(WFRF:(Scheele C.)) pers:(Pedersen B K)
Sökning: (WFRF:(Scheele C.)) pers:(Pedersen B K) > Altered DNA Methyla...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06640naa a2200721 4500 | |
| 001 | oai:gup.ub.gu.se/204289 | |
| 003 | SwePub | |
| 008 | 240910s2014 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:38cbfe41-5064-4c25-96e0-219816d5c09d | |
| 009 | oai:prod.swepub.kib.ki.se:129685800 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2042892 URI |
| 024 | 7 | a https://doi.org/10.2337/db13-14592 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/44555782 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1296858002 URI |
| 040 | a (SwePub)gud (SwePub)lud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Nilsson, Emma Au Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Diabetes - epigenetik,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Diabetes - Epigenetics4 aut0 (Swepub:lu)endo-eca |
| 245 | 1 0 | a Altered DNA Methylation and Differential Expression of Genes Influencing Metabolism and Inflammation in Adipose Tissue From Subjects With Type 2 Diabetes |
| 264 | c 2014-08-16 | |
| 264 | 1 | b American Diabetes Association,c 2014 |
| 520 | a Genetics, epigenetics, and environment may together affect the susceptibility for type 2 diabetes (T2D). Our aim was to dissect molecular mechanisms underlying T2D using genome-wide expression and DNA methylation data in adipose tissue from monozygotic twin pairs discordant for T2D and independent case-control cohorts. In adipose tissue from diabetic twins, we found decreased expression of genes involved in oxidative phosphorylation; carbohydrate, amino acid, and lipid metabolism; and increased expression of genes involved in inflammation and glycan degradation. The most differentially expressed genes included ELOVL6, GYS2, FADS1, SPP1 (OPN), CCL18, and IL1RN. We replicated these results in adipose tissue from an independent case-control cohort. Several candidate genes for obesity and T2D (e.g., IRS1 and VEGFA) were differentially expressed in discordant twins. We found a heritable contribution to the genome-wide DNA methylation variability in twins. Differences in methylation between monozygotic twin pairs discordant for T2D were subsequently modest. However, 15,627 sites, representing 7,046 genes including PPARG, KCNQ1, TCF7L2, and IRS1, showed differential DNA methylation in adipose tissue from unrelated subjects with T2D compared with control subjects. A total of 1,410 of these sites also showed differential DNA methylation in the twins discordant for T2D. For the differentially methylated sites, the heritability estimate was 0.28. We also identified copy number variants (CNVs) in monozygotic twin pairs discordant for T2D. Taken together, subjects with T2D exhibit multiple transcriptional and epigenetic changes in adipose tissue relevant to the development of the disease. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 653 | a HUMAN PANCREATIC-ISLETS | |
| 653 | a INSULIN-RESISTANCE | |
| 653 | a MONOZYGOTIC TWINS | |
| 653 | a SKELETAL-MUSCLE | |
| 653 | a PROFILES | |
| 653 | a OBESITY | |
| 653 | a OSTEOPONTIN | |
| 653 | a DENSITY | |
| 653 | a IMPACT | |
| 653 | a FAT | |
| 653 | a Endocrinology & Metabolism | |
| 700 | 1 | a Jansson, Per-Anders,d 1961u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xjansp |
| 700 | 1 | a Perfilyev, Alexanderu Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups4 aut0 (Swepub:lu)med-apy |
| 700 | 1 | a Volkov, Petru Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Diabetes - epigenetik,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Diabetes - Epigenetics4 aut0 (Swepub:lu)med-pvo |
| 700 | 1 | a Pedersen, M.4 aut |
| 700 | 1 | a Svensson, Maria Ku Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xsmara |
| 700 | 1 | a Poulsen, P.4 aut |
| 700 | 1 | a Ribel-Madsen, R.4 aut |
| 700 | 1 | a Pedersen, N. L.u Karolinska Institutet4 aut |
| 700 | 1 | a Almgren, Peteru Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-pal |
| 700 | 1 | a Fadista, Joaou Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)med-jft |
| 700 | 1 | a Rönn, Tinau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Diabetes - epigenetik,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Diabetes - Epigenetics4 aut0 (Swepub:lu)med-tar |
| 700 | 1 | a Pedersen, B. K.4 aut |
| 700 | 1 | a Scheele, C.4 aut |
| 700 | 1 | a Vaag, Allanu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)med-ava |
| 700 | 1 | a Ling, Charlotteu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Diabetes - epigenetik,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Diabetes - Epigenetics4 aut0 (Swepub:lu)endo-cl0 |
| 710 | 2 | a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Diabetesd : American Diabetes Associationg 63:9, s. 2962-2976q 63:9<2962-2976x 0012-1797x 1939-327X |
| 856 | 4 | u https://diabetes.diabetesjournals.org/content/diabetes/63/9/2962.full.pdf |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/24812430?dopt=Abstracty FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.2337/db13-1459y FULLTEXT |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/204289 |
| 856 | 4 8 | u https://doi.org/10.2337/db13-1459 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/4455578 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:129685800 |
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