Adiposity, mediating biomarkers and risk of colon cancer in the European prospective investigation into cancer and nutrition study

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Sökning: (WFRF:(Romieu Isabelle)) pers:(Clavel Chapelon Francoise) > Adiposity, mediatin...

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Fältnamn	Indikatorer	Metadata
000		05151naa a2200901 4500
001		oai:DiVA.org:umu-80827
003		SwePub
008		130926s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-808272 URI
024	7	a https://doi.org/10.1002/ijc.283682 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Aleksandrova, Krasimira4 aut
245	1 0	a Adiposity, mediating biomarkers and risk of colon cancer in the European prospective investigation into cancer and nutrition study
264		c 2013-11-20
264	1	b Wiley-Blackwell,c 2014
338		a print2 rdacarrier
500		a First published online 5 August 2013.
520		a Adiposity is a risk factor for colon cancer, but underlying mechanisms are not well understood. We evaluated the extent to which 11 biomarkers with inflammatory and metabolic actions mediate the association of adiposity measures, waist circumference (WC) and body mass index (BMI), with colon cancer in men and women. We analyzed data from a prospective nested case-control study among 662 incident colon cancer cases matched within risk sets to 662 controls. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. The percent effect change and corresponding CIs were estimated after adjusting for biomarkers shown to be associated with colon cancer risk. After multivariable adjustment, WC was associated with colon cancer risk in men (top vs. bottom tertile RR 1.68, 95% CI 1.06-2.65; ptrend = 0.02) and in women (RR 1.67, 95% CI 1.09-2.56; ptrend = 0.03). BMI was associated with risk only in men. The association of WC with colon cancer was accounted mostly for by three biomarkers, high-density lipoprotein cholesterol, non-high-molecular-weight adiponectin and soluble leptin receptor, which in combination explained 46% (95% CI 37-57%) of the association in men and 50% (95% CI 40-65%) of the association in women. Similar results were observed for the associations with BMI in men. These data suggest that alterations in levels of these metabolic biomarkers may represent a primary mechanism of action in the relation of adiposity with colon cancer. Further studies are warranted to determine whether altering their concentrations may reduce colon cancer risk.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653		a colon cancer
653		a adiposity
653		a waist circumference
653		a body mass index
653		a mediating biomarkers
700	1	a Drogan, Dagmar4 aut
700	1	a Boeing, Heiner4 aut
700	1	a Jenab, Mazda4 aut
700	1	a Bas Bueno-de-Mesquita, H4 aut
700	1	a Jansen, Eugene4 aut
700	1	a van Duijnhoven, Fränzel J B4 aut
700	1	a Rinaldi, Sabina4 aut
700	1	a Fedirko, Veronika4 aut
700	1	a Romieu, Isabelle4 aut
700	1	a Kaaks, Rudolf4 aut
700	1	a Riboli, Elio4 aut
700	1	a Gunter, Marc J4 aut
700	1	a Romaguera, Dora4 aut
700	1	a Westhpal, Sabine4 aut
700	1	a Overvad, Kim4 aut
700	1	a Tjønneland, Anne4 aut
700	1	a Halkjaer, Jytte4 aut
700	1	a Boutron-Ruault, Marie-Christine4 aut
700	1	a Clavel-Chapelon, Françoise4 aut
700	1	a Lukanova, Annekatrin4 aut
700	1	a Trichopoulou, Antonia4 aut
700	1	a Trichopoulos, Dimitrios4 aut
700	1	a Vidalis, Pavlos4 aut
700	1	a Panico, Salvatore4 aut
700	1	a Agnoli, Claudia4 aut
700	1	a Palli, Domenico4 aut
700	1	a Tumino, Rosario4 aut
700	1	a Vineis, Paolo4 aut
700	1	a Buckland, Genevieve4 aut
700	1	a Sánchez-Cruz, José-Juan4 aut
700	1	a Dorronsoro, Miren4 aut
700	1	a Díaz, María José Tormo4 aut
700	1	a Barricarte, Aurelio4 aut
700	1	a Ramon Quiros, J4 aut
700	1	a Peeters, Petra H4 aut
700	1	a May, Anne M4 aut
700	1	a Hallmans, Göranu Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001
700	1	a Palmqvist, Richardu Umeå universitet,Patologi4 aut0 (Swepub:umu)ripa0001
700	1	a Crowe, Francesca L4 aut
700	1	a Khaw, Kay-Tee4 aut
700	1	a Wareham, Nickolas4 aut
700	1	a Pischon, Tobias4 aut
710	2	a Umeå universitetb Näringsforskning4 org
773	0	t International Journal of Cancerd : Wiley-Blackwellg 134:3, s. 612-621q 134:3<612-621x 0020-7136x 1097-0215
856	4	u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.28368
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-80827
856	4 8	u https://doi.org/10.1002/ijc.28368

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Av författaren/redakt...: Aleksandrova, Kr ...; Drogan, Dagmar; Boeing, Heiner; Jenab, Mazda; Bas Bueno-de-Mes ...; Jansen, Eugene; visa fler...; van Duijnhoven, ...; Rinaldi, Sabina; Fedirko, Veronik ...; Romieu, Isabelle; Kaaks, Rudolf; Riboli, Elio; Gunter, Marc J; Romaguera, Dora; Westhpal, Sabine; Overvad, Kim; Tjønneland, Anne; Halkjaer, Jytte; Boutron-Ruault, ...; Clavel-Chapelon, ...; Lukanova, Anneka ...; Trichopoulou, An ...; Trichopoulos, Di ...; Vidalis, Pavlos; Panico, Salvator ...; Agnoli, Claudia; Palli, Domenico; Tumino, Rosario; Vineis, Paolo; Buckland, Genevi ...; Sánchez-Cruz, Jo ...; Dorronsoro, Mire ...; Díaz, María José ...; Barricarte, Aure ...; Ramon Quiros, J; Peeters, Petra H; May, Anne M; Hallmans, Göran; Palmqvist, Richa ...; Crowe, Francesca ...; Khaw, Kay-Tee; Wareham, Nickola ...; Pischon, Tobias; visa färre...

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