer	Metadata
000		06643naa a2201429 4500
001		oai:lup.lub.lu.se:fe22906b-6821-4428-99a8-851310dde0be
003		SwePub
008		160401s2013 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:126492457
024	7	a https://lup.lub.lu.se/record/37489932 URI
024	7	a https://doi.org/10.1038/ng.25712 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1264924572 URI
040		a (SwePub)lud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Iles, Mark M.4 aut
245	1 0	a A variant in FTO shows association with melanoma risk not due to BMI
264		c 2013-03-03
264	1	b Springer Science and Business Media LLC,c 2013
520		a We report the results of an association study of melanoma that is based on the genome-wide imputation of the genotypes of 1,353 cases and 3,566 controls of European origin conducted by the GenoMEL consortium. This revealed an association between several SNPs in intron 8 of the FTO gene, including rs16953002, which replicated using 12,313 cases and 55,667 controls of European ancestry from Europe, the USA and Australia (combined P = 3.6 x 10(-12), per-allele odds ratio for allele A = 1.16). In addition to identifying a new melanomasusceptibility locus, this is to our knowledge the first study to identify and replicate an association with SNPs in FTO not related to body mass index (BMI). These SNPs are not in intron 1 (the BMI-related region) and exhibit no association with BMI. This suggests FTO's function may be broader than the existing paradigm that FTO variants influence multiple traits only through their associations with BMI and obesity.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
700	1	a Law, Matthew H.4 aut
700	1	a Stacey, Simon N.4 aut
700	1	a Han, Jiali4 aut
700	1	a Fang, Shenying4 aut
700	1	a Pfeiffer, Ruth4 aut
700	1	a Harland, Mark4 aut
700	1	a MacGregor, Stuart4 aut
700	1	a Taylor, John C.4 aut
700	1	a Aben, Katja K.4 aut
700	1	a Akslen, Lars A.4 aut
700	1	a Avril, Marie-Francoise4 aut
700	1	a Azizi, Esther4 aut
700	1	a Bakker, Bert4 aut
700	1	a Benediktsdottir, Kristrun R.4 aut
700	1	a Bergman, Wilma4 aut
700	1	a Scarra, Giovanna Bianchi4 aut
700	1	a Brown, Kevin M.4 aut
700	1	a Calista, Donato4 aut
700	1	a Chaudru, Valerie4 aut
700	1	a Fargnoli, Maria Concetta4 aut
700	1	a Cust, Anne E.4 aut
700	1	a Demenais, Florence4 aut
700	1	a Waal, Anne C. de4 aut
700	1	a Debniak, Tadeusz4 aut
700	1	a Elder, David E.4 aut
700	1	a Friedman, Eitan4 aut
700	1	a Galan, Pilar4 aut
700	1	a Ghiorzo, Paola4 aut
700	1	a Gillanders, Elizabeth M.4 aut
700	1	a Goldstein, Alisa M.4 aut
700	1	a Gruis, Nelleke A.4 aut
700	1	a Hansson, Johanu Karolinska Institutet4 aut
700	1	a Helsing, Per4 aut
700	1	a Hocevar, Marko4 aut
700	1	a Hoiom, Veronicau Karolinska Institutet4 aut
700	1	a Hopper, John L.4 aut
700	1	a Ingvar, Christianu Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)kir-cin
700	1	a Janssen, Marjolein4 aut
700	1	a Jenkins, Mark A.4 aut
700	1	a Kanetsky, Peter A.4 aut
700	1	a Kiemeney, Lambertus A.4 aut
700	1	a Lang, Julie4 aut
700	1	a Lathrop, G. Mark4 aut
700	1	a Leachman, Sancy4 aut
700	1	a Lee, Jeffrey E.4 aut
700	1	a Lubinski, Jan4 aut
700	1	a Mackie, Rona M.4 aut
700	1	a Mann, Graham J.4 aut
700	1	a Martin, Nicholas G.4 aut
700	1	a Mayordomo, Jose I.4 aut
700	1	a Molven, Anders4 aut
700	1	a Mulder, Suzanne4 aut
700	1	a Nagore, Eduardo4 aut
700	1	a Novakovic, Srdjan4 aut
700	1	a Okamoto, Ichiro4 aut
