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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005320naa a2200565 4500
001oai:DiVA.org:umu-132625
003SwePub
008170814s2017 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1326252 URI
0247 a https://doi.org/10.1186/s12889-017-4117-y2 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Gaziano, Thomas A.4 aut
2451 0a Cardiometabolic risk in a population of older adults with multiple co-morbidities in rural south africa :b the HAALSI (Health and Aging in Africa: longitudinal studies of INDEPTH communities) study
264 c 2017-02-17
264 1b Springer Science and Business Media LLC,c 2017
338 a electronic2 rdacarrier
520 a Background: A consequence of the widespread uptake of anti-retroviral therapy (ART) is that the older South African population will experience an increase in life expectancy, increasing their risk for cardiometabolic diseases (CMD), and its risk factors. The long-term interactions between HIV infection, treatment, and CMD remain to be elucidated in the African population. The HAALSI cohort was established to investigate the impact of these interactions on CMD morbidity and mortality among middle-aged and older adults. Methods: We recruited randomly selected adults aged 40 or older residing in the rural Agincourt sub-district in Mpumalanga Province. In-person interviews were conducted to collect baseline household and socioeconomic data, self-reported health, anthropometric measures, blood pressure, high-sensitivity C-reactive protein (hsCRP), HbA1c, HIV-status, and point-of-care glucose and lipid levels. Results: Five thousand fifty nine persons (46.4% male) were enrolled with a mean age of 61.7 +/- 13.06 years. Waist-to- hip ratio was high for men and women (0.92 +/- 0.08 vs. 0.89 +/- 0.08), with 70% of women and 44% of men being overweight or obese. Blood pressure was similar for men and women with a combined hypertension prevalence of 58.4% and statistically significant increases were observed with increasing age. High total cholesterol prevalence in women was twice that observed for men (8.5 vs. 4.1%). The prevalence of self-reported CMD conditions was higher among women, except for myocardial infarction, and women had a statistically significantly higher prevalence of angina (10.82 vs. 6.97%) using Rose Criteria. The HIV- persons were significantly more likely to have hypertension, diabetes, or be overweight or obese than HIV+ persons. Approximately 56% of the cohort had at least 2 measured or self-reported clinical co-morbidities, with HIV+ persons having a consistently lower prevalence of co-morbidities compared to those without HIV. Absolute 10-year risk cardiovascular risk scores ranged from 7.7-9.7% for women and from 12.5-15.3% for men, depending on the risk score equations used. Conclusions: This cohort has high CMD risk based on both traditional risk factors and novel markers like hsCRP. Longitudinal follow-up of the cohort will allow us to determine the long-term impact of increased lifespan in a population with both high HIV infection and CMD risk.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653 a Cardiovascular
653 a Cardiometabolic
653 a HIV
653 a Aging
653 a Antiretrovirals
653 a Hypertension
653 a Diabetes
7001 a Abrahams-Gessel, Shafika4 aut
7001 a Gomez-Olive, F. Xavier4 aut
7001 a Wade, Alisha4 aut
7001 a Crowther, Nigel J.4 aut
7001 a Alam, Sartaj4 aut
7001 a Manne-Goehler, Jennifer4 aut
7001 a Kabudula, Chodziwadziwa W.4 aut
7001 a Wagner, Ryanu Umeå universitet,Epidemiologi och global hälsa,University of the Witwatersrand, Johannesburg, South Africa ; INDEPTH Network, Accra, Ghana ; Africa Wits-INDEPTH Genomic Studies of Cardiovascular Disease, University of the Witwatersrand4 aut0 (Swepub:umu)rywa0001
7001 a Rohr, Julia4 aut
7001 a Montana, Livia4 aut
7001 a Kahn, Kathleenu Umeå universitet,Epidemiologi och global hälsa,University of the Witwatersrand, Johannesburg, South Africa ; INDEPTH Network, Accra, Ghana ; Africa Wits-INDEPTH Genomic Studies of Cardiovascular Disease, University of the Witwatersrand4 aut0 (Swepub:umu)kaka0045
7001 a Baernighausen, Till W.4 aut
7001 a Berkman, Lisa F.4 aut
7001 a Tollman, Stephen4 aut
7102 a Umeå universitetb Epidemiologi och global hälsa4 org
7730 t BMC Public Healthd : Springer Science and Business Media LLCg 17q 17x 1471-2458
8564 u https://umu.diva-portal.org/smash/get/diva2:1131272/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://bmcpublichealth.biomedcentral.com/track/pdf/10.1186/s12889-017-4117-y
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-132625
8564 8u https://doi.org/10.1186/s12889-017-4117-y

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