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The Finnish Geriatr...
The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) : Study design and progress
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- Kivipelto, Miia (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),University of Eastern Finland, Finland; National Institute for Health and Welfare, Finland; Karolinska Institutet, Sweden
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- Solomon, Alina (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),University of Eastern Finland, Finland; Karolinska Institutet, Sweden
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Ahtiluoto, Satu (author)
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- Ngandu, Tiia (author)
- Karolinska Institutet
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Lehtisalo, Jenni (author)
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Antikainen, Riitta (author)
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- Bäckman, Lars (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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Hanninen, Tuomo (author)
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Jula, Antti (author)
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Laatikainen, Tiina (author)
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Lindström, Jaana (author)
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- Mangialasche, Francesca (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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Nissinen, Aulikki (author)
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Paajanen, Teemu (author)
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Pajala, Satu (author)
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Peltonen, Markku (author)
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Rauramaa, Rainer (author)
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- Stigsdotter-Neely, Anna (author)
- Umeå universitet,Institutionen för psykologi
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Strandberg, Timo (author)
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Tuomilehto, Jaakko (author)
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Soininen, Hilkka (author)
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(creator_code:org_t)
- 2013-01-18
- 2013
- English.
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In: Alzheimer's & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 9:6, s. 657-665
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
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- Background: Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a multi-center, randomized, controlled trial ongoing in Finland. Materials: Participants (1200 individuals at risk of cognitive decline) are recruited from previous population-based non-intervention studies. Inclusion criteria are CAIDE Dementia Risk Score >= 6 and cognitive performance at the mean level or slightly lower than expected for age (but not substantial impairment) assessed with the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological battery. The 2-year multidomain intervention consists of: nutritional guidance; exercise; cognitive training and social activity; and management of metabolic and vascular risk factors. Persons in the control group receive regular health advice. The primary outcome is cognitive performance as measured by the modified Neuropsychological Test Battery, Stroop test, and Trail Making Test. Main secondary outcomes are: dementia (after extended follow-up); disability; depressive symptoms; vascular risk factors and outcomes; quality of life; utilization of health resources; and neuroimaging measures. Results: Screening began in September 2009 and was completed in December 2011. All 1200 persons are enrolled and the intervention is ongoing as planned. Baseline clinical characteristics indicate that several vascular risk factors and unhealthy lifestyle related factors are present, creating a window of opportunity for prevention. The intervention will be completed during 2014. Conclusions: The FINGER is at the forefront of international collaborative efforts to solve the clinical and public health problems of early identification of individuals at increased risk of late-life cognitive impairment, and of developing intervention strategies to prevent or delay the onset of cognitive impairment and dementia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Cognitive impairment
- Dementia
- Alzheimer's disease
- Lifestyle
- Intervention
- Randomized trial
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kivipelto, Miia
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Solomon, Alina
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Ahtiluoto, Satu
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Ngandu, Tiia
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Lehtisalo, Jenni
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Antikainen, Riit ...
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show more...
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Bäckman, Lars
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Hanninen, Tuomo
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Jula, Antti
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Laatikainen, Tii ...
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Lindström, Jaana
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Mangialasche, Fr ...
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Nissinen, Aulikk ...
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Paajanen, Teemu
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Pajala, Satu
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Peltonen, Markku
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Rauramaa, Rainer
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Stigsdotter-Neel ...
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Strandberg, Timo
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Tuomilehto, Jaak ...
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Soininen, Hilkka
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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- Articles in the publication
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Alzheimer's & De ...
- By the university
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Stockholm University
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Umeå University
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Karolinska Institutet