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Association of NFKB...
Association of NFKBIA polymorphism with colorectal cancer risk and prognosis in Swedish and Chinese populations
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- Gao, Jingfang, 1966- (author)
- Linköpings universitet,Hälsouniversitetet,Onkologi
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- Pfeifer, Daniella, 1981- (author)
- Linköpings universitet,Hälsouniversitetet,Onkologi
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He, Lu-Jun (author)
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Qiao, Fang (author)
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Zhang, Zhiyong (author)
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- Arbman, Gunnar, 1949- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Avdelningen för kirurgi,Kirurgiska kliniken i Östergötland med verksamhet i Linköping, Norrköping och Motala
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Wang, Zhen-Lei (author)
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Jia, Cun-Rong (author)
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- Carstensen, John, 1953- (author)
- Linköpings universitet,Filosofiska fakulteten,Tema hälsa och samhälle
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- Sun, Xiao-Feng, 1959- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Onkologiska kliniken US
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(creator_code:org_t)
- 2009-07-08
- 2007
- English.
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In: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 0036-5521 .- 1502-7708. ; 42:3, s. 345-350
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Objective. The inhibitory proteins, IκBs, regulate the activity of nuclear factor kappa-beta (NF-κB), which is implicated in tumorigenesis by regulating expression of a variety of genes involved in cellular transformation, proliferation, invasion, angiogenesis and metastasis. Variants in the genes encoding IκBs may be involved in cancer development through the activation of NF-κB. The objective of this study was to investigate the susceptibility of an A to G variation (rs696) in the 3′ UTR of NFKBIA (encoding IκBα) to colorectal cancer (CRC) and the association of this polymorphism with clinicopathologic variables in CRC patients. Material and methods. A case-control study was carried out on a Swedish (155 CRCs, 438 controls) and a Chinese population (199 CRCs, 577 controls). The genotype of NFKBIA was determined by PCR-restriction fragment length polymorphism. Results. The frequency of the AG genotype was increased in the Chinese patients ≥50 years of age compared with the Chinese controls (odds ratio (OR) = 3.06, 95% confidence interval (CI) = 1.55-6.02, p=0.001), even when adjusted for age (OR = 3.20, 95% CI = 1.61-6.38, p=0.001). The GG genotype of NFKBIA was related to a poorer survival rate in the Swedish patients, independent of gender, age, tumour location, Dukes' stage and differentiation (hazard ratio = 3.10, 95% Cl = 1.28-7.60, p=0.01). Conclusions. Chinese individuals ≥50 years of age carrying the AG genotype of NFKBIA may be at an increased risk of developing CRC, and the GG genotype of NFKBIA may be considered as a prognostic factor for Swedish CRC patients. © 2007 Taylor & Francis.
Keyword
- MEDICINE
- MEDICIN
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- ref (subject category)
- art (subject category)
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Gao, Jingfang, 1 ...
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Pfeifer, Daniell ...
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He, Lu-Jun
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Qiao, Fang
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Zhang, Zhiyong
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Arbman, Gunnar, ...
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show more...
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Wang, Zhen-Lei
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Jia, Cun-Rong
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Carstensen, John ...
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Sun, Xiao-Feng, ...
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Scandinavian Jou ...
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Linköping University