Sökning: (WFRF:(Lohman Kurt)) pers:(Ridker Paul M.) > (2015-2019) > Novel genetic assoc...
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001 | oai:DiVA.org:umu-150780 | |
003 | SwePub | |
008 | 180831s2018 | |||||||||||000 ||eng| | |
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009 | oai:lup.lub.lu.se:f6c9eb6b-d0a6-4524-be1b-172813823da1 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1507802 URI |
024 | 7 | a https://doi.org/10.1371/journal.pone.01981662 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1386407922 URI |
024 | 7 | a https://lup.lub.lu.se/record/f6c9eb6b-d0a6-4524-be1b-172813823da12 URI |
040 | a (SwePub)umud (SwePub)kid (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
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100 | 1 | a Feitosa, Mary F.u Washington University in St. Louis4 aut |
245 | 1 0 | a Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries |
264 | c 2018-06-18 | |
264 | 1 | b Public library science,c 2018 |
338 | a electronic2 rdacarrier | |
520 | a Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci and contribute to the understanding of alcohol-related BP regulation. We conducted a large two-stage investigation incorporating joint testing of main genetic effects and single nucleotide variant (SNV)-alcohol consumption interactions. In Stage 1, genome-wide discovery meta-analyses in approximate to 131 K individuals across several ancestry groups yielded 3,514 SNVs (245 loci) with suggestive evidence of association (P <1.0 x 10(-5)). In Stage 2, these SNVs were tested for independent external replication in individuals across multiple ancestries. We identified and replicated (at Bonferroni correction threshold) five novel BP loci (380 SNVs in 21 genes) and 49 previously reported BP loci (2,159 SNVs in 109 genes) in European ancestry, and in multi-ancestry meta-analyses (P < 5.0 x 10(-8)). For African ancestry samples, we detected 18 potentially novel BP loci (P< 5.0 x 10(-8)) in Stage 1 that warrant further replication. Additionally, correlated meta-analysis identified eight novel BP loci (11 genes). Several genes in these loci (e.g., PINX1, GATA4, BLK, FTO and GABBR2 have been previously reported to be associated with alcohol consumption. These findings provide insights into the role of alcohol consumption in the genetic architecture of hypertension. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng |
700 | 1 | a Kraja, Aldi T.u Washington University in St. Louis4 aut |
700 | 1 | a Chasman, Daniel I.u Harvard Medical School,Brigham and Women's Hospital / Harvard Medical School4 aut |
700 | 1 | a Sung, Yun J.u Washington University in St. Louis4 aut |
700 | 1 | a Winkler, Thomas W.u University of Regensburg4 aut |
700 | 1 | a Ntalla, Ioannau Queen Mary University4 aut |
700 | 1 | a Guo, Xiuqingu University of California, Los Angeles4 aut |
700 | 1 | a Franceschini, Norau University of North Carolina4 aut |
700 | 1 | a Cheng, Ching-Yuu Duke–NUS Medical School,National University of Singapore,Singapore Eye Research Institute4 aut |
700 | 1 | a Sim, Xuelingu National University Health System4 aut |
700 | 1 | a Vojinovic, Dinau Erasmus University Medical Center4 aut |
