Sökning: (WFRF:(Lundberg Peter)) >
A uni fi ed framewo...
A uni fi ed framework for prediction of liver steatosis dynamics in response to different diet and drug interventions
-
- Simonsson, Christian (författare)
- Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Medicinsk strålningsfysik
-
- Nyman, Elin (författare)
- Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten
-
- Gennemark, Peter (författare)
- Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten,AstraZeneca, Sweden
-
visa fler...
-
- Gustafsson, Peter (författare)
- Linköpings universitet,Avdelningen för medicinsk teknik,Medie- och Informationsteknik,Tekniska fakulteten
-
- Hotz, Ingrid (författare)
- Linköpings universitet,Medie- och Informationsteknik,Tekniska fakulteten
-
- Ekstedt, Mattias (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Mag- tarmmedicinska kliniken
-
- Lundberg, Peter (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Medicinsk strålningsfysik
-
- Cedersund, Gunnar (författare)
- Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV
-
visa färre...
-
(creator_code:org_t)
- CHURCHILL LIVINGSTONE, 2024
- 2024
- Engelska.
-
Ingår i: Clinical Nutrition. - : CHURCHILL LIVINGSTONE. - 0261-5614 .- 1532-1983. ; 43:6, s. 1532-1543
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background & aims: Non-alcoholic fatty liver disease (NAFLD) is a common metabolic disorder, characterized by the accumulation of excess fat in the liver, and is a driving factor for various severe liver diseases. These multi -factorial and multi-timescale changes are observed in different clinical studies, but these studies have not been integrated into a uni fied framework. In this study, we aim to present such a uni fied framework in the form of a dynamic mathematical model. Methods: For model training and validation, we collected data for dietary or drug -induced interventions aimed at reducing or increasing liver fat. The model was formulated using ordinary differential equations (ODEs) and the mathematical analysis, model simulation, model formulation and the model parameter estimation were all performed in MATLAB. Results: Our mathematical model describes accumulation of fat in the liver and predicts changes in lipid fluxes induced by both dietary and drug interventions. The model is validated using data from a wide range of drug and dietary intervention studies and can predict both short-term (days) and long-term (weeks) changes in liver fat. Importantly, the model computes the contribution of each individual lipid flux to the total liver fat dynamics. Furthermore, the model can be combined with an established bodyweight model, to simulate even longer scenarios (years), also including the effects of insulin resistance and body weight. To help prepare for corresponding eHealth applications, we also present a way to visualize the simulated changes, using dynamically changing lipid droplets, seen in images of liver biopsies. Conclusion: In conclusion, we believe that the minimal model presented herein might be a useful tool for future applications, and to further integrate and understand data regarding changes in dietary and drug induced changes in ectopic TAG in the liver. With further development and validation, the minimal model could be used as a disease progression model for steatosis. (c) 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Nyckelord
- Mathematical modelling; NAFLD; Steatosis; Systems biology; Diets
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas