Search: (WFRF:(Mattiello Amalia)) srt2:(2010-2014) >
Leptin and soluble ...
Leptin and soluble leptin receptor in risk of colorectal cancer in the European prospective investigation into Cancer and nutrition cohort
-
Aleksandrova, Krasimira (author)
-
Boeing, Heiner (author)
-
Jenab, Mazda (author)
-
show more...
-
Bueno-de-Mesquita, H. Bas (author)
-
Jansen, Eugene (author)
-
van Duijnhoven, Franzel J. B. (author)
-
Rinaldi, Sabina (author)
-
Fedirko, Veronika (author)
-
Romieu, Isabelle (author)
-
Riboli, Elio (author)
-
Gunter, Marc J. (author)
-
Westphal, Sabine (author)
-
Overvad, Kim (author)
-
Tjonneland, Anne (author)
-
Halkjaer, Jytte (author)
-
Racine, Antoine (author)
-
Boutron-Ruault, Marie-Christine (author)
-
Clavel-Chapelon, Francoise (author)
-
Kaaks, Rudolf (author)
-
Lukanova, Annekatrin (author)
-
Trichopoulou, Antonia (author)
-
Lagiou, Pagona (author)
-
Trichopoulos, Dimitrios (author)
-
Mattiello, Amalia (author)
-
Pala, Valeria (author)
-
Palli, Domenico (author)
-
Tumino, Rosario (author)
-
Vineis, Paolo (author)
-
Buckland, Genevieve (author)
-
Sanchez, Maria-Jose (author)
-
Amiano, Pilar (author)
-
Maria Huerta, Jose (author)
-
Barricarte, Aurelio (author)
-
Menendez, Virginia (author)
-
Peeters, Petra H. (author)
-
- Söderberg, Stefan (author)
- Umeå universitet,Kardiologi
-
- Palmqvist, Richard (author)
- Umeå universitet,Patologi
-
Allen, Naomi E. (author)
-
Crowe, Francesca L. (author)
-
Khaw, Kay-Tee (author)
-
Wareham, Nickolas (author)
-
Pischon, Tobias (author)
-
show less...
-
(creator_code:org_t)
- Philadelphia, USA : American Association for Cancer Research, 2012
- 2012
- English.
-
In: Cancer Research. - Philadelphia, USA : American Association for Cancer Research. - 0008-5472 .- 1538-7445. ; 72:20, s. 5328-5337
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Leptin, a peptide hormone produced primarily by the adipocytes, is hypothesized to play a role in the pathogenesis of colorectal cancer (CRC). Soluble leptin receptor (sOB-R) may regulate leptin's physiologic functions; however its relation to CRC risk is unknown. This study explored the association of leptin and sOB-R with risk of CRC in a prospective nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 1,129 incident CRC cases (713 colon, 416 rectal) were matched within risk sets to 1,129 controls. Conditional logistic regression was used to calculate relative risks (RR) and 95% confidence intervals (CI). After multivariable adjustment including body mass index (BMI), waist circumference, and baseline leptin concentrations, sOB-R was strongly inversely associated with CRC (RR comparing the highest quintile vs. the lowest, 0.55; 95% CI, 0.40-0.76; P-trend = 0.0004) and colon cancer (RR, 0.42; 95% CI, 0.28-0.63, P-trend = 0.0001); whereas no association was seen for rectal cancer (RR adjusted for BMI and waist circumference, 0.83; 95% CI, 0.48-1.44, P-trend = 0.38). In contrast, leptin was not associated with risk of CRC (RR adjusted for BMI and waist circumference, 0.85; 95% CI, 0.56-1.29, P-trend = 0.23). Additional adjustments for circulating metabolic biomarkers did not attenuate these results. These novel findings suggest a strong inverse association between circulating sOB-R and CRC risk, independent of obesity measures, leptin concentrations, and other metabolic biomarkers. Further research is needed to confirm the potentially important role of sOB-R in CRC pathogenesis. Cancer Res; 72(20); 5328-37. (C) 2012 AACR.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Aleksandrova, Kr ...
-
Boeing, Heiner
-
Jenab, Mazda
-
Bueno-de-Mesquit ...
-
Jansen, Eugene
-
van Duijnhoven, ...
-
show more...
-
Rinaldi, Sabina
-
Fedirko, Veronik ...
-
Romieu, Isabelle
-
Riboli, Elio
-
Gunter, Marc J.
-
Westphal, Sabine
-
Overvad, Kim
-
Tjonneland, Anne
-
Halkjaer, Jytte
-
Racine, Antoine
-
Boutron-Ruault, ...
-
Clavel-Chapelon, ...
-
Kaaks, Rudolf
-
Lukanova, Anneka ...
-
Trichopoulou, An ...
-
Lagiou, Pagona
-
Trichopoulos, Di ...
-
Mattiello, Amali ...
-
Pala, Valeria
-
Palli, Domenico
-
Tumino, Rosario
-
Vineis, Paolo
-
Buckland, Genevi ...
-
Sanchez, Maria-J ...
-
Amiano, Pilar
-
Maria Huerta, Jo ...
-
Barricarte, Aure ...
-
Menendez, Virgin ...
-
Peeters, Petra H ...
-
Söderberg, Stefa ...
-
Palmqvist, Richa ...
-
Allen, Naomi E.
-
Crowe, Francesca ...
-
Khaw, Kay-Tee
-
Wareham, Nickola ...
-
Pischon, Tobias
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Cancer Research
- By the university
-
Umeå University