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Anthropometric Meas...
Anthropometric Measures, Body Mass Index, and Pancreatic Cancer A Pooled Analysis From the Pancreatic Cancer Cohort Consortium (PanScan)
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Arslan, Alan A. (author)
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Helzlsouer, Kathy J. (author)
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Kooperberg, Charles (author)
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show more...
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Shu, Xiao-Ou (author)
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Steplowski, Emily (author)
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Bueno-de-Mesquita, H. Bas (author)
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Fuchs, Charles S. (author)
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Gross, Myron D. (author)
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Jacobs, Eric J. (author)
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LaCroix, Andrea Z. (author)
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Petersen, Gloria M. (author)
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Stolzenberg-Solomon, Rachael Z. (author)
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Zheng, Wei (author)
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Albanes, Demetrius (author)
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Amundadottir, Laufey (author)
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Bamlet, William R. (author)
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Barricarte, Aurelio (author)
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Bingham, Sheila A. (author)
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Boeing, Heiner (author)
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Boutron-Ruault, Marie-Christine (author)
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Buring, Julie E. (author)
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Chanock, Stephen J. (author)
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Clipp, Sandra (author)
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Gaziano, J. Michael (author)
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Giovannucci, Edward L. (author)
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Hankinson, Susan E. (author)
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Hartge, Patricia (author)
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Hoover, Robert N. (author)
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Hunter, David J. (author)
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Hutchinson, Amy (author)
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Jacobs, Kevin B. (author)
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Kraft, Peter (author)
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Lynch, Shannon M. (author)
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- Manjer, Jonas (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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Manson, JoAnn E. (author)
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McTiernan, Anne (author)
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McWilliams, Robert R. (author)
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Mendelsohn, Julie B. (author)
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Michaud, Dominique S. (author)
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Palli, Domenico (author)
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Rohan, Thomas E. (author)
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Slimani, Nadia (author)
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Thomas, Gilles (author)
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Tjonneland, Anne (author)
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Tobias, Geoffrey S. (author)
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Trichopoulos, Ditnitrios (author)
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Virtamo, Jarmo (author)
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Wolpin, Brian M. (author)
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Yu, Kai (author)
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Zeleniuch-Jacquotte, Anne (author)
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Patel, Alpa V. (author)
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(creator_code:org_t)
- 2010
- 2010
- English.
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In: Archives of Internal Medicine. - 0003-9926. ; 170:9, s. 791-802
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http://archinte.ama-...
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https://lup.lub.lu.s...
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Abstract
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- Background: Obesity has been proposed as a risk factor for pancreatic cancer. Methods: Pooled data were analyzed from the National Cancer Institute Pancreatic Cancer Cohort Consortium (PanScan) to study the association, between prediagnostic anthropometric measures and risk of pancreatic cancer. PanScan applied a nested case-control study design and included 2170 cases and 2209 control subjects. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression for cohort-specific quartiles of body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]), weight, height, waist circumference, and waist to hip ratio as well as conventional BMI categories (underweight, <18.5; normal weight, 18.5-24.9; overweight, 25.0-29.9; obese, 30.0-34.9; and severely obese, >= 35.0). Models were adjusted for potential confounders. Results: In all of the participants, a positive association between increasing BMI and risk of pancreatic cancer was observed (adjusted OR for the highest vs lowest BMI guartile, 1.33; 95% Cl, 1.12-1.58; P-trend<.001). In men, the adjusted OR for pancreatic cancer for the highest vs lowest quartile of BMI was 1.33 (95% Cl, 1.04-1.69; P-trend<.03), and in women it was 1.34 (95% Cl, 1.05-1.70; P-trend=.01). Increased waist to hip ratio was associated with increased risk of pancreatic cancer in women (adjusted OR for the highest vs lowest quartile, 1.87; 95% Cl, 1.31-2.69; P-trend=.003) but less so in men. Conclusions: These findings provide strong support for a positive association between BMI and pancreatic cancer risk. In addition, centralized fat distribution may increase pancreatic cancer risk, especially in women. Arch Intern Med. 2010;170(9):791 -802
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Arslan, Alan A.
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Helzlsouer, Kath ...
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Kooperberg, Char ...
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Shu, Xiao-Ou
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Steplowski, Emil ...
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Bueno-de-Mesquit ...
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show more...
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Fuchs, Charles S ...
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Gross, Myron D.
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Jacobs, Eric J.
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LaCroix, Andrea ...
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Petersen, Gloria ...
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Stolzenberg-Solo ...
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Zheng, Wei
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Albanes, Demetri ...
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Amundadottir, La ...
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Bamlet, William ...
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Barricarte, Aure ...
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Bingham, Sheila ...
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Boeing, Heiner
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Boutron-Ruault, ...
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Buring, Julie E.
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Chanock, Stephen ...
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Clipp, Sandra
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Gaziano, J. Mich ...
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Giovannucci, Edw ...
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Hankinson, Susan ...
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Hartge, Patricia
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Hoover, Robert N ...
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Hunter, David J.
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Hutchinson, Amy
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Jacobs, Kevin B.
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Kraft, Peter
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Lynch, Shannon M ...
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Manjer, Jonas
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Manson, JoAnn E.
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McTiernan, Anne
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McWilliams, Robe ...
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Mendelsohn, Juli ...
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Michaud, Dominiq ...
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Palli, Domenico
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Rohan, Thomas E.
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Slimani, Nadia
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Thomas, Gilles
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Tjonneland, Anne
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Tobias, Geoffrey ...
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Trichopoulos, Di ...
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Virtamo, Jarmo
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Wolpin, Brian M.
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Yu, Kai
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Zeleniuch-Jacquo ...
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Patel, Alpa V.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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Lund University