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Antiretroviral ther...
Antiretroviral therapy non-adherence among children living with HIV in Dire Dawa, Eastern Ethiopia : a case-control study
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- Mengesha, Melkamu Merid (författare)
- Arba Minch University
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- Embibel, Mulugeta (författare)
- Dire Dawa Regional Health Bureau
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- Gobena, Tesfaye (författare)
- Haramaya University
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- Tunje, Abayneh (författare)
- Lund University,Lunds universitet,Barns och familjers hälsa,Forskargrupper vid Lunds universitet,Child and Family Health,Lund University Research Groups,Arba Minch University
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- Jerene, Degu (författare)
- Royal Netherlands Tuberculosis Association (KNCV)
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- Hallström, Inger Kristensson (författare)
- Lund University,Lunds universitet,Barns och familjers hälsa,Forskargrupper vid Lunds universitet,Child and Family Health,Lund University Research Groups
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(creator_code:org_t)
- 2022-11-10
- 2022
- Engelska.
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Ingår i: BMC Pediatrics. - : Springer Science and Business Media LLC. - 1471-2431. ; 22:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: In 2018, nearly 90% of the global children living with human immunodeficiency virus (HIV) were in sub-Saharan Africa (SSA). Compared to the adult population, antiretroviral therapy (ART) coverage among children was limited. However, adherence remained a problem among children though they had limited access to ART. This study was conducted to identify the risk factors of non-adherence to ART among children aged 6 to 17 years. Methods:: This case-control study was conducted in 2020 using data obtained from clinical record reviews and self-reported data from 272 caregivers of HIV-infected children aged 6–17 years. Cases and controls represented children with poor versus children with good adherence to ART, respectively. Good adherence was defined based on a past 30-day physician adherence evaluation of taking ≥ 95% of the prescribed doses. Binary logistic regression was used to identify factors associated with non-adherence to ART. All statistical tests are defined as statistically significant at P-values < 0.05. Results:: Of the 272 children, for whom data were obtained, 78 were cases and 194 were controls; females accounted for 56.3%, 32% attended secondary school, and for 83.1%, the reporting caregivers were biological parents. Non-adherent children had higher odds of association with the following risk factors: a caregiver who is a current substance user (aOR = 2.87, 95% CI: 1.44, 5.71), using AZT-and ABC-based regimen compared to the TDF-regimen (AZT-based, aOR = 4.12, 95% CI: 1.43, 11.86; ABC-based, aOR = 5.58, 95% CI: 1.70, 18.30), and had an increase in viral load from baseline compared to those remained undetectable (remained at or decreased to < 1000, aOR = 4.87, 95% CI: 1.65, 14.33; remained at ≥ 1000, aOR = 9.30, 95% CI: 3.69, 23.46). In contrast, non-adherent children had 66% lower odds of being at early adolescent age compared to 6–9 years old (10–14 years, aOR = 0.34, 95% CI: 0.12, 0.99) and had 70% lower odds of being aware of their HIV status (aOR = 0.30, 95% CI: 0.13, 0.73). Conclusion:: Technical support to caregivers to build disclosure self-efficacy, identifying the appropriate regimen for children, counseling on viral load suppression on subsequent visits, and helping caregivers avoid or reduce substance use may help improve the problem of children’s non-adherence to ART.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- and viral load
- Children
- HIV status disclosure
- Non-adherence to ART
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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