700	1	a Olafsson, Jon H.4 aut
700	1	a Olsson, Håkanu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-hol
700	1	a Pehamberger, Hubert4 aut
700	1	a Peris, Ketty4 aut
700	1	a Grasa, Maria Pilar4 aut
700	1	a Planelles, Dolores4 aut
700	1	a Puig, Susana4 aut
700	1	a Puig-Butille, Joan Anton4 aut
700	1	a Randerson-Moor, Juliette4 aut
700	1	a Requena, Celia4 aut
700	1	a Rivoltini, Licia4 aut
700	1	a Rodolfo, Monica4 aut
700	1	a Santinami, Mario4 aut
700	1	a Sigurgeirsson, Bardur4 aut
700	1	a Snowden, Helen4 aut
700	1	a Song, Fengju4 aut
700	1	a Sulem, Patrick4 aut
700	1	a Thorisdottir, Kristin4 aut
700	1	a Tuominen, Raineru Karolinska Institutet4 aut
700	1	a Van Belle, Patricia4 aut
700	1	a van der Stoep, Nienke4 aut
700	1	a van Rossum, Michelle M.4 aut
700	1	a Wei, Qingyi4 aut
700	1	a Wendt, Judith4 aut
700	1	a Zelenika, Diana4 aut
700	1	a Zhang, Mingfeng4 aut
700	1	a Landi, Maria Teresa4 aut
700	1	a Thorleifsson, Gudrnar4 aut
700	1	a Bishop, D. Timothy4 aut
700	1	a Amos, Christopher I.4 aut
700	1	a Hayward, Nicholas K.4 aut
700	1	a Stefansson, Kari4 aut
700	1	a Bishop, Julia A. Newton4 aut
700	1	a Barrett, Jennifer H.4 aut
710	2	a Karolinska Institutetb Kirurgi, Lund4 org
773	0	t Nature Geneticsd : Springer Science and Business Media LLCg 45:4, s. 428-432q 45:4<428-432x 1546-1718x 1061-4036
856	4	u http://dx.doi.org/10.1038/ng.2571y FULLTEXT
856	4	u https://europepmc.org/articles/pmc3640814?pdf=render
856	4 8	u https://lup.lub.lu.se/record/3748993
856	4 8	u https://doi.org/10.1038/ng.2571
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:126492457

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Av författaren/redakt...: Iles, Mark M.; Law, Matthew H.; Stacey, Simon N.; Han, Jiali; Fang, Shenying; Pfeiffer, Ruth; visa fler...; Harland, Mark; MacGregor, Stuar ...; Taylor, John C.; Aben, Katja K.; Akslen, Lars A.; Avril, Marie-Fra ...; Azizi, Esther; Bakker, Bert; Benediktsdottir, ...; Bergman, Wilma; Scarra, Giovanna ...; Brown, Kevin M.; Calista, Donato; Chaudru, Valerie; Fargnoli, Maria ...; Cust, Anne E.; Demenais, Floren ...; Waal, Anne C. de; Debniak, Tadeusz; Elder, David E.; Friedman, Eitan; Galan, Pilar; Ghiorzo, Paola; Gillanders, Eliz ...; Goldstein, Alisa ...; Gruis, Nelleke A ...; Hansson, Johan; Helsing, Per; Hocevar, Marko; Hoiom, Veronica; Hopper, John L.; Ingvar, Christia ...; Janssen, Marjole ...; Jenkins, Mark A.; Kanetsky, Peter ...; Kiemeney, Lamber ...; Lang, Julie; Lathrop, G. Mark; Leachman, Sancy; Lee, Jeffrey E.; Lubinski, Jan; Mackie, Rona M.; Mann, Graham J.; Martin, Nicholas ...; Mayordomo, Jose ...; Molven, Anders; Mulder, Suzanne; Nagore, Eduardo; Novakovic, Srdja ...; Okamoto, Ichiro; Olafsson, Jon H.; Olsson, Håkan; Pehamberger, Hub ...; Peris, Ketty; Grasa, Maria Pil ...; Planelles, Dolor ...; Puig, Susana; Puig-Butille, Jo ...; Randerson-Moor, ...; Requena, Celia; Rivoltini, Licia; Rodolfo, Monica; Santinami, Mario; Sigurgeirsson, B ...; Snowden, Helen; Song, Fengju; Sulem, Patrick; Thorisdottir, Kr ...; Tuominen, Rainer; Van Belle, Patri ...; van der Stoep, N ...; van Rossum, Mich ...; Wei, Qingyi; Wendt, Judith; Zelenika, Diana; Zhang, Mingfeng; Landi, Maria Ter ...; Thorleifsson, Gu ...; Bishop, D. Timot ...; Amos, Christophe ...; Hayward, Nichola ...; Stefansson, Kari; Bishop, Julia A. ...; Barrett, Jennife ...; visa färre...

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