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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004809naa a2200565 4500
001oai:DiVA.org:hh-51592
003SwePub
008230907s2023 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-515922 URI
0247 a https://doi.org/10.1038/s41423-023-01070-52 DOI
040 a (SwePub)hh
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Gu, Pengu Southern Medical University, Guangzhou, China4 aut
2451 0a A metabolite from commensal Candida albicans enhances the bactericidal activity of macrophages and protects against sepsis
264 1a London :b Nature Publishing Group,c 2023
338 a print2 rdacarrier
500 a Funding: The National Natural Science Foundation of China (32271230 and 32071124) to PC; the NIH Grant (P30DK120515) to BS; the National Natural Science Foundation of China (82270581) to YC; the National Key R&D Project of China (2018YFC0115301), the National Natural Science Foundation of China (81974070), the Shenzhen Science and Technology Program (JCYJ20210324131010027) and the Research Foundation of Shenzhen Hospital of Southern Medical University (PT2018GZR10) to WG.
520 a The gut microbiome is recognized as a key modulator of sepsis development. However, the contribution of the gut mycobiome to sepsis development is still not fully understood. Here, we demonstrated that the level of Candida albicans was markedly decreased in patients with bacterial sepsis, and the supernatant of Candida albicans culture significantly decreased the bacterial load and improved sepsis symptoms in both cecum ligation and puncture (CLP)-challenged mice and Escherichia coli-challenged pigs. Integrative metabolomics and the genetic engineering of fungi revealed that Candida albicans-derived phenylpyruvate (PPA) enhanced the bactericidal activity of macrophages and reduced organ damage during sepsis. Mechanistically, PPA directly binds to sirtuin 2 (SIRT2) and increases reactive oxygen species (ROS) production for eventual bacterial clearance. Importantly, PPA enhanced the bacterial clearance capacity of macrophages in sepsis patients and was inversely correlated with the severity of sepsis in patients. Our findings highlight the crucial contribution of commensal fungi to bacterial disease modulation and expand our understanding of the host-mycobiome interaction during sepsis development. © 2023, The Author(s), under exclusive licence to CSI and USTC.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Dermatologi och venereologi0 (SwePub)302042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dermatology and Venereal Diseases0 (SwePub)302042 hsv//eng
653 a Bacterial clearance
653 a Candida albicans
653 a Macrophage
653 a Phenylpyruvate
653 a Sepsis
7001 a Liu, Ruofanu Southern Medical University, Guangzhou, China4 aut
7001 a Yang, Qinu Southern Medical University, Guangzhou, China4 aut
7001 a Xie, Liu Southern Medical University, Guangzhou, China4 aut
7001 a Wei, Rongjuanu Southern Medical University, Guangzhou, China4 aut
7001 a Li, Jiaxinu Southern Medical University, Guangzhou, China4 aut
7001 a Mei, Fengyiu Southern Medical University, Guangzhou, China4 aut
7001 a Chen, Taou Southern Medical University, Guangzhou, China4 aut
7001 a Zeng, Zhenhuau Southern Medical University, Guangzhou, China4 aut
7001 a He, Yanu Southern Medical University, Guangzhou, China4 aut
7001 a Zhou, Hongweiu Southern Medical University, Guangzhou, China4 aut
7001 a Peng, Hongjuanu Southern Medical University, Guangzhou, China4 aut
7001 a Nandakumar, Kutty Selva,d 1965-u Högskolan i Halmstad,Akademin för företagande, innovation och hållbarhet4 aut0 (Swepub:hh)kutnam
7001 a Chu, Huikuanu Tongji Medical College, Wuhan, China4 aut
7001 a Jiang, Yongu Southern Medical University, Guangzhou, China4 aut
7001 a Gong, Weiu Southern Medical University, Guangzhou, China4 aut
7001 a Chen, Yeu Southern Medical University, Guangzhou, China4 aut
7001 a Schnabl, Berndu Department of Medicine, San Diego, United States4 aut
7001 a Chen, Pengu Southern Medical University, Guangzhou, China4 aut
7102 a Southern Medical University, Guangzhou, Chinab Akademin för företagande, innovation och hållbarhet4 org
7730 t Cellular & Molecular Immunologyd London : Nature Publishing Groupg 20:10, s. 1156-1170q 20:10<1156-1170x 1672-7681x 2042-0226
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-51592
8564 8u https://doi.org/10.1038/s41423-023-01070-5

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