700 | 1 | a Marten, Jonathanu University of Edinburgh4 aut |
700 | 1 | a Musani, Solomon K.u University of Mississippi Medical Center4 aut |
700 | 1 | a Li, Changweiu University of Georgia4 aut |
700 | 1 | a Bentley, Amy R.u National Human Genome Research Institute4 aut |
700 | 1 | a Brown, Michael R.u University of Texas4 aut |
700 | 1 | a Schwander, Karenu Washington University in St. Louis4 aut |
700 | 1 | a Richard, Melissa A.u University of Texas4 aut |
700 | 1 | a Noordam, Raymondu Leiden University Medical Centre4 aut |
700 | 1 | a Aschard, Huguesu Harvard University,Pasteur Institute4 aut |
700 | 1 | a Bartz, Traci M.u University of Washington4 aut |
700 | 1 | a Bielak, Lawrence F.u University of Michigan4 aut |
700 | 1 | a Dorajoo, Rajkumaru A*Star, Genome Institute of Singapore (GIS)4 aut |
700 | 1 | a Fisher, Virginiau Boston University4 aut |
700 | 1 | a Hartwig, Fernando P.u Federal University of Pelotas,University of Bristol4 aut |
700 | 1 | a Horimoto, Andrea R. V. R.u University of São Paulo4 aut |
700 | 1 | a Lohman, Kurt K.u Wake Forest University4 aut |
700 | 1 | a Manning, Alisa K.u Harvard Medical School,Massachusetts General Hospital4 aut |
700 | 1 | a Rankinen, Tuomou Pennington Biomedical Research Center4 aut |
700 | 1 | a Smith, Albert V.u University of Iceland,Icelandic Heart Association4 aut |
700 | 1 | a Tajuddin, Salman M.u National Institute on Aging, United States4 aut |
700 | 1 | a Wojczynski, Mary K.u Washington University in St. Louis4 aut |
700 | 1 | a Alver, Marisu University of Tartu4 aut |
700 | 1 | a Boissel, Mathildeu University of Lille4 aut |
700 | 1 | a Cai, Qiuyinu Vanderbilt University4 aut |
700 | 1 | a Campbell, Archieu University of Edinburgh4 aut |
700 | 1 | a Chai, Jin Fangu National University Health System4 aut |
700 | 1 | a Chen, Xuu Karolinska Institute,Karolinska Institutet4 aut |
700 | 1 | a Divers, Jasminu Wake Forest University4 aut |
700 | 1 | a Gao, Chuanu Wake Forest University,Washington University in St. Louis4 aut |
700 | 1 | a Goel, Anuju University of Oxford4 aut |
700 | 1 | a Hagemeijer, Yanicku University Medical Center Groningen4 aut |
700 | 1 | a Harris, Sarah E.u University of Edinburgh4 aut |
700 | 1 | a He, Meianu Huazhong University of Science and Technology4 aut |
700 | 1 | a Hsu, Fang-Chiu Wake Forest University4 aut |
700 | 1 | a Jackson, Anne U.u University of Michigan4 aut |
700 | 1 | a Kahonen, Mikau Tampere University Hospital,University of Tampere4 aut |
700 | 1 | a Kasturiratne, Anuradhaniu University of Kelaniya4 aut |
700 | 1 | a Komulainen, Pirjou Karolinska Institutet4 aut |
700 | 1 | a Kuhnel, Brigitte4 aut |
700 | 1 | a Laguzzi, Federicau Karolinska Institutet4 aut |
700 | 1 | a Luan, Jian'an4 aut |
700 | 1 | a Matoba, Nana4 aut |
700 | 1 | a Nolte, Ilja M.4 aut |
700 | 1 | a Padmanabhan, Sandosh4 aut |
700 | 1 | a Riaz, Muhammad4 aut |
700 | 1 | a Rueedi, Rico4 aut |
700 | 1 | a Robino, Antonietta4 aut |
700 | 1 | a Said, M. Abdullah4 aut |
700 | 1 | a Scott, Robert A.4 aut |
700 | 1 | a Sofer, Tamar4 aut |
700 | 1 | a Stancakova, Alena4 aut |
700 | 1 | a Takeuchi, Fumihiko4 aut |
700 | 1 | a Tayo, Bamidele O.4 aut |
700 | 1 | a van der Most, Peter J.4 aut |
700 | 1 | a Varga, Tibor V.u Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,Genetic and Molecular Epidemiology,Skåne University Hospital4 aut0 (Swepub:lu)med-tv_ |
700 | 1 | a Vitart, Veronique4 aut |
700 | 1 | a Wang, Yajuan4 aut |
700 | 1 | a Ware, Erin B.4 aut |
700 | 1 | a Warren, Helen R.4 aut |
700 | 1 | a Weiss, Stefan4 aut |
700 | 1 | a Franks, Paul W.u Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,Genetic and Molecular Epidemiology,Harvard University4 aut0 (Swepub:lu)med-plf |
700 | 1 | a Yanek, Lisa R.4 aut |
700 | 1 | a Zhang, Weihua4 aut |
700 | 1 | a Zhao, Jing Hua4 aut |
700 | 1 | a Afaq, Saima4 aut |
700 | 1 | a Amin, Najaf4 aut |
700 | 1 | a Amini, Marzyeh4 aut |
700 | 1 | a Arking, Dan E.4 aut |
700 | 1 | a Aung, Tin4 aut |
700 | 1 | a Boerwinkle, Eric4 aut |
700 | 1 | a Borecki, Ingrid4 aut |
700 | 1 | a Broeckel, Ulrich4 aut |
700 | 1 | a Brown, Morris4 aut |
700 | 1 | a Brumat, Marco4 aut |
700 | 1 | a Burke, Gregory L.4 aut |
700 | 1 | a Canouil, Mickael4 aut |
700 | 1 | a Chakravarti, Aravinda4 aut |
700 | 1 | a Charumathi, Sabanayagam4 aut |
700 | 1 | a Chen, Yii-Der Ida4 aut |
700 | 1 | a Connell, John M.4 aut |
700 | 1 | a Correa, Adolfo4 aut |
700 | 1 | a Fuentes, Lisa de las4 aut |
700 | 1 | a de Mutsert, Renee4 aut |
700 | 1 | a de Silva, H. Janaka4 aut |
700 | 1 | a Deng, Xuan4 aut |
700 | 1 | a Ding, Jingzhong4 aut |
700 | 1 | a Duan, Qing4 aut |
700 | 1 | a Eaton, Charles B.4 aut |
700 | 1 | a Ehret, Georg4 aut |
700 | 1 | a Eppinga, Ruben N.4 aut |
700 | 1 | a Evangelou, Evangelos4 aut |
700 | 1 | a Fau, Jessica D.4 aut |
700 | 1 | a Felix, Stephan B.4 aut |
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700 | 1 | a Forrester, Terrence4 aut |
700 | 1 | a Franco, Oscar H.4 aut |
700 | 1 | a Friedlander, Yechiel4 aut |
700 | 1 | a Gandin, Ilaria4 aut |
700 | 1 | a Gao, He4 aut |
700 | 1 | a Ghanbari, Mohsen4 aut |
700 | 1 | a Gigante, Brunau Karolinska Institutet4 aut |
700 | 1 | a Gu, C. Charles4 aut |
700 | 1 | a Gu, Dongfeng4 aut |
700 | 1 | a Hagenaars, Saskia P.4 aut |
700 | 1 | a Hallmans, Göran,d 1947-u Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001 |
700 | 1 | a Harris, Tamara B.4 aut |
700 | 1 | a He, Jiang4 aut |
700 | 1 | a Heikkinen, Sami4 aut |
700 | 1 | a Heng, Chew-Kiat4 aut |
700 | 1 | a Hirata, Makoto4 aut |
700 | 1 | a Howard, Barbara V.4 aut |
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700 | 1 | a Katsuya, Tomohiro4 aut |
700 | 1 | a Khor, Chiea Chuen4 aut |
700 | 1 | a Kilpelainen, Tuomas O.4 aut |
700 | 1 | a Koh, Woon-Puay4 aut |
700 | 1 | a Krieger, Jose E.4 aut |
700 | 1 | a Kritchevsky, Stephen B.4 aut |
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700 | 1 | a Kuusisto, Johanna4 aut |
700 | 1 | a Lakka, Timo A.4 aut |
700 | 1 | a Langefeld, Carl D.4 aut |
700 | 1 | a Langenberg, Claudia4 aut |
700 | 1 | a Launer, Lenore J.4 aut |
700 | 1 | a Lehne, Benjamin4 aut |
700 | 1 | a Lewis, Cora E.4 aut |
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700 | 1 | a Magi, Reedik4 aut |
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700 | 1 | a Metspalu, Andres4 aut |
700 | 1 | a Milaneschi, Yuri4 aut |
700 | 1 | a Milani, Lili4 aut |
700 | 1 | a Mohlke, Karen L.u Karolinska Institutet4 aut |
700 | 1 | a Momozawa, Yukihide4 aut |
700 | 1 | a Nalls, Mike A.4 aut |
700 | 1 | a Nelson, Christopher P.4 aut |
700 | 1 | a Sotoodehnia, NelsonNona4 aut |
700 | 1 | a Norris, Jill M.4 aut |
700 | 1 | a O'Connell, Jeff R.4 aut |
700 | 1 | a Palmer, Nicholette D.4 aut |
700 | 1 | a Perls, Thomas4 aut |
700 | 1 | a Pedersen, Nancy L.u Karolinska Institutet4 aut |
700 | 1 | a Peters, Annette4 aut |
700 | 1 | a Peyser, Patricia A.4 aut |
700 | 1 | a Poulter, Neil4 aut |
700 | 1 | a Raffel, Leslie J.4 aut |
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700 | 1 | a Scott, William R.4 aut |
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700 | 1 | a Williams, Christine4 aut |
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700 | 1 | a Franks, Paul W.u Umeå universitet,Avdelningen för medicin4 aut0 (Swepub:umu)pafr0003 |
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700 | 1 | a Samani, Nilesh J.4 aut |
700 | 1 | a Scott, James4 aut |
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700 | 1 | a Christensen, Kaare4 aut |
700 | 1 | a Evans, Michele K.4 aut |
700 | 1 | a Gudnason, Vilmundur4 aut |
700 | 1 | a Horta, Bernardo L.4 aut |
700 | 1 | a Kardia, Sharon L. R.4 aut |
700 | 1 | a Liu, Yongmei4 aut |
700 | 1 | a Pereira, Alexandre C.4 aut |
700 | 1 | a Psaty, Bruce M.4 aut |
700 | 1 | a Ridker, Paul M.4 aut |
700 | 1 | a van Dam, Rob M.4 aut |
700 | 1 | a Gauderman, W. James4 aut |
700 | 1 | a Zhu, Xiaofeng4 aut |
700 | 1 | a Mook-Kanamori, Dennis O.4 aut |
700 | 1 | a Fornage, Myriam4 aut |
700 | 1 | a Rotimi, Charles N.4 aut |
700 | 1 | a Cupples, L. Adrienne4 aut |
700 | 1 | a Kelly, Tanika N.4 aut |
700 | 1 | a Fox, Ervin R.4 aut |
700 | 1 | a Hayward, Caroline4 aut |
700 | 1 | a van Duijn, Cornelia M.4 aut |
700 | 1 | a Tai, E. Shyong4 aut |
700 | 1 | a Wong, Tien Yin4 aut |
700 | 1 | a Kooperberg, Charles4 aut |
700 | 1 | a Palmas, Walter4 aut |
700 | 1 | a Rice, Kennethu University of Washington4 aut |
700 | 1 | a Morrison, Alanna C.u University of Texas4 aut |
700 | 1 | a Elliott, Paulu Imperial College London4 aut |
700 | 1 | a Caulfield, Mark J.u Queen Mary University4 aut |
700 | 1 | a Munroe, Patricia B.u Queen Mary University4 aut |
700 | 1 | a Rao, Dabeeru C.4 aut |
700 | 1 | a Province, Michael A.u Washington University in St. Louis4 aut |
700 | 1 | a Levy, Danielu Framingham Heart Study,National Heart Lung and Blood Institute4 aut |
710 | 2 | a Washington University in St. Louisb Harvard Medical School4 org |
773 | 0 | t PLOS ONEd : Public library scienceg 13:6q 13:6x 1932-6203 |
856 | 4 | u https://doi.org/10.1371/journal.pone.0198166y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1244286/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0198166&type=printable |
856 | 4 | u http://dx.doi.org/10.1371/journal.pone.0198166x freey FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-150780 |
856 | 4 8 | u https://doi.org/10.1371/journal.pone.0198166 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:138640792 |
856 | 4 8 | u https://lup.lub.lu.se/record/f6c9eb6b-d0a6-4524-be1b-172813823da1 |
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