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Search: (WFRF:(Sun Xiao Feng 1959 )) > (2005-2009) > Association of NFKB...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003679naa a2200397 4500
001oai:DiVA.org:liu-40004
003SwePub
008091010s2007 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-400042 URI
0247 a https://doi.org/10.1080/003655206008808562 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Gao, Jingfang,d 1966-u Linköpings universitet,Hälsouniversitetet,Onkologi4 aut0 (Swepub:liu)jinga59
2451 0a Association of NFKBIA polymorphism with colorectal cancer risk and prognosis in Swedish and Chinese populations
264 c 2009-07-08
264 1b Informa UK Limited,c 2007
338 a print2 rdacarrier
520 a Objective. The inhibitory proteins, IκBs, regulate the activity of nuclear factor kappa-beta (NF-κB), which is implicated in tumorigenesis by regulating expression of a variety of genes involved in cellular transformation, proliferation, invasion, angiogenesis and metastasis. Variants in the genes encoding IκBs may be involved in cancer development through the activation of NF-κB. The objective of this study was to investigate the susceptibility of an A to G variation (rs696) in the 3′ UTR of NFKBIA (encoding IκBα) to colorectal cancer (CRC) and the association of this polymorphism with clinicopathologic variables in CRC patients. Material and methods. A case-control study was carried out on a Swedish (155 CRCs, 438 controls) and a Chinese population (199 CRCs, 577 controls). The genotype of NFKBIA was determined by PCR-restriction fragment length polymorphism. Results. The frequency of the AG genotype was increased in the Chinese patients ≥50 years of age compared with the Chinese controls (odds ratio (OR) = 3.06, 95% confidence interval (CI) = 1.55-6.02, p=0.001), even when adjusted for age (OR = 3.20, 95% CI = 1.61-6.38, p=0.001). The GG genotype of NFKBIA was related to a poorer survival rate in the Swedish patients, independent of gender, age, tumour location, Dukes' stage and differentiation (hazard ratio = 3.10, 95% Cl = 1.28-7.60, p=0.01). Conclusions. Chinese individuals ≥50 years of age carrying the AG genotype of NFKBIA may be at an increased risk of developing CRC, and the GG genotype of NFKBIA may be considered as a prognostic factor for Swedish CRC patients. © 2007 Taylor & Francis.
653 a MEDICINE
653 a MEDICIN
7001 a Pfeifer, Daniella,d 1981-u Linköpings universitet,Hälsouniversitetet,Onkologi4 aut0 (Swepub:liu)danpf07
7001 a He, Lu-Jun4 aut
7001 a Qiao, Fang4 aut
7001 a Zhang, Zhiyong4 aut
7001 a Arbman, Gunnar,d 1949-u Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Avdelningen för kirurgi,Kirurgiska kliniken i Östergötland med verksamhet i Linköping, Norrköping och Motala4 aut0 (Swepub:liu)gunar63
7001 a Wang, Zhen-Lei4 aut
7001 a Jia, Cun-Rong4 aut
7001 a Carstensen, John,d 1953-u Linköpings universitet,Filosofiska fakulteten,Tema hälsa och samhälle4 aut0 (Swepub:liu)johca98
7001 a Sun, Xiao-Feng,d 1959-u Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Onkologiska kliniken US4 aut0 (Swepub:liu)xiasu45
7102 a Linköpings universitetb Hälsouniversitetet4 org
7730 t Scandinavian Journal of Gastroenterologyd : Informa UK Limitedg 42:3, s. 345-350q 42:3<345-350x 0036-5521x 1502-7708
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-40004
8564 8u https://doi.org/10.1080/00365520600880856